Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6 Proteine (LGR6)

Human Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6 (LGR6) Interaktionspartner

1. Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro.

2. Lgr6 has a tumorpromoting role in the development of colorectal cancer.

3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance.

4. Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6.

5. LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing

6. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration.

Mouse (Murine) Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 6 (LGR6) Interaktionspartner

1. Leucine rich repeat containing G protein coupled receptor 6 (Lgr6) mRNA was found to be diminished in skin tumors.

2. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma whose expression is proportional with the disease progression.

3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance.

4. Lgr6 marks nail stem cells and is required for digit tip regeneration.

5. Lgr6 and Bmi1 have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 has a role in rapid cycling and maintance of sweat glands only

6. Lgr6 is expressed in cells at the basal area of taste buds in fungiform and circumvallate papillae. Lgr6+ cells give rise to taste bud cells in taste papillae in both anterior and posterior tongue.

7. The members of the R-spondin family are known as activators of Wnt signaling, and Lgr4, Lgr5, and Lgr6 have been identified as receptors for R-spondins.

8. Lgr5 has been identified as a marker of Wnt-regulated adult stem cell populations in the hair-follicle, intestine and stomach. A closely-related protein, Lgr6 marks adult stem cells responsible for fueling the renewal of the sebaceous gland and skin.[Review]

9. study concludes that Lgr6 marks the most primitive epidermal stem cell