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Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Zusätzlich bieten wir Ihnen Laminin gamma 1 Proteine (11) und Laminin gamma 1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Laminin gamma 1 Primary Antibody für IHC (p), WB - ABIN3043157
Chen, Wan, Xia, Guo, Wang, Liu, Li: Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V 2013
Show all 13 Pubmed References
Human Polyclonal Laminin gamma 1 Primary Antibody für IHC, IHC (p) - ABIN4330131
Kuhn, Kurman, Soslow, Han, Sehdev, Morin, Wang, Shih: The diagnostic and biological implications of laminin expression in serous tubal intraepithelial carcinoma. in The American journal of surgical pathology 2012
Human Polyclonal Laminin gamma 1 Primary Antibody für IHC, IHC (p) - ABIN4330132
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit (Col4a1 (zeige COL4A1 Antikörper), GPBP (zeige COL4A3BP Antikörper), Lamc1, peroxidasin) during uterine reprogramming.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (zeige NRG1 Antikörper) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
Analysis of nidogen-1 (zeige NID1 Antikörper) and laminin-gamma1 interaction reveals multiple binding modes.
The C-terminal domains of mouse laminin gamma 1 and nidogen 1 (zeige NID1 Antikörper) mediate interactions complex formation.
STI1 (zeige STIP1 Antikörper) and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC (zeige PRNP Antikörper)-null mice.
Data show that expression of either mGluR1 (zeige GRM1 Antikörper) or mGluR5 (zeige GRM5 Antikörper) in HEK293 cells reconstituted the signaling pathways mediated by PrP(C (zeige PRNP Antikörper))-Ln gamma1 peptide interaction.
Laminin beta(1 (zeige LAMB1 Antikörper)) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
structure of the interacting domains reveals a six-bladed Tyr (zeige TYR Antikörper)-Trp (zeige TYRP1 Antikörper)-Thr (zeige TRH Antikörper)-Asp (zeige C3 Antikörper) (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor (zeige EGF Antikörper)-like (LE) modules III3-5 in laminin (LE3-5)
This study demonstrates (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation. (2) that laminin provides a PI3-kinase (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)-mediated Schwann cell survival signal.
Two zebrafish loci, grumpy (zeige LAMB1 Antikörper) and sleepy, encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.
Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in colorectal cancer (CRC (zeige CALR Antikörper)) tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). These findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC (zeige CALR Antikörper) susceptibility, and the exact biological mechanism awaits further research.
The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR (zeige GCKR Antikörper)) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1) locus showed suggestive association with disease.
Our results show that miR (zeige MLXIP Antikörper)-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2 (zeige ANGPT2 Antikörper), ARHGAP18 (zeige ARHGAP18 Antikörper) and LAMC1, are negatively correlated with the expression of miR (zeige MLXIP Antikörper)-181a. Moreover, high expression of ANGPT2 (zeige ANGPT2 Antikörper) or LAMC1 together with large size of GBM is correlated with a shorter median overall survival
miR (zeige MLXIP Antikörper)-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1.
Case Report: Anti-laminin-gamma 1 pemphigoid in patient with generalized pustular psoriasis and psoriasis vulgaris.
The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1 (zeige MCL1 Antikörper)) as direct targets of miR (zeige MLXIP Antikörper)-22 and miR (zeige MLXIP Antikörper)-29a, respectively, suggested a tumor-suppressive role of these miRNAs.
LAMC1 may contribute to the development and progression of uterine carcinoma, likely through enhancing tumor cell motility and invasion.
Case Report: occurrence of anti-laminin-gamma1 pemphigoid in a case of autosomal recessive congenital ichthyosis (zeige LBR Antikörper).
Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (zeige MCAM Antikörper)).
Data showed that LAMC1 expression is directly regulated by miR (zeige MLXIP Antikörper)-29s.
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.
laminin gamma-1 chain
, laminin subunit gamma-1
, S-LAM gamma
, S-laminin subunit gamma
, laminin B2 chain
, laminin-1 subunit gamma
, laminin-10 subunit gamma
, laminin-11 subunit gamma
, laminin-2 subunit gamma
, laminin-3 subunit gamma
, laminin-4 subunit gamma
, laminin-6 subunit gamma
, laminin-7 subunit gamma
, laminin-8 subunit gamma
, laminin-9 subunit gamma