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The protein encoded by ILF2 is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. Zusätzlich bieten wir Ihnen ILF2 Antikörper (95) und ILF2 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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ILF2 interacts with RNA-binding proteins involved in the DNA damage response.
The data suggest that features of both the N- and C-termini of NF90 (zeige MMP4 ELISA Kits) participate in the heterodimerization with NF45 and that the formation of NF90 (zeige MMP4 ELISA Kits)-NF45 changes the conformation of NF90 (zeige MMP4 ELISA Kits)'s RNA-binding motifs to a status in which the co-operative interplay of the RNA-binding motifs is optimal.
NF90 (zeige MMP4 ELISA Kits)-NF45 stimulates an elevation of EGF receptor (zeige EGFR ELISA Kits) levels via the suppression of miR-7 (zeige LILRB1 ELISA Kits) biogenesis, resulting in the promotion of cell proliferation in Hepatocellular Carcinoma.
The results revealed that ILF2 is regulated by miR-7 (zeige LILRB1 ELISA Kits) and suggest that downregulation of miR-7 (zeige LILRB1 ELISA Kits) may be an important factor for the ILF2 overexpression in pancreatic carcinoma.
Deletion of the RNA binding domains of NF45 and NF90 (zeige MMP4 ELISA Kits) diminished the enhancement of HIV infection and gene expression.
NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma.
Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis
The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.
NF45 and NF90 (zeige MMP4 ELISA Kits) are novel higher-eukaryote-specific factors required for the maturation of 60S ribosomal subunits.
These findings suggested that NF45 might play an important role in promoting the tumorigenesis of ESCC, and thus be a promising therapeutic target to prevent ESCC progression.
Data support a model in which NF45, NF90 (zeige MMP4 ELISA Kits), and NF110 (zeige MMP4 ELISA Kits) operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues.
NF90 (zeige MMP4 ELISA Kits)-NF45 complex induces centronuclear myopathy through increased dynamin 2 (zeige DNM2 ELISA Kits) expression by an NF90 (zeige MMP4 ELISA Kits)-NF45-induced reduction of miR (zeige MLXIP ELISA Kits)-133a expression in vivo.
Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin
we propose that NF45 and NF90 have the potential to activate SP-10 gene transcription, and that a chromatin modification event must occur first in order to provide access to these transcription factors.
The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14.
interleukin enhancer binding factor 2, 45kDa
, interleukin enhancer-binding factor 2 homolog
, interleukin enhancer-binding factor 2-like
, interleukin enhancer binding factor 2, 45kD
, interleukin enhancer-binding factor 2
, nuclear factor of activated T-cells, 45-kDa
, nuclear factor of activated T-cells 45 kDa
, testis expressed gene 267
, liver regeneration-related protein LRRG031