anti-Kinesin Family Member 4A (KIF4A) Antikörper

Human Kinesin Family Member 4A (KIF4A) Interaktionspartner

1. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane

2. High KIF4A expression is associated with lung cancer.

3. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.

4. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable

5. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review)

6. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A.

7. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.

8. KIF4A might be a key regulator for tumoral progression in OSCCs.

9. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function.

10. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1.

11. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.

12. Abeta impairs the assembly and maintenance of the mitotic spindle. Mechanistically, these defects result from Abeta's inhibition of mitotic motor kinesins, including Eg5, KIF4A and MCAK.

13. KIF4 regulates midzone length during cytokinesis.

14. Loss of KIF4 expression is associated with gastric carcinoma.

15. Results demonstrating association of KIF4 with BRAF35 through the interaction of their respective alpha-helical coiled-coil domains is unique so far in mammals.

16. These results suggest that KIF4 is involved in cytokinesis, although direct evidence was not provided in this study.

17. KIF4 and its binding partner protein regulator of cytokinesis 1 play essential roles in the organization of central spindles and midzone formation

18. Human KIF4A is an essential chromosome-associated molecular motor involved in faithful chromosome segregation. HKIF4A localizes in the nucleoplasm during interphase and on condensed chromosome arms during mitosis.

19. role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis.

20. Zip1 and CR motifs are important for Kif4A chromatin-binding and its mitotic function.