Laminin, gamma 1 Proteine (LAMC1)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Zusätzlich bieten wir Ihnen Laminin gamma 1 Antikörper (133) und Laminin gamma 1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LAMC1 226519  
LAMC1 117036  
LAMC1 3915 P11047
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Showing 8 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$666.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$736.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 Days
$341.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

LAMC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Rat (Rattus)

Human , , ,
, ,

Weitere Proteine zu Laminin, gamma 1 (LAMC1) Interaktionspartnern

Mouse (Murine) Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. netrin-4 (zeige NTN4 Proteine) disrupts laminin networks and basement membranes through high-affinity binding to the laminin gamma-1 chain.

  2. epidermal laminin-511 (zeige LAMA5 Proteine) is also a key regulator for later hair development and hair shaft differentiation.

  3. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1 (zeige COL4A1 Proteine), GPBP (zeige COL4A3BP Proteine), Lamc1, peroxidasin) during uterine reprogramming.

  4. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (zeige NRG1 Proteine) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  5. Analysis of nidogen-1 (zeige NID1 Proteine) and laminin-gamma1 interaction reveals multiple binding modes.

  6. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 (zeige NID1 Proteine) mediate interactions complex formation.

  7. STI1 (zeige STIP1 Proteine) and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC (zeige PRNP Proteine)-null mice.

  8. Data show that expression of either mGluR1 (zeige GRM1 Proteine) or mGluR5 (zeige GRM5 Proteine) in HEK293 cells reconstituted the signaling pathways mediated by PrP(C (zeige PRNP Proteine))-Ln gamma1 peptide interaction.

  9. Laminin beta(1 (zeige LAMB1 Proteine)) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.

  10. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.

Zebrafish Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. Two zebrafish loci, grumpy (zeige LAMB1 Proteine) and sleepy, encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.

Human Laminin, gamma 1 (LAMC1) Interaktionspartner

  1. Polymorphism in the ERalpha (zeige ESR1 Proteine) gene is associated with an increased risk for advanced Pelvic Organ Prolapse. However, polymorphism in the LAMC1 gene does not seem to be associated with such risk.

  2. We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 (zeige CD151 Proteine) expression by competing for miR (zeige MLXIP Proteine)-124 binding in hepatocellular carcinoma cells.

  3. Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in colorectal cancer (CRC (zeige CALR Proteine)) tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). These findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC (zeige CALR Proteine) susceptibility, and the exact biological mechanism awaits further research.

  4. The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR (zeige GCKR Proteine)) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1) locus showed suggestive association with disease.

  5. Our results show that miR (zeige MLXIP Proteine)-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2 (zeige ANGPT2 Proteine), ARHGAP18 (zeige ARHGAP18 Proteine) and LAMC1, are negatively correlated with the expression of miR (zeige MLXIP Proteine)-181a. Moreover, high expression of ANGPT2 (zeige ANGPT2 Proteine) or LAMC1 together with large size of GBM is correlated with a shorter median overall survival

  6. miR (zeige MLXIP Proteine)-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1.

  7. Case Report: Anti-laminin-gamma 1 pemphigoid in patient with generalized pustular psoriasis and psoriasis vulgaris.

  8. The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1 (zeige MCL1 Proteine)) as direct targets of miR (zeige MLXIP Proteine)-22 and miR (zeige MLXIP Proteine)-29a, respectively, suggested a tumor-suppressive role of these miRNAs.

  9. LAMC1 may contribute to the development and progression of uterine carcinoma, likely through enhancing tumor cell motility and invasion.

  10. Case Report: occurrence of anti-laminin-gamma1 pemphigoid in a case of autosomal recessive congenital ichthyosis (zeige LBR Proteine).

Laminin gamma 1 (LAMC1) Protein Überblick

Protein Überblick

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

Genbezeichner und Symbole assoziert mit Laminin, gamma 1 Proteine (LAMC1)

  • putative laminin gamma-1 chain (Smp_163810)
  • laminin subunit gamma 1 (lamc1)
  • laminin, gamma 1 (Lamc1)
  • laminin subunit gamma 1 (Lamc1)
  • laminin, gamma 1 (lamc1)
  • laminin subunit gamma 1 (LAMC1)
  • B2e Protein
  • LAMB2 Protein
  • sly Protein

Bezeichner auf Proteinebene für Laminin, gamma 1 Proteine (LAMC1)

laminin gamma-1 chain , laminin subunit gamma-1 , S-LAM gamma , S-laminin subunit gamma , laminin B2 chain , laminin-1 subunit gamma , laminin-10 subunit gamma , laminin-11 subunit gamma , laminin-2 subunit gamma , laminin-3 subunit gamma , laminin-4 subunit gamma , laminin-6 subunit gamma , laminin-7 subunit gamma , laminin-8 subunit gamma , laminin-9 subunit gamma , shortstop , shp , sleepy

GENE ID SPEZIES
8355738 Schistosoma mansoni
100036631 Xenopus (Silurana) tropicalis
226519 Mus musculus
117036 Rattus norvegicus
286832 Danio rerio
3915 Homo sapiens
100734278 Cavia porcellus
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