Laminin, gamma 1 Proteine (LAMC1)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Zusätzlich bieten wir Ihnen Laminin gamma 1 Antikörper (134) und Laminin gamma 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LAMC1 226519  
LAMC1 117036  
LAMC1 3915 P11047
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

LAMC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Rat (Rattus)

Human , , ,
, ,

Weitere Proteine zu Laminin, gamma 1 (LAMC1) Interaktionspartnern

Mouse (Murine) Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. netrin-4 disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain.

  2. epidermal laminin-511 is also a key regulator for later hair development and hair shaft differentiation.

  3. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1, GPBP, Lamc1, peroxidasin) during uterine reprogramming.

  4. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  5. Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes.

  6. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation.

  7. These findings document a pathogenic potential of antibodies targeting the laminin gamma1 N-terminus.

  8. LNgamma1-knockout mice present with intracerebral hemorrhage in adulthood.

  9. Laminins integrate scaffold-forming and cell-adhesion activities to assemble an endoneurial basement membrane.

  10. STI1 and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC-null mice.

  11. requirement of gamma1 laminins for assembly of the renal collecting duct system basement membrane, in which immobilized ligands act as solid-phase agonists to promote branching morphogenesis, growth and water transport functions

  12. Data show that expression of either mGluR1 or mGluR5 in HEK293 cells reconstituted the signaling pathways mediated by PrP(C)-Ln gamma1 peptide interaction.

  13. Laminin beta(1) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.

  14. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.

  15. structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5)

  16. Mice with reduced expression of laminin gamma1 in Schwann cells also exhibit a reduction in laminin alpha2 and beta1 and exhibit motor defects which lead to hind leg paralysis and tremor.

  17. This study demonstrates (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation. (2) that laminin provides a PI3-kinase/Akt-mediated Schwann cell survival signal.

  18. netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms

  19. The role of the laminin gamma1 chain for cardiac muscle differentiation and function using cardiomyocytes derived from embryonic stem cells deficient in the LAMC1 gene, was investigated.

  20. laminin regulates neurite growth and neuronal migration via integrin signaling through the AKT/GSK-3beta pathway

Zebrafish Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. Hh signaling is indirectly required via slow fiber specification for recovery of fast fiber elongation in laminin gamma1 mutant embryos

  2. Two zebrafish loci, grumpy and sleepy, encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.

Human Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. Polymorphism in the ERalpha gene is associated with an increased risk for advanced Pelvic Organ Prolapse. However, polymorphism in the LAMC1 gene does not seem to be associated with such risk.

  2. We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR-124 binding in hepatocellular carcinoma cells.

  3. Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in colorectal cancer (CRC) tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). These findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC susceptibility, and the exact biological mechanism awaits further research.

  4. The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1) locus showed suggestive association with disease.

  5. Our results show that miR-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2, ARHGAP18 and LAMC1, are negatively correlated with the expression of miR-181a. Moreover, high expression of ANGPT2 or LAMC1 together with large size of GBM is correlated with a shorter median overall survival

  6. miR-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1.

  7. Case Report: Anti-laminin-gamma 1 pemphigoid in patient with generalized pustular psoriasis and psoriasis vulgaris.

  8. The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1) as direct targets of miR-22 and miR-29a, respectively, suggested a tumor-suppressive role of these miRNAs.

  9. LAMC1 may contribute to the development and progression of uterine carcinoma, likely through enhancing tumor cell motility and invasion.

  10. Case Report: occurrence of anti-laminin-gamma1 pemphigoid in a case of autosomal recessive congenital ichthyosis.

  11. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146).

  12. Data showed that LAMC1 expression is directly regulated by miR-29s.

  13. These findings document a pathogenic potential of antibodies targeting the laminin gamma1 N-terminus.

  14. carbohydrate moiety (alpha-Gal) on laminin gamma-1 and collagen alpha-1 (VI) chain are possibly common IgE-reactive proteins in the Japanese patients with beef allergy

  15. results demonstrate that mutation in either NID1 or LAMC1 disrupts the interaction NID1-LAMC1 complex; findings implicate the extracellular matrix in the pathogenesis of Dandy-Walker spectrum disorders

  16. LAMC1 polymorphism could be a protective factor for SLE.

  17. Results suggest that laminin gamma1 expression is associated with meningioma grades and could play a role in enhancing tumor invasion.

  18. Genetic polymorphism of LAMC1 gene is associated in the pathogenesis of colorectal cancers.

  19. Letter: a small but distinct subgroup of both systemic and cutaneous lupus erythematosus patients has antibodies against the C-terminus of laminin gamma1.

  20. Autoantibodies in anti-p200 pemphigoid sera are pathogenic while pathogenicity is not mediated by autoantibodies against laminin gamma1.

Laminin gamma 1 (LAMC1) Protein Überblick

Protein Überblick

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

Genbezeichner und Symbole assoziert mit Laminin, gamma 1 Proteine (LAMC1)

  • putative laminin gamma-1 chain (Smp_163810)
  • laminin subunit gamma 1 (lamc1)
  • laminin, gamma 1 (Lamc1)
  • laminin subunit gamma 1 (Lamc1)
  • laminin, gamma 1 (lamc1)
  • laminin subunit gamma 1 (LAMC1)
  • B2e Protein
  • LAMB2 Protein
  • sly Protein

Bezeichner auf Proteinebene für Laminin, gamma 1 Proteine (LAMC1)

laminin gamma-1 chain , laminin subunit gamma-1 , S-LAM gamma , S-laminin subunit gamma , laminin B2 chain , laminin-1 subunit gamma , laminin-10 subunit gamma , laminin-11 subunit gamma , laminin-2 subunit gamma , laminin-3 subunit gamma , laminin-4 subunit gamma , laminin-6 subunit gamma , laminin-7 subunit gamma , laminin-8 subunit gamma , laminin-9 subunit gamma , shortstop , shp , sleepy

8355738 Schistosoma mansoni
100036631 Xenopus (Silurana) tropicalis
226519 Mus musculus
117036 Rattus norvegicus
286832 Danio rerio
3915 Homo sapiens
100734278 Cavia porcellus
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