anti-Limbic System-Associated Membrane Protein (LSAMP) Antikörper

Human Limbic System-Associated Membrane Protein (LSAMP) Interaktionspartner

1. We detected African-specific SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for ulcerative colitis.

2. A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men

3. The results showed significant allelic and haplotypic associations between LSAMP gene and schizophrenia.

4. The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10.

5. This study presents the first evidence of a possible role of LSAMP gene in mood and anxiety disorders in humans.

6. proteomic assessments of membrane microdomains in prefrontal cortex and validation in two brain series, strongly implicates LAMP, STXBP1 and BASP1 in schizophreina and supports the view of a neuritic and synaptic dysfunction in the neuropathology

7. Single nucleotide polymorphisms of LSAMP is associated with the pathogenesis of coronary artery disease.

8. LSAMP might play a role in pathoaetiology of suicidal behaviour but further studies are needed to understand its exact contribution

9. results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas

10. Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.

Mouse (Murine) Limbic System-Associated Membrane Protein (LSAMP) Interaktionspartner

1. Phenotyping neurons derived from the hippocampi of Lsamp(-/-), Ntm(-/-) and Lsamp(-/-)Ntm(-/-) mice was performed in parallel with behavioral testing. Lsamp appears to be an enhancer of neurite outgrowth as premature neuritogenesis in Ntm(-/-) neurons is apparent only in the presence of Lsamp. Lsamp appeared to be a positive regulator of apoptosis in the presence of Ntm.

2. Limbic system-associated membrane protein is involved in emotional and social operating systems by complex regulation of two alternative promoters.

3. Lsamp(-/-) mice are a promising model to study the neurobiological mechanisms of deviant social behaviour and adaptation impairment observed in many psychiatric disorders.

4. Lsamp-deficient mice were less sensitive to isolation stress than their wild-type littermates.

5. results suggest that LAMP protein is not crucial for the general development of anatomical brain structures, but is needed for specific neural circuits that regulate anxiety-related and social behaviour.

6. lsamp knockout mice have a deficit in spatial memory acquisition and poorly sustained CA1 long-term potentiation.

7. genomic features of the Lsamp gene indicate an intricate mechanism of gene expression regulation that may be relevant in the context of human neuropsychiatric and neurological disorders, where LAMP expression may be altered

8. Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments.