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The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. Zusätzlich bieten wir Ihnen Lactate Dehydrogenase A Antikörper (241) und Lactate Dehydrogenase A Proteine (56) und viele weitere Produktgruppen zu diesem Protein an.
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Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes
Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.
JMJD2A (zeige KDM4A ELISA Kits) regulated aerobic glycolysis by regulating LDHA expression. Therefore, the novel JMJD2A (zeige KDM4A ELISA Kits)-LDHA signaling pathway could contribute to the Warburg effects in NPC (zeige NPC1 ELISA Kits) progression.
The present study proved that HIF1 (zeige HIF1A ELISA Kits)/2alpha could activate LDHA expression in human pancreatic cancer cells, and high expression of LDHA promoted the growth and migration of pancreatic cancer cells.
Pretreatment LDH levels had noticeable prognostic value in advanced pancreatic ductal adenocarcinoma (PDAC) patients who received subsequent chemotherapy. Tackling elevated LDH levels before the initiation of chemotherapy might be a promising measure for improving overall survival of patients after treatment for their advanced PDAC.
Authors demonstrated that knock down of LDHA with siRNA or inhibition of LDHA activity with a LDHA specific inhibitor (FX-11), could sensitize PC-3RR cells to radiotherapy with reduced epithelial-mesenchymal transition, hypoxia, DNA repair ability and autophagy, as well as increased DNA double strand breaks and apoptosis.
Taken together, these results indicate that miR-142-3p could act as a tumor suppressor in HCC by targeting LDHA, suggesting new therapeutic targets for HCC treatment.
Findings suggest that miR (zeige MLXIP ELISA Kits)-34b-3 and miR (zeige MLXIP ELISA Kits)-449a suppress the development of nasopharyngeal carcinoma (NPC (zeige NPC1 ELISA Kits)) through regulation of glycolysis via targeting lactate dehydrogenase A.(LDHA) and may be potential therapeutic targets for the treatment of NPC (zeige NPC1 ELISA Kits).
Results provide evidence that miR (zeige MLXIP ELISA Kits)-200b acts as a tumor suppressor in glioma through the inhibition of LDHA both in vitro and in vivo.
our data demonstrate that overexpression of 14-3-3zeta (zeige YWHAZ ELISA Kits) in early stage pre-cancerous breast epithelial cells may trigger an elevated glycolysis and transcriptionally up-regulating LDHA, thereby contributes to human breast cancer initiation.
serum lactate dehydrogenase has a role in predicting the outcome of resected gastric cancer and construct prognostic nomograms for risk prediction
Upregulated KCNJ11 predicts a poor prognosis and is regulated by NFkappaB signaling in hepatocellular carcinoma (HCC). LDHA partially mediated the oncogenic roles of KCNJ11 in HCC.
Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling.
Results revealed that beta-arrestin-1 (zeige ARRB1 ELISA Kits) regulates lactate metabolism to contribute to beta2-adrenergic receptor (zeige ADRB2 ELISA Kits) functions in improved memory formation.
The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.
LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.
lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma (zeige IFNG ELISA Kits) expression independently of its 3'UTR (zeige UTS2R ELISA Kits).
LDHA is a direct target of miR (zeige MLXIP ELISA Kits)-34a in regulating glucose metabolism and tumor growth in breast cancer.
Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.
We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta (zeige TGFB1 ELISA Kits) to drive the fibrotic process.
High LDH-A expression is associated with metastases in breast tumors.
PGC-1alpha (zeige PPARGC1A ELISA Kits) reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene (zeige MYC ELISA Kits).
These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3 (zeige SLC2A3 ELISA Kits), LDHA, and SLC16A1 (zeige SLC16A1 ELISA Kits), which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.
The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.
Both LDHA and COPB1 were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.
lactate dehydrogenase A1
, L-lactate dehydrogenase A chain
, LDH muscle subunit
, lactate dehydrogenase C
, lactate dehydrogenase-A
, L-lactic acid dehydrogenase
, lactate dehydrogenase A
, M(A)-type lactate dehydrogenase
, lactate dehydrogenase-M
, cell proliferation-inducing gene 19 protein
, lactate dehydrogenase M
, proliferation-inducing gene 19
, renal carcinoma antigen NY-REN-59
, lactate dehydrogenase 1, A chain
, lactate dehydrogenase A4
, lactate dehydrogenase A-like