anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Antikörper

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Zusätzlich bieten wir Ihnen ISCU Proteine (8) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ISCU 23479 Q9H1K1
ISCU 288740  
ISCU 66383 Q9D7P6
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Top anti-ISCU Antikörper auf antikoerper-online.de

Showing 10 out of 56 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Iscu Antibody Titration: 1.0 ug/ml Positive Control: Rat Lung 100 μL 2 bis 3 Tage
$289.00
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, WB ABIN6273002 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from rat spleen, using ISCU antibody. Lane 1 was treated with the blocking peptide. 100 μL 11 bis 12 Tage
$390.77
Details
Human Maus Unkonjugiert IF, ELISA, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell. [antibody concentration 10 ug/ml] NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60 . 100 μg 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in WiDr cell line lysates (35ug/lane). Western blot analysis in mouse lung tissue lysates (35ug/lane). 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of mouse lung, using ISCU antibody (ABIN5972597). 100 μL 11 bis 16 Tage
$426.40
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cell lines, using ISCU Antibody. 200 μL 12 bis 14 Tage
$438.90
Details
Human Maus Unkonjugiert IHC, IHC (p), WB   100 μL 11 bis 14 Tage
$522.50
Details
Human Maus Unkonjugiert WB   100 μL 11 bis 14 Tage
$522.50
Details
Human Maus Unkonjugiert WB Western Blot analysis of ISCU expression in transfected 293T cell line by ISCU MaxPab polyclonal antibody.Lane 1: NIFUN transfected lysate(15.62 KDa).Lane 2: Non-transfected lysate. 50 μg 11 bis 12 Tage
$440.00
Details

Am meisten referenzierte anti-ISCU Antikörper

  1. Human Monoclonal ISCU Primary Antibody für IF, ELISA - ABIN565100 : Heather, Cole, Tan, Ambrose, Pope, Abd-Jamil, Carter, Dodd, Yeoh, Schofield, Clarke: Metabolic adaptation to chronic hypoxia in cardiac mitochondria. in Basic research in cardiology 2012 (PubMed)

Weitere Antikörper gegen ISCU Interaktionspartner

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaktionspartner

  1. Study reports 3.2 A resolution cryo-electron microscopy structure of the FXN-bound active human iron-sulfur clusters biosynthesis complex. FXN binds at the interface of two NFS1 and one ISCU subunits, modifying the local environment of a bound zinc ion that would otherwise inhibit NFS1 activity in complexes without FXN.

  2. identifies an important regulatory role for zinc-bound ISCU in modulation of the human Fe-S assembly system in vitro and reports no 'FXN bypass' effect on mutations at position Met140 in human ISCU

  3. we report the first heterozygous dominant mutation in ISCU; notably, this alteration resulted in a similar phenotype as the recessive ISCU disease previously described.

  4. When ISCU was replaced by the fully structured variant ISCU(M108I), the addition of rdFDX2 to the [NIA-ISCU(M108I)-FXN]2 complex led to the release of FXN. Thus, the displacement of FXN by rdFDX2 explains the failure of FXN to stimulate Fe-S cluster assembly on ISCU(M108I).

  5. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  6. The NFS1/ISD11 complex further interacts with scaffold protein ISCU and regulator protein frataxin, thereby forming a quaternary complex for Fe-S cluster formation.

  7. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN(42-210)]24.[NFS1]24.[ISD11]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  8. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  9. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  10. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  11. IscU is a new substrate of MK2 both in Drosophila cells and in human cells

  12. Fe-S assembly protein (ISCU2) and frataxin convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  13. the G50E iron-sulfur cluster scaffold protein (ISCU) mutation has a role in mitochondrial myopathy

  14. NFS1 binds preferentially to the D-state of ISCU while mtHSP70 binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU.

  15. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  16. MicroRNA-210 correlates negatively with its gene target ISCU at the protein and mRNA level. MicroRNA-210 correlated with positive outcome variables

  17. ISCU protein deficiency in patients results from muscle-specific mis-splicing and oxidative stress.

  18. this study unveiled a signaling axis of HIF-1alpha/miRNA-210/iron-sulfur cluster scaffold protein in a subset of head and neck paragangliomas that could have an impact on SDHB protein stability by a mechanism independent of succinate dehydrogenase mutations

  19. Photoreactive heterotrifunctional chemical cross-linking confirmed the interaction between frataxin and ISCU in the presence of iron and validated that transient interactions can be covalently trapped with this method.

  20. The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaktionspartner

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma alone induced Nfs1 protein instability, LPS triggered a delayed decline of Nfs1, rather involving transcriptional events or mRNA instability.

  6. Results identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210.

ISCU Antigen-Profil

Protein Überblick

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Genbezeichner und Symbole assoziert mit ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130) Antikörper
  • iron-sulfur cluster assembly enzyme (ISCU) Antikörper
  • iron-sulfur cluster assembly enzyme a (iscua) Antikörper
  • iron-sulfur cluster assembly enzyme (Iscu) Antikörper
  • 2310020H20Rik Antikörper
  • AA407971 Antikörper
  • HML Antikörper
  • hnifU Antikörper
  • ISU2 Antikörper
  • Nifu Antikörper
  • Nifun Antikörper
  • RGD1309562 Antikörper
  • si:ch211-191d15.3 Antikörper
  • zC191D15.3 Antikörper

Bezeichner auf Proteinebene für ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPEZIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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