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LHX1 encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. Zusätzlich bieten wir Ihnen LIM Homeobox 1 Antikörper (74) und LIM Homeobox 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4 (zeige WNT4 ELISA Kits), HNF1B (zeige HNF1B ELISA Kits), and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
Data have identified TBX6 as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation.
study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients
Data indicate that expression of ERAS, LHX1, and CCRK (zeige CDK20 ELISA Kits) is increased in aggressive subgroups of medulloblastomas.
Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling
Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities.
Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity.
findings establish that the developmental marker Lim1 acts as an oncogene (zeige RAB1A ELISA Kits) in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma
Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM (zeige PDLIM5 ELISA Kits) domains, which may participate in protein to protein interactions, and encodes a transcription factor.
Smad4 (zeige SMAD4 ELISA Kits)/Eomes (zeige EOMES ELISA Kits)-dependent Lhx1 expression in the epiblast marks the entire definitive endoderm lineage, the anterior mesendoderm, and midline progenitors.
LHX1 is required in the anterior mesendoderm, but not in the mesoderm, for formation of the head.
Lhx1 maintains synchrony among circadian oscillator neurons of the suprachiasmatic nucleus.
Lhx1 is necessary for SCN (zeige SRI ELISA Kits) terminal differentiation, including expression of neuropeptides profoundly important for circadian function.
OTX2 (zeige OTX2 ELISA Kits) has a role in regulating Dkk1 (zeige DKK1 ELISA Kits) and Lhx1 activity in the anterior mesendoderm
These studies identify LHX1 as the first transcription factor that is essential in the Mullerian duct epithelial progenitor cells for female reproductive tract development.
a core regulatory subcircuit composed of Pax2/8, Gata3 (zeige GATA3 ELISA Kits) and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
Lhx1 therefore may influence the localization of primordial germ cells by modulating Ifitm1-mediated repulsive activity.
The response of LMC motor neurons to Reelin (zeige RELN ELISA Kits) is gated by Foxp1 (zeige FOXP1 ELISA Kits)- and Lhx1-mediated regulation of expression of the critical Reelin (zeige RELN ELISA Kits) signalling intermediate Dab1 (zeige DAB1 ELISA Kits).
Inactivation of either PINCH isoform independently leads to instability of ILK, loss of stretch-responsive anf and vegf expression, and progressive heart failure
These results demonstrate an essential role for Lhx1 in driving specification of the entire kidney field from the intermediate mesoderm.
nephrogenic transcription factors (osr1, osr2, hnf1b (zeige HNF1B ELISA Kits), lhx1, pax8 (zeige PAX8 ELISA Kits))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (zeige INHBA ELISA Kits), retinoic acid
Substantial evidence is found for a prosomeric organization of the diencephalon based on alternating expression of Lhx1/5 and Lhx2 (zeige LHX2 ELISA Kits)/9 genes during larval development and in the adult.
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract.
LIM homeobox protein 1
, LIM/homeobox protein Lhx1
, homeobox protein Lim-1
, LIM homeo box protein 1
, domesticus (clone 2.3 kB) lim-1
, Homeobox protein LMX-2
, Homeobox protein Lim-1