Leucine-Rich PPR-Motif Containing Proteine (LRPPRC)

LRPPRC encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). Zusätzlich bieten wir Ihnen LRPPRC Antikörper (51) und LRPPRC Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LRPPRC 10128 P42704
Ratte LRPPRC LRPPRC 313867 Q5SGE0
LRPPRC 72416 Q6PB66
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top LRPPRC Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,376.85
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,376.85
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details

LRPPRC Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartnern

Human Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartner

  1. Knock-down of LRPPRC promotes apoptosis of hormone resistant prostate cancer cells.

  2. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation.

  3. To investigate the impact of the OXPHOS defect in the liver, aothors analyzed the mitochondrial phenotype in mice harboring an hepatocyte-specific inactivation of Lrpprc. Loss of LRPPRC in the liver caused a generalized growth delay, and typical histological features of mitochondrial hepatopathy.

  4. There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.

  5. LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA.

  6. High expression of ULK1 concomitant with high expression of LRPPRC may serve as useful markers for shorter biochemical progression (BCP)-free survival and overall survival in patients with metastatic prostate cancer (PCa) after androgen deprivation therapy (ADT).

  7. This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue

  8. LRPPRC knock-down in mammalian cells leads to an imbalance between mitochondria-encoded and nuclear-encoded subunits of complex IV

  9. study identifies LRPPRC as an important disease-causing gene in an early-onset, multisystem and neurological mitochondrial disease.

  10. LRPPRC levels were reduced in muscle cells and undetectable in liver from French Canadian Leigh Syndrome patients.

  11. LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance.

  12. Downregulation of LRPPRC expression resulted in the reduced expression of Bcl-2, upregulation of Bax, and cleaved caspase-9 and caspase-3. This induces apoptosis through the mitochondria-mediated pathway in PCa cells.

  13. LRPPRC functions as a checkpoint protein that prevents mitochondria from autophagy degradation and impact tumorigenesis.

  14. Tetherin binds with the mitochondrion-associated autophagy suppressor LRPPRC and prohibits its association with the autophagy initiation complex.

  15. LRPPRC overexpression is associated with gastric cancer.

  16. Data indicate that C14C10.4/MMA-1 Is the Structural and functional homolog of mammalian LRPPRC.

  17. LRPPRC therefore acts to suppress the initiation of basal levels of autophagy to clean up dysfunctional mitochondria and other cellular debris during the normal cell cycle.

  18. found that the tubulin-binding domain of NF1 is a binding partner of LRPPRC. Our findings provide clues to how loss or mutation of NF1 and LRPPRC may contribute to the manifestations of neurofibromatosis 1 and Leigh Syndrome, French Canadian variant.

  19. LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression.

  20. These data identify LRPPRC as a HIV-1 factor that is involved in HIV-1 replication through more than one mechanism.

Mouse (Murine) Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartner

  1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation.

  2. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins.

  3. both LRPPRC and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC-SLIRP complex.

  4. Ectopic expression of LRPPRC in the mouse liver completely interdicted non-alcoholic fatty liver disease, including inflammation.

  5. LRPPRC deficiency in Leigh syndrome causes an ATP synthase deficiency.

  6. LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression.

  7. Heart-specific Lrpprc disruption causes mitochondrial cardiomyopathy with drastic reduction in steady-state mitochondrial mRNA levels. LRPPRC forms an RNA-dependent protein complex needed to maintain a mitochondrial pool of non-translated mRNAs.

  8. These data strongly suggest that LRPPRC is involved in the maturation of cytochrome c oxidase (COX), and is involved in stabilizing of mitochondrial mRNAs encoding COX transcripts.

  9. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.

  10. Our results demonstrate that LIF signaling via the gp130/JAK/STAT3 pathway is required for the initiation of the astrogliosis-like reaction of retinal Muller cells after optic nerve injury.

  11. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~74%.

  12. LRP130 may function in stabilizing minisatellite DNA sequences.

  13. associates with mRNA/mRNP complexes at the outside of nuclear/endoplasmic reticulum, and plays a role in control of mRNA metabolisms

  14. These data link LRP130 and PGC-1alpha to defective hepatic energy homeostasis in Leigh syndrome French Canadian variant , and reveal a novel regulatory mechanism of glucose homeostasis.

  15. brown fat cell development common to both PGC-1 coactivators is governed by LRP130

LRPPRC Protein Überblick

Protein Überblick

This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome.

Genbezeichner und Symbole assoziert mit LRPPRC

  • leucine rich pentatricopeptide repeat containing (LRPPRC)
  • leucine-rich pentatricopeptide repeat containing (Lrpprc)
  • leucine-rich PPR-motif containing (Lrpprc)
  • 3110001K13Rik Protein
  • C76645 Protein
  • CLONE-23970 Protein
  • Gp130 Protein
  • Lrp130 Protein
  • Lrp157 Protein
  • Lsfc Protein

Bezeichner auf Proteinebene für LRPPRC

130 kDa leucine-rich protein , LRP 130 , leucine-rich PPR motif-containing protein, mitochondrial , leucine-rich PPR-motif containing , mitochondrial leucine-rich PPR motif-containing protein , leucine rich protein 157 , leucine-rich protein 157 , rLRP157 , leucine rich protein LRP130

GENE ID SPEZIES
10128 Homo sapiens
313867 Rattus norvegicus
72416 Mus musculus
Ausgewählte Anbieter für LRPPRC Proteine (LRPPRC)
Haben Sie etwas anderes gesucht?