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The sarcoplasmic reticulum (SR) is an intracellular membrane compartment that controls intracellular calcium concentration and therefore plays a role in excitation-contraction coupling.
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Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles.
Ca(2 (zeige CA2 ELISA Kits)+) transients evoked by tetanic stimulation are the result of massive Ca(2 (zeige CA2 ELISA Kits)+) influx due to enhanced Ca(v)1.1 (zeige CACNA1S ELISA Kits) channel activity, which restores muscle strength in JP45/CASQ1 (zeige CASQ1 ELISA Kits) double knockout mice.
Data indicate that the presence of either one of these JP-45 variants decreased the sensitivity of the dihydropyridine receptor (zeige CACNA1S ELISA Kits) DHPR (zeige QDPR ELISA Kits) to activation.
The results may be explained by a modulatory effect of JP-45 related to its reported in vitro interaction with the dihydropyridine receptor (zeige CACNA1S ELISA Kits) and the SR Ca(2+) binding protein (zeige PVALB ELISA Kits) calsequestrin (CSQ (zeige CASQ1 ELISA Kits)).
The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle.
junctional sarcoplasmic reticulum protein 1
, junctional-face membrane protein of 45 kDa homolog
, homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45
, skeletal muscle sarcoplasmic reticulum protein JP-45