Left-Right Determination Factor 2 Proteine (LEFTY2)

LEFTY2 encodes a member of the TGF-beta family of proteins. Zusätzlich bieten wir Ihnen LEFTY2 Antikörper (76) und LEFTY2 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LEFTY2 7044 O00292
LEFTY2 13590 Q64280
LEFTY2 289316  
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Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human Fc Tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$112.50
Details
Escherichia coli (E. coli) Maus His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$768.00
Details
Escherichia coli (E. coli) Ratte His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$768.00
Details
Mammalian Cells Human His tag   10 μg Anmelden zum Anzeigen 4 Days
$177.10
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$767.53
Details

LEFTY2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Left-Right Determination Factor 2 (LEFTY2) Interaktionspartnern

Human Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage.

  2. LEFTY2 down-regulates MKi67 (zeige MKI67 Proteine) expression and FAK (zeige PTK2 Proteine) activity, up-regulates miR (zeige MLXIP Proteine)-200a and E-cadherin (zeige CDH1 Proteine), and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  3. LEFTY2 regulates the expression and activity of ENaC (zeige SCNN1A Proteine) in endometrial epithelial cells via SGK1 (zeige SGK1 Proteine).

  4. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  5. Findings suggest that Lefty2 is negatively modulated by miR (zeige MLXIP Proteine)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  6. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  7. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  8. Addition of recombinant LEFTY-A to explants induced MMP-9 (zeige MMP9 Proteine) in most samples, a response prevented by ovarian steroids.

  9. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling.

  2. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (zeige DNMT3A Proteine) and DNMT3B (zeige DNMT3B Proteine); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (zeige HELLS Proteine) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  3. LEFTY2 regulates the expression and activity of ENaC (zeige SCNN1A Proteine) in endometrial epithelial cells via SGK1 (zeige SGK1 Proteine).

  4. Results indicate that microRNA miR (zeige MLXIP Proteine)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).

  5. exogenous lefty1 (zeige LEFTY1 Proteine) administered to mice restored the endogenous expression levels of lefty1 (zeige LEFTY1 Proteine). The present study demonstrated that lefty1 (zeige LEFTY1 Proteine) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (zeige TGFB1 Proteine) signaling pathway

  6. Lefty-1 (zeige LEFTY1 Proteine) may prevent TGFB1 (zeige TGFB1 Proteine)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (zeige SMAD3 Proteine), JNK-3 (zeige MAPK10 Proteine), and BMP-5 (zeige BMP5 Proteine) signaling.

  7. The expression of lefty in RCC (zeige XRCC1 Proteine) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (zeige XRCC1 Proteine).

  8. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  9. Taken together, these results suggest that optimal expression of Lefty1 (zeige LEFTY1 Proteine) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  10. Beta-catenin (zeige CTNNB1 Proteine) can recruit the H3K4me2/1 demethylase (zeige MBD2 Proteine) LSD1 (zeige KDM1A Proteine) to regulate the expression of the tumor suppressor Lefty1 (zeige LEFTY1 Proteine) in mouse embryonic stem cells.

Zebrafish Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.

  2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  3. we find that Cyclops is specifically required for the maintenance of lefty1 (zeige LEFTY1 Proteine) and lefty2 transcription

  4. study reports that microRNA-430 (miR (zeige MYLIP Proteine)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (zeige TGFB1 Proteine) Nodal antagonist lefty

LEFTY2 Protein Überblick

Protein Überblick

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit LEFTY2

  • left-right determination factor 2 (LEFTY2)
  • left right determination factor 1 (Lefty1)
  • lefty2 (lft2)
  • left-right determination factor 2 (Lefty2)
  • Left-right determination factor 2 (Lefty2)
  • left-right determination factor 2 (LOC699676)
  • left-right determination factor 2-like (LOC100232580)
  • 6030463A22Rik Protein
  • AI450052 Protein
  • atv2 Protein
  • AV214969 Protein
  • cb720 Protein
  • Ebaf Protein
  • Ebaf2 Protein
  • fe38b03 Protein
  • Lefta Protein
  • Leftb Protein
  • lefty Protein
  • lefty-1 Protein
  • LEFTYA Protein
  • Stra3 Protein
  • Tgfb4 Protein
  • wu:fe38b03 Protein

Bezeichner auf Proteinebene für LEFTY2

TGF-beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , transforming growth factor beta-4 , left-right determination factor 1 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , endometrial bleeding associated factor , left-right determination factor B , left-right determination, factor A , protein lefty-B , left-right determination factor 2 , lefty , left-right determination factor 2-like

GENE ID SPEZIES
7044 Homo sapiens
13590 Mus musculus
30146 Danio rerio
320202 Mus musculus
534018 Bos taurus
100337677 Sus scrofa
289316 Rattus norvegicus
395529 Gallus gallus
457780 Pan troglodytes
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
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