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The protein encoded by LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. Zusätzlich bieten wir Ihnen Lactate Dehydrogenase A Proteine (56) und Lactate Dehydrogenase A Kits (34) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Lactate Dehydrogenase A Primary Antibody für ICC, IF - ABIN4329691
Adochite, Moshnikova, Carlin, Guerrieri, Andreev, Lewis, Reshetnyak: Targeting breast tumors with pH (low) insertion peptides. in Molecular pharmaceutics 2014
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Human Monoclonal Lactate Dehydrogenase A Primary Antibody für ICC, IF - ABIN4329689
Pizzuto, Paventi, Porcile, Sarnataro, Daniele, Passarella et al.: l-Lactate metabolism in HEP G2 cell mitochondria due to the l-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate ... in Biochimica et biophysica acta 2012
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Cow (Bovine) Polyclonal Lactate Dehydrogenase A Primary Antibody für IHC, WB - ABIN2785876
Listerman, Bledau, Grishina, Neugebauer: Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. in PLoS genetics 2008
Molecular characterization and expression pattern of the equine lactate dehydrogenase A genes
Dynamic changes of LDH and HBDH activities may be useful in diagnosis of non-thermal low voltage electrical injury and in estimation of post injury intervals.
Taken together, these results indicate that miR (zeige MLXIP Antikörper)-142-3p could act as a tumor suppressor in HCC (zeige FAM126A Antikörper) by targeting LDHA, suggesting new therapeutic targets for HCC (zeige FAM126A Antikörper) treatment.
Findings suggest that miR (zeige MLXIP Antikörper)-34b-3 and miR (zeige MLXIP Antikörper)-449a suppress the development of nasopharyngeal carcinoma (NPC (zeige NPC1 Antikörper)) through regulation of glycolysis via targeting lactate dehydrogenase A.(LDHA) and may be potential therapeutic targets for the treatment of NPC (zeige NPC1 Antikörper).
Results provide evidence that miR (zeige MLXIP Antikörper)-200b acts as a tumor suppressor in glioma through the inhibition of LDHA both in vitro and in vivo.
our data demonstrate that overexpression of 14-3-3zeta (zeige YWHAZ Antikörper) in early stage pre-cancerous breast epithelial cells may trigger an elevated glycolysis and transcriptionally up-regulating LDHA, thereby contributes to human breast cancer initiation.
serum lactate dehydrogenase has a role in predicting the outcome of resected gastric cancer and construct prognostic nomograms for risk prediction
Upregulated KCNJ11 (zeige KCNJ11 Antikörper) predicts a poor prognosis and is regulated by NFkappaB (zeige NFKB1 Antikörper) signaling in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)). LDHA partially mediated the oncogenic roles of KCNJ11 (zeige KCNJ11 Antikörper) in HCC (zeige FAM126A Antikörper).
LDHA phosphorylation and activation provide pro-invasive, anti-anoikis and pro-metastatic advantages to cancer cells, suggesting that Y10 phosphorylation of LDHA may represent a promising therapeutic target and a prognostic marker for metastatic human cancers.
miR (zeige MLXIP Antikörper)-30a-5p may function as a tumor suppressor in breast cancer through the inhibition of LDHA expression and glycolysis.
Overexpression of LDHA can be a marker of poor prognosis in cholangiocarcinoma patients
LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells.
Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling.
Results revealed that beta-arrestin-1 (zeige ARRB1 Antikörper) regulates lactate metabolism to contribute to beta2-adrenergic receptor (zeige ADRB2 Antikörper) functions in improved memory formation.
The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1.
lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma (zeige IFNG Antikörper) expression independently of its 3'UTR (zeige UTS2R Antikörper).
LDHA is a direct target of miR (zeige MLXIP Antikörper)-34a in regulating glucose metabolism and tumor growth in breast cancer.
Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling.
We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta (zeige TGFB1 Antikörper) to drive the fibrotic process.
High LDH-A expression is associated with metastases in breast tumors.
PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene (zeige MYC Antikörper).
These findings indicated that heat shock (HS)-induced autophagy regulates lactate secretion by inhibiting apoptosis and increasing mRNA transcript and protein levels of SLC2A3 (zeige SLC2A3 Antikörper), LDHA, and SLC16A1 (zeige SLC16A1 Antikörper), which suggests that HS-induced autophagy may enhance lactate secretion by sertoli cells.
The NADH-cofactor binding site of pig heart LDH is involved in the interaction with acidic phospholipids, in the pig skeletal muscle LDH, neither the cofactor binding site nor the subunit interfacing areas seem to be involved in the interaction.
Both LDHA and COPB1 (zeige COPB1 Antikörper) were highly expressed in porcine skeletal muscle tissues, implying their potential regulatory function of muscle development.
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.
lactate dehydrogenase A1
, L-lactate dehydrogenase A chain
, LDH muscle subunit
, lactate dehydrogenase C
, lactate dehydrogenase-A
, L-lactic acid dehydrogenase
, lactate dehydrogenase A
, M(A)-type lactate dehydrogenase
, lactate dehydrogenase-M
, cell proliferation-inducing gene 19 protein
, lactate dehydrogenase M
, proliferation-inducing gene 19
, renal carcinoma antigen NY-REN-59
, lactate dehydrogenase 1, A chain
, lactate dehydrogenase A4
, lactate dehydrogenase A-like