anti-Kinesin Family Member 4A (KIF4A) Antikörper

Human Kinesin Family Member 4A (KIF4A) Interaktionspartner

1. these findings not only demonstrate that KIF4A contributes to colorectal carcinoma proliferation via modulation of p21-mediated cell cycle progression but also suggest the potential value of KIF4A as a clinical prognostic marker and target for molecular treatments.

2. Phosphorylated Kif4A (Kif4AWT) or Cdk phospho-mimetic Kif4A mutant (Kif4ATE) associated with chromosomes and condensin I (non-SMC subunit CAP-G and core subunit SMC2) to regulate chromosome condensation, spindle morphology, and chromosome congression/alignment in early mitosis.

3. AMPK and Aurora B competitively phosphoregulate KIF4A during mitotic phase due to overlapping recognition motifs, resulting in the elaborate phosphoregulation for KIF4A-dependent central spindle length control.

4. We found that KIF4A was dominantly regulated by FOXM1c among the four isoforms, and further identified KIF4A as a direct downstream target of FOXM1c. Inhibiting FOXM1 decreased KIF4A expression in hepatocellular carcinoma (HCC) cells, whereas its overexpression had the opposite effect.

5. KIF4A may act as a prognostic biomarker and potential therapeutic target in human Hepatocellular carcinoma.

6. The results revealed that circKIF4A and KIF4A could bind to miR-375 and that circKIF4A regulated the expression of KIF4A via sponging miR-375.

7. our novel results revealed that Cdk1-dependent KIF4A phosphorylation at S1186 is a trigger for chromosomal organization during early mitosis.

8. Here, the authors show that the collective activity of PRC1 and Kif4A results in relative microtubule sliding and concurrent end-tag formation on antiparallel microtubules.

9. This work identified KIF4A as a potential predictive and prognostic marker for hepatocellular carcinoma.

10. KIF4A promotes drug resistance of lung adenocarcinoma cells through transporting LRP-based vaults along microtubules towards the cell membrane

11. High KIF4A expression is associated with lung cancer.

12. decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.

13. Neither KIF4A nor condensin I alone can sufficiently accumulate on the chromosomal axis and confer physiological properties to chromosomes, thus establishing that the functions of KIF4A and condensin I are inseparable

14. Chromokinesin represents a kinesin superfamily regulating cell division through chromosome and spindle. (Review)

15. Hepatitis B virus activates the KIF4A gene promoter and upregulates the mRNA and protein expression of KIF4A.

16. KIF4A and PP2A-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.

17. KIF4A might be a key regulator for tumoral progression in OSCCs.

18. Genetic association of KIF4A and KIF5C mutations in intellectual disability and synaptic function.

19. The KIF4A phosphorylation by Aurora B stimulates the maximal microtubule-dependent ATPase activity of KIF4A and promotes its interaction with PRC1.

20. Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length.