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ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane.
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Apoptosis, but not autophagy, that is induced via p21 (zeige CDKN1A ELISA Kits)-activated BNIP3 (zeige BNIP3 ELISA Kits) expression accounts for the efficacy of ICMT inhibition in sensitive pancreatic cancer cells in both in vitro and in vivo models. In contrast, cells resistant to ICMT inhibition demonstrated no mitochondria dysfunction or p21 (zeige CDKN1A ELISA Kits) signaling changes under ICMT suppression
ICMT catalyzed carboxylmethylation is critical for RAB4A activation and interaction with effectors, its localization to endosomes and recycling vesicles, and hence important for RAB4A-dependent integrin beta3 recycling to plasma membrane.
ICMT function is critical for the tumorigenesis capacity of naturally occurring mutant KRAS human cancer cells.
simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.
impact of Icmt on tumorigenic processes
Silencing ICMT in osteosarcoma cells decreas (zeige NOTCH1 ELISA Kits)ed Notch1 signaling in (zeige PDX1 ELISA Kits)response to stimulation with cell-surface ligands.
a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.
modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells
ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.
findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (zeige RACGAP1 ELISA Kits) methylation and activation and its downstream antiapoptotic signaling pathway.
ICMT deficiency precisely phenocopied Notch1 (zeige NOTCH1 ELISA Kits) deficiency in the Pdx1 (zeige PDX1 ELISA Kits)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (zeige WNT2 ELISA Kits) signaling.
inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.
ICMT inhibition induces endothelial cell apoptosis through GRP94 (zeige HSP90B1 ELISA Kits)
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.
prenylated protein carboxyl methyltransferase
, prenylcysteine carboxyl methyltransferase
, protein-S isoprenylcysteine O-methyltransferase
, protein-S-isoprenylcysteine O-methyltransferase
, farnesyl cysteine carboxyl methyltransferase
, prenylcysteine carboxyl methlytransferase
, isoprenylcysteine carboxyl methyltransferase
, Isoprenylcysteine carboxyl methyltransferase