Inversin Proteine (INVS)

INVS encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. Zusätzlich bieten wir Ihnen Inversin Antikörper (17) und Inversin Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
INVS 27130 Q9Y283
INVS 16348 O89019
Ratte INVS INVS 313228  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

INVS Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu Inversin (INVS) Interaktionspartnern

Xenopus laevis Inversin (INVS) Interaktionspartner

  1. Inversin relays Frizzled-8 (zeige FZD8 Proteine) signals to promote proximal pronephros development.

  2. The present study indicates that calmodulin binding sites (IQ motifs) are crucial in controlling the biological activity of both mouse and Xenopus inv proteins

Human Inversin (INVS) Interaktionspartner

  1. Collectively, these results indicated that inversin might promote the tumorigenicity of lung cancer cells and serve as a novel therapeutic target of non-small cell lung cancer.

  2. Akt (zeige AKT1 Proteine) phosphorylates inversin at amino acids 864-866 that are required not only for Akt (zeige AKT1 Proteine) interaction, but also for inversin dimerization.

  3. Truncating mutations in NPHP2 gene is associated with nephronophthisis-related ciliopathy.

  4. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (zeige NEK9 Proteine), INVS and NPHP3 (zeige NPHP3 Proteine).

  5. INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.

  6. has conserved ankyrin repeat and IQ domains and interacts with calmodulin

  7. analysis of a homozygous mutation in exon 13 of inversin (INVS) (C2719T, R907X) in a patient with retinitis pigmentosa and renal failure [case report]

  8. Thus, although considered a common variant, inv(10)(p11.2q21.2) has a single ancestral founder among northern Europeans.

  9. Cystic kidney disease has been linked to mutations in the Invs gene in mice with an inversion of embryonic turning (inv/inv) and the INVS (NPHP2) gene in human infantile nephronophthisis (NPH).

  10. screened 43 families with infantile nephronophthisis (ESRD less than 5 years of age) for NPHP2 and NPHP3 (zeige NPHP3 Proteine) mutations and determined genotype-phenotype correlations

Mouse (Murine) Inversin (INVS) Interaktionspartner

  1. We constructed sub-congenic lines to more specifically localize the modifier and have determined it resides in a 3.2 Mb interval containing 28 genes. These include Invs and Anks6, which are both excellent candidates for the modifier as mutations in these genes result in PKD (zeige PRKD1 Proteine) and both genes are known to genetically and physically interact with Nek8 (zeige NEK8 Proteine).

  2. Ciliary abnormalities are associated with nphp2 mutant mice.

  3. Loss of NPHP2 causes ciliogenesis defects.

  4. the significance of Inversin in controlling cell migration processes

  5. Nek8 (zeige NEK8 Proteine) acts downstream of Inv function

  6. Inv acts as a molecular anchor for Nphp3 (zeige NPHP3 Proteine) and Nek8 (zeige NEK8 Proteine) in the proximal segment of primary cilia.

  7. the inv gene product functions in several cellular compartments, including the nucleus and cell-cell adhesion sites

  8. Molecular cloning of a gene for inversion of embryo turning (inv) with cystic kidney. Deduced amino acid sequence shows 15 successive repeats of Ank (zeige ANKH Proteine)/Swi6 motif in its N-terminal domain. Mutation causes situs inversus and cysts in kidney in inv mutant.

  9. inv has a role in kidney disease: inv mutant mouse has renal cysts resembling infantile NPHP2

  10. The localization of inversin in distal tubules in the kidney and in extrarenal tissues suggests that the expression of this protein has an important function in a variety of organs.

Zebrafish Inversin (INVS) Interaktionspartner

  1. Nek8 (zeige NEK8 Proteine) acts downstream of Inv function

Inversin (INVS) Protein Überblick

Protein Überblick

This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit Inversin Proteine (INVS)

  • inversin S homeolog (invs.S)
  • inversin (INVS)
  • inversin (Bm1_38710)
  • inversin (PTRG_09181)
  • Inversin (EAMY_RS33690)
  • inversin (LOAG_11716)
  • inversin (invs)
  • inversin (Invs)
  • INV Protein
  • INVS Protein
  • invs-a Protein
  • MGC140477 Protein
  • NPH2 Protein
  • Nphp2 Protein
  • RGD1563359 Protein
  • wu:fe47e11 Protein

Bezeichner auf Proteinebene für Inversin Proteine (INVS)

inversin , inversion of embryo turning homolog , inversion of embryonic turning , nephrocystin-2 , inversion of embryo turning protein , nephrocystin 2

378491 Xenopus laevis
473146 Pan troglodytes
529698 Bos taurus
6102626 Brugia malayi
6347469 Pyrenophora tritici-repentis Pt-1C-BFP
8912192 Erwinia amylovora CFBP1430
9949175 Loa loa
100010929 Monodelphis domestica
100075447 Ornithorhynchus anatinus
100144697 Xenopus (Silurana) tropicalis
100344027 Oryctolagus cuniculus
100453593 Pongo abelii
100594079 Nomascus leucogenys
27130 Homo sapiens
16348 Mus musculus
313228 Rattus norvegicus
395234 Gallus gallus
442950 Canis lupus familiaris
245946 Danio rerio
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