Lysine (K)-Specific Demethylase 5B Proteine (KDM5B)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Zusätzlich bieten wir Ihnen KDM5B Antikörper (133) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KDM5B 10765 Q9UGL1
KDM5B 75605 Q80Y84
Ratte KDM5B KDM5B 304809  
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Top KDM5B Proteine auf

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Insect cells (Sf9) Human DYKDDDDK Tag JARID1B / KDM5B activity assay. Recombinant JARID1B / KDM5B activity measured using a demethylation assay. MALDI-TOF was used for detection. Recombinant JARID1B / KDM5B enzymatic assay. Demethylase activity of JARID1B / KDM5B was measured with an enzymatic assay. MALDI-TOF was used for detection. Catalytic rate: 20 turnovers/enzyme/hour. 20 μg Anmelden zum Anzeigen 1 bis 2 Tage

KDM5B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Lysine (K)-Specific Demethylase 5B (KDM5B) Interaktionspartnern

Human Lysine (K)-Specific Demethylase 5B (KDM5B) Interaktionspartner

  1. both KDM5A (zeige KDM5A Proteine) and KDM5B are involved in the lengthening of DICER1 (zeige DICER1 Proteine)

  2. HBx activates the histone demethylase (zeige MBD2 Proteine) KDM5B and induces hepatic progenitor cell-like features in hepatocellular carcinoma

  3. JARID1B directly bound to PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling inhibitor SHIP1 (zeige INPP5D Proteine) gene promoter and decreased SHIP1 (zeige INPP5D Proteine) gene expression.

  4. We established the function of JARID1B in mediating the cancer stem cell potential of G0-like cells and our results expand understanding of its context-specific roles in malignant and normal stem cell homeostasis

  5. KDM5B is up-regulated in esophageal squamous cell carcinoma cells.MiR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression.

  6. Study identified USP15 (zeige USP15 Proteine) as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 (zeige FOXP1 Proteine) and KDM5B).

  7. research suggests that miR424-5p may act as a novel anti-oncogene (zeige RAB1A Proteine) in cervical cancer by blocking cell growth through targeting KDM5B-Notch (zeige NOTCH1 Proteine) pathway

  8. JARID1B is involved in the pathogenesis of glioma.

  9. PLU-1 was overexpressed in colorectal cancer tissue compared with healthy colon. PLU-1 expression positively correlated with colorectal cancer progression.

  10. Hsa-miR-448 disrupting KDM5B-MALAT1 signalling axis and associated activities in TNBC cells, projects it as a putative therapeutic factor for selective eradication of TNBC cells.

Mouse (Murine) Lysine (K)-Specific Demethylase 5B (KDM5B) Interaktionspartner

  1. KDM5B, which demethylates H3K4me3, plays an integral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternative splicing events in embryonic stem cells.

  2. data suggest Kdm5b negatively regulates neurogenesis and represses reelin (zeige RELN Proteine) in neural stem cells from the adult subventricular zone.

  3. These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.

  4. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  5. Deletion of Jarid1b compromises hematopoietic stem cell (HSC (zeige FUT1 Proteine)) self-renewal capacity; Jarid1b is a positive regulator of HSC (zeige FUT1 Proteine) potential.

  6. Mechanistically, JARID1B was required for GATA3 (zeige GATA3 Proteine) recruitment to the Foxa1 (zeige FOXA1 Proteine) promoter to activate Foxa1 (zeige FOXA1 Proteine) expression.

  7. KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.

  8. these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC (zeige FUT1 Proteine)) activity and Jhdmlf as a positive regulator of HSC (zeige FUT1 Proteine) activity.

  9. Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.

  10. results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation

Cow (Bovine) Lysine (K)-Specific Demethylase 5B (KDM5B) Interaktionspartner

  1. Histone demethylases KDM3A (zeige KDM3A Proteine), KDM4A (zeige KDM4A Proteine), and KDM4C (zeige KDM4C Proteine) were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

KDM5B Protein Überblick

Protein Überblick

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).

Genbezeichner und Symbole assoziert mit KDM5B

  • lysine (K)-specific demethylase 5Ba (kdm5ba)
  • lysine (K)-specific demethylase 5Bb (kdm5bb)
  • lysine demethylase 5B (KDM5B)
  • lysine (K)-specific demethylase 5B (Kdm5b)
  • lysine (K)-specific demethylase 5B (KDM5B)
  • lysine demethylase 5B (Kdm5b)
  • 2010009J12Rik Protein
  • 2210016I17Rik Protein
  • AW556288 Protein
  • cb264 Protein
  • CT31 Protein
  • D1Ertd202e Protein
  • id:ibd5050 Protein
  • Jarid1b Protein
  • jarid1ba Protein
  • jarid1bb Protein
  • mKIAA4034 Protein
  • PLU-1 Protein
  • Plu1 Protein
  • PUT1 Protein
  • Rb-Bp2 Protein
  • RBBP2H1A Protein
  • RGD1565602 Protein
  • wu:fc44h11 Protein
  • wu:fd15c05 Protein
  • zgc:85741 Protein

Bezeichner auf Proteinebene für KDM5B

jumonji, AT rich interactive domain 1B (Rbp2 like) , jumonji, AT rich interactive domain 1Ba (Rbp2 like) , histone demethylase JARID1B-B , jumonji/ARID domain-containing protein 1B-B , lysine-specific demethylase 5B-B , putative DNA/chromatin binding motif , lysine (K)-specific demethylase 5B , Jumonji, AT rich interactive domain 1B (RBP2-like) , jumonji, AT rich interactive domain 1B , lysine-specific demethylase 5B-like , RBP2-H1 , cancer/testis antigen 31 , histone demethylase JARID1B , jumonji/ARID domain-containing protein 1B , lysine-specific demethylase 5B , retinoblastoma-binding protein 2 homolog 1 , retinoblastoma-binding protein 2, homolog 1A , putative DNA/chromatin binding motif 1

327168 Danio rerio
415256 Danio rerio
457630 Pan troglodytes
100011885 Monodelphis domestica
100064707 Equus caballus
100077577 Ornithorhynchus anatinus
100356218 Oryctolagus cuniculus
100483283 Ailuropoda melanoleuca
10765 Homo sapiens
75605 Mus musculus
421168 Gallus gallus
479999 Canis lupus familiaris
100625438 Sus scrofa
540633 Bos taurus
304809 Rattus norvegicus
100723111 Cavia porcellus
Ausgewählte Anbieter für KDM5B Proteine (KDM5B)
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