anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Antikörper

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Zusätzlich bieten wir Ihnen MAD2L1 Proteine (8) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MAD2L1 4085 Q13257
MAD2L1 56150 Q9Z1B5
MAD2L1 297176  
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Top anti-MAD2L1 Antikörper auf antikoerper-online.de

Showing 10 out of 147 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP Detection of human MAD2 by Western Blot and Immunoprecipitation. Samples: NETN whole cell lysate (50 ug for WB, 600 ug for IP) from HeLa cells. Antibodies: ABIN151995 used at 1 ug/ml for WB (A) and at 0.7 ug/mg lysate for IP (B). MAD2 was also immunoprecipitated using rabbit anti-MAD2 antibody ABIN151996 at 0.7 ug/mg lysate. Immunoprecipitated MAD2 was blotted using ABIN151996 at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 1 minute (A and B). Immunohistochemistry-Paraffin: MAD2L1 Antibody [ABIN151995] - Section of human lung carcinoma. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Maus Unkonjugiert ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (48.29 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MAD2L1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.62
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB IHC-P Image MAD2L1 antibody [C2C3], C-term detects MAD2L1 protein at cytoplasm and nucleus in human A549 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded human A549 xenograft. MAD2L1 antibody [C2C3], C-term , diluted at 1:250. WB Image Sample (30μg whole cell lysate) A:Hep G2 , B:MOLT4 , C:Raji , 12% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert WB Anti- Mad2L1 Picoband antibody, Western blotting All lanes: Anti Mad2L1  at 0.5ug/ml Lane 1: 293T Whole Cell Lysate at 40ug Lane 2: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 23KD Observed bind size: 23KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: MAD2L1 Antibody [NBP1-31311] - Paraffin-embedded DLD-1 xenograft, using antibody at 1:500 dilution. Western Blot: MAD2L1 Antibody [NBP1-31311] - A:Hep G2 B:MOLT4 C:Raji 12% SDS PAGE NBP1-31311 diluted at 1:1000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Maus Unkonjugiert IHC (p), IP, WB IImmunohistochemistry of normal testis (formalin fixed) after antigen retreival, stained with Anti-Mad2L1 (clone 17D10)). Primary spermatocytes show staining of both the cytoplasm and nucleus. Picture kindly supplied by M.d.Espen Burum-Auensen from Rikshospitalet, Norway 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
$455.57
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Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$619.30
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB Western blot analysis of Hela whole cell lysates, using MAD2L1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276825 staining  A549 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details

Am meisten referenzierte anti-MAD2L1 Antikörper

  1. Human Polyclonal MAD2L1 Primary Antibody für ICC, IF - ABIN151995 : Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. in Molecular biology of the cell 2007 (PubMed)
    Show all 13 Pubmed References

  2. Human Monoclonal MAD2L1 Primary Antibody für IHC (p), IP - ABIN108556 : Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. in Journal of clinical pathology 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal MAD2L1 Primary Antibody für IHC (p), IP - ABIN108555 : Gysin, Paquette, McMahon: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. in Molecular cancer research : MCR 2012 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal MAD2L1 Primary Antibody für ELISA, WB - ABIN561710 : Yeh, Yeh, Chen, Juang: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. in The Journal of biological chemistry 2012 (PubMed)

  5. Human Polyclonal MAD2L1 Primary Antibody für WB - ABIN2801908 : Gemma, Hosoya, Seike, Uematsu, Kurimoto, Hibino, Yoshimura, Shibuya, Kudoh, Emi: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. in Lung cancer (Amsterdam, Netherlands) 2001 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal MAD2L1 Primary Antibody für ICC, IF - ABIN441319 : Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. in Cancer science 2013 (PubMed)

  7. Human Polyclonal MAD2L1 Primary Antibody für ELISA, WB - ABIN268644 : Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. in Science (New York, N.Y.) 1996 (PubMed)

Weitere Antikörper gegen MAD2L1 Interaktionspartner

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaktionspartner

  1. we demonstrate that the CDC20 (zeige CDC20 Antikörper)-MAD2 complex could also be formed independently of the SAC (zeige ADCY10 Antikörper). Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20 (zeige CDC20 Antikörper)-MAD2 complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1 (zeige CCNB1 Antikörper), which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.

