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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Zusätzlich bieten wir Ihnen IL27 Antikörper (166) und IL27 Kits (53) und viele weitere Produktgruppen zu diesem Protein an.
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Human IL27 Protein expressed in Wheat germ - ABIN1307800
Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 2 Pubmed References
This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population
Data point out to a broad set of activities shared by IL-27 and IFN-gamma (zeige IFNG Proteine), which are dependent on the common activation of the STAT1 (zeige STAT1 Proteine) pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation
The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis
this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1 (zeige IL27RA Proteine)) on fetal membranes in cases of preterm birth
results indicate that elevated IL-27 strongly correlates with EOS (zeige IKZF4 Proteine) and may provide additional diagnostic value along with PCT (zeige UROD Proteine).
serum interleukin-27 and interleukin-35 concentrations in patients with Guillain-Barre syndrome
Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (zeige IRF6 Proteine)cardial dysfunction compared with that in controls.
IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.
IL-27 increased NLRP3 (zeige NLRP3 Proteine) inflammasome activation in monocytes with enhanced release of IL-1 beta (zeige IL1B Proