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KIF11 encodes a motor protein that belongs to the kinesin-like protein family. Zusätzlich bieten wir Ihnen KIF11 Antikörper (135) und KIF11 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human KIF11 Protein expressed in HEK-293 Cells - ABIN2724227
Drosopoulos, Tang, Chao, Linardopoulos: APC/C is an essential regulator of centrosome clustering. in Nature communications 2014
These data demonstrate the functional interplay between PTEN and EG5 in controlling mitotic spindle structure and chromosome behaviour during mitosis.
the RNF20 (zeige RNF20 Proteine)/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates in spindle assembly.
Stability of protein-ligand complexes were analyzed using molecular dynamic simulations. Our studies suggest that pyridazine analogs have good MDCK, permeability properties and high binding affinity to the human Eg5.
These results illustrate how a posttranslational modification of a kinesin can be used to fine tune motor behavior to meet specific physiological needs.
Immunohistochemical analysis demonstrated that KIF11 was expressed in 64 of 99 (64.6%) oral cancer tissues but not in healthy oral epithelia. Strong KIF11 expression was significantly associated with poor prognosis among oral cancer patients (P=0.034), and multivariate analysis confirmed its independent prognostic value.
Results identified 7 novel KIF11 mutations during the screening of 142 patients with familial exudative vitreoretinopathy (FEVR (zeige NDP Proteine)), and further confirmed that KIF11 is causative of FEVR (zeige NDP Proteine) in an autosomal dominant manner.
results demonstrate that Eg5 is phosphorylated in cultured cells by Src (zeige SRC Proteine) family kinases (SFKs) at three sites in the motor head: Y125, Y211, and Y231. Mutation of these sites diminishes motor activity in vitro, and replacement of endogenous Eg5 with phosphomimetic Y211 in LLC-Pk1 (zeige PKLR Proteine) cells results in monopolar spindles, consistent with loss of Eg5 activity.
Results show that KIF11 mRNA expression was upregulated in prostate cancer tissues and associated with aggressive characteristics.
Eg5 is overexpressed in the livers of the hepatocellular carcinoma patients and is predictive of poor prognosis.
The data suggested that Eg5 may be identified as a novel prognostic biomarker and targeting Eg5 seems to be a novel strategy for LSCC treatment.
Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.
that Pten, through the Dlg1 (zeige DLG1 Proteine)-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Fbxo30 (zeige FBXO30 Proteine)-Eg5 interaction as a critical checkpoint in mammopoiesis.
Data show that the STIM1 (zeige STIM1 Proteine) Ksp (Eg5)-cre knockout mice produced more urine compared to control.
Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.
Disruption of the in vivo interaction of KIF11 with ZBP1 (zeige ZBP1 Proteine) delocalizes beta-actin (zeige ACTB Proteine) mRNA and affects cell migration.
These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells.
incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5.
Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG (zeige PAEP Proteine), the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA.
These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention.
observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 (zeige DAZL Proteine) resulted in end-directed Eg5 movement.
Data show that the kinesin 5 (Eg5) binding time has less sensitivity on MCF7 as compared to bovine brain microtubules.
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
TR-interacting protein 5
, kinesin-like protein 1
, kinesin-like protein KIF11
, kinesin-like spindle protein HKSP
, kinesin-related motor protein Eg5
, thyroid receptor-interacting protein 5
, kinesin 11
, kinesin-like 1