  2. MAD2-p31 (zeige ATP6V1E1 Antikörper)(comet) axis may serve as a potential therapeutic target for glioma.

  3. These results identify an unexpected dependency on TRIP13 (zeige TRIP13 Antikörper) in cells overexpressing Mad2.

  4. this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma

  5. MiR (zeige MLXIP Antikörper)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.

  6. Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.

  7. TRAP1 (zeige TRAP1 Antikörper) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (zeige TRAP1 Antikörper)/TBP7 (zeige PSMC4 Antikörper) quality control of CDK1 (zeige CDK1 Antikörper) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  8. Thes authors show that p31 (zeige ATP6V1E1 Antikörper)(comet) binding to the TRIP13 (zeige TRIP13 Antikörper) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (zeige TRIP13 Antikörper) "pore loops", which then unfold MAD2 in the presence of ATP.

  9. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (zeige BUB3 Antikörper) complex assembly

  10. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (zeige AURKB Antikörper).

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) Interaktionspartner

  1. immunofluorescence staining for mitotic arrest deficient 2-like 1 and the protein kinase (zeige CDK7 Antikörper) TTK, components of the spindle assembly checkpoint (SAC (zeige ADCY10 Antikörper)), suggested that this delay possibly involved SAC (zeige ADCY10 Antikörper) activation.

  2. Mad2 (zeige MXI1 Antikörper)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

  3. reduced MAD2 (zeige MXI1 Antikörper) levels attenuate the apoptotic response to mis (zeige AMH Antikörper)-segregating sex chromosomes and allow the formation of aneuploid sperm.

  4. p31comet-induced cell death is mediated by interactions with Mad2 (zeige MXI1 Antikörper)

  5. study shows that Mad2 (zeige MXI1 Antikörper) is a novel substrate for CCP6 (zeige AGBL4 Antikörper) in megakaryocytes; Mad2 (zeige MXI1 Antikörper) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  6. Exacerbating chromosome missegregation in CENP-E (zeige CENPE Antikörper)+/- mice by reducing levels of another mitotic checkpoint component (zeige BUB3 Antikörper), Mad2 (zeige MXI1 Antikörper), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  7. Mad2 (zeige MXI1 Antikörper) is also repressed by p53 (zeige TP53 Antikörper) and its upregulation is required for chromosome instability in a p53 (zeige TP53 Antikörper) mutant tumor model

  8. Data show that Mad2 (zeige MXI1 Antikörper) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (zeige APEX1 Antikörper) inhibitor in vitro.

  9. Pcid2 (zeige PCID2 Antikörper) is essential for B cell survival through the regulation of MAD2 (zeige MXI1 Antikörper) expression during B cell differentiation

  10. tumours that experience transient Mad2 (zeige MXI1 Antikörper) overexpression and consequent chromosome instability recur at markedly elevated rates

MAD2L1 Antigen-Profil

Protein Überblick

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Genbezeichner und Symbole assoziert mit MAD2L1

  • mitotic arrest deficient 2 like 1 (MAD2L1) Antikörper
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1) Antikörper
  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1) Antikörper
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1) Antikörper
  • mitotic arrest deficient 2 like 1 (mad2l1) Antikörper
  • mitotic arrest deficient 2 like 1 (Mad2l1) Antikörper
  • mitotic arrest deficient 2 like 1 S homeolog (mad2l1.S) Antikörper
  • AA673185 Antikörper
  • cb408 Antikörper
  • HSMAD2 Antikörper
  • mad2 Antikörper
  • MAD2L1 Antikörper
  • XMad2 Antikörper
  • zgc:112133 Antikörper

Bezeichner auf Proteinebene für MAD2L1

MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , mitotic arrest deficient, yeast, homolog-like 1 , mitotic spindle assembly checkpoint protein MAD2A , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like 1 , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 , MAD2 mitotic arrest deficient-like 1 (yeast)

GENE ID SPEZIES
4085 Homo sapiens
56150 Mus musculus
337870 Bos taurus
422675 Gallus gallus
461661 Pan troglodytes
476070 Canis lupus familiaris
550434 Danio rerio
708574 Macaca mulatta
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
297176 Rattus norvegicus
380433 Xenopus laevis
100731050 Cavia porcellus
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