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LOR encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Zusätzlich bieten wir Ihnen Loricrin Antikörper (19) und Loricrin Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Authors report a multi-generation family with prominent ichthyosis and palmoplantar involvement due to a novel mutation in loricrin.
Letter: Knockdown of either filaggrin (zeige FLG ELISA Kits) or loricrin increases the productions of interleukin (IL)-1alpha, IL-8 (zeige IL8 ELISA Kits), IL-18 (zeige IL18 ELISA Kits) and granulocyte macrophage colony-stimulating factor (zeige CSF2 ELISA Kits) in stratified human keratinocytes.
Studies on human keratinocytes recognized that loricrin expression was inversely related to the expression of the cyclin-dependent kinase (zeige CDK1 ELISA Kits) inhibitor p21 (zeige CDKN1A ELISA Kits)
two novel heterozygous frameshift mutations in exon 2 - c.646_647insGCAGCAGGTC, p.Gln216Argfs*123 and c.798_799dupT, p.Gly267Trpfs*69 in loricrin keratoderma patients
Results describe a novel frameshift mutation leading to loricrin keratoderma presenting with colloidion membrane
We found no mutations of Loricrin in two Progressive symmetrical erythrokeratoderma families.
We describe a young man who was a collodion baby and had the typical presentation of Loricrin keratoderma. Direct DNA sequencing identified a heterozygous mutation in the loricrin gene with a single G insertion, 730insG, present in (a) the patient
There were no mutations found in the LOR gene and the true pathogenesis of progressive symmetrical erythrokeratodermia remains unknown.
identified mRNA transcripts from three genes CDSN (zeige CDSN ELISA Kits), LOR and KRT9 (zeige KRT9 ELISA Kits), showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification
VEGF (zeige VEGFA ELISA Kits) release and the subsequent activation of VEGF receptor 2 link loricrin gene mutations to rapid cell proliferation in a cellular model of loricrin keratoderma.
the late cornified envelope 1 proteins are regulated by NRF2 (zeige NFE2L2 ELISA Kits) and are compensatory components for loricrin as determined by their localization within the loricrin knockout cell envelope via immunoelectron microscopy
Oct-6 (zeige POU3F1 ELISA Kits) and Oct-11 (zeige POU2F3 ELISA Kits) contribute to the regulation of loricrin gene transcription via interaction with AP-1 (zeige JUN ELISA Kits) factors and Sp1 (zeige SP1 ELISA Kits)/Sp3 (zeige SP3 ELISA Kits).
In the absence of loricrin, S. aureus nasal colonisation was significantly impaired.
The decreased expression of epidermal growth factor receptor (EGFR (zeige EGFR ELISA Kits)), E-cadherin (zeige CDH1 ELISA Kits), occludin (zeige OCLN ELISA Kits), and SIRT1 (zeige SIRT1 ELISA Kits) in the skin of Flg(ft (zeige FLG ELISA Kits)) mice, compared with those in C57BL/6J mice, is reported.
YY1 (zeige YY1 ELISA Kits) contributes to specific loricrin gene expression in differentiated keratinocytes by suppression of its transcription in undifferentiated keratinocytes.
nectin-1 (zeige PVRL1 ELISA Kits) plays a key role in the expression of loricrin in the epidermis
Skin biopsies from STAT6 (zeige STAT6 ELISA Kits) transgenic mice were deficient in the expression and production of loricrin and involucrin (zeige IVL ELISA Kits).
These results indicate AASS knockdown decreases the lysine requirement of the cell via a reduction of lysine catabolism through the saccharopine pathway.
Mice receiving the high-protein diet had greater AASS mRNA compared to mice fed the adequate protein diet.
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
, alpha-aminoadipic semialdehyde synthase, mitochondrial
, lysine oxoglutarate reductase
, saccharopine dehydrogenase