Left-Right Determination Factor 2 Proteine (LEFTY2)

LEFTY2 encodes a member of the TGF-beta family of proteins. Zusätzlich bieten wir Ihnen LEFTY2 Antikörper (83) und LEFTY2 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LEFTY2 7044 O00292
LEFTY2 13590 Q64280
LEFTY2 289316  
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Human Cells Human Fc Tag 50 μg 14 bis 16 Tage
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 bis 18 Tage
Human Cells Human His tag   10 μg 15 bis 16 Tage
Human Cells Human His tag   50 μg 4 Days
Escherichia coli (E. coli) Ratte His tag   100 μg 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag   100 μg 15 bis 18 Tage
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg 11 bis 18 Tage
Human Unkonjugiert   100 μg 6 Days

LEFTY2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Left-Right Determination Factor 2 (LEFTY2) Interaktionspartnern

Human Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. In a reaction-diffusion pattern, the effective range of Nodal is 3.5 times narrower than that of Lefty2.

  2. functional role of LEFTY during progesterone therapy for endometrial carcinoma

  3. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage.

  4. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration.

  5. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  6. Lefty A may account for the tumor suppressive activity of human adult stem cells.

  7. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.

  8. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation.

  9. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression

  10. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases

  11. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells

  12. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids.

  13. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.

Mouse (Murine) Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells

  2. Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling.

  3. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B; findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation

  4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1.

  5. Results indicate that microRNA miR-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).

  6. exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 signaling pathway

  7. Lefty-1 may prevent TGFB1-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3, JNK-3, and BMP-5 signaling.

  8. The expression of lefty in RCC cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC.

  9. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.

  10. Taken together, these results suggest that optimal expression of Lefty1 and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.

  11. Beta-catenin can recruit the H3K4me2/1 demethylase LSD1 to regulate the expression of the tumor suppressor Lefty1 in mouse embryonic stem cells.

  12. Lefty can antagonise TGF-beta1 mediated epithelial-mesenchymal transition in renal tubular epithelial cells.

  13. modulates both the induction of decidual differentiation and the maintenance of a decidualized state by an autocrine mechanism

  14. Cerberus-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation and regulate patterning of the primitive streak

  15. Regulated expression and spatial distribution of lefty in mouse endometrium confines its biological impact on tissues that undergo remodelling during estrous cycle and pregnancy.

  16. findings show that decidualized differentiation of stroma, which is a prerequisite for embryo implantation, leads to processing of lefty by PC5/6A

  17. The gene for Lefty1 protein, a Nodal antagonist that influences the direction of DVE migration, was found to be asymmetrically expressed in the primitive endoderm of the implanting blastocyst.

  18. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9.

Zebrafish Left-Right Determination Factor 2 (LEFTY2) Interaktionspartner

  1. Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.

  2. results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning

  3. we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription

  4. study reports that microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty

LEFTY2 Protein Überblick

Protein Überblick

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit LEFTY2

  • left-right determination factor 2 (LEFTY2)
  • left right determination factor 1 (Lefty1)
  • lefty2 (lft2)
  • left-right determination factor 2 (Lefty2)
  • Left-right determination factor 2 (Lefty2)
  • left-right determination factor 2 (LOC699676)
  • left-right determination factor 2-like (LOC100232580)
  • 6030463A22Rik Protein
  • AI450052 Protein
  • atv2 Protein
  • AV214969 Protein
  • cb720 Protein
  • Ebaf Protein
  • Ebaf2 Protein
  • fe38b03 Protein
  • Lefta Protein
  • Leftb Protein
  • lefty Protein
  • lefty-1 Protein
  • LEFTYA Protein
  • Stra3 Protein
  • Tgfb4 Protein
  • wu:fe38b03 Protein

Bezeichner auf Proteinebene für LEFTY2

TGF-beta-4 , endometrial bleeding-associated factor , left-right determination factor A , protein lefty-2 , protein lefty-A , transforming growth factor beta-4 , left-right determination factor 1 , left-right determination, factor B , protein lefty-1 , stimulated by retinoic acid gene 3 protein , endometrial bleeding associated factor , left-right determination factor B , left-right determination, factor A , protein lefty-B , left-right determination factor 2 , lefty , left-right determination factor 2-like

7044 Homo sapiens
13590 Mus musculus
30146 Danio rerio
320202 Mus musculus
534018 Bos taurus
100337677 Sus scrofa
289316 Rattus norvegicus
395529 Gallus gallus
457780 Pan troglodytes
699676 Macaca mulatta
100232580 Taeniopygia guttata
100435327 Pongo abelii
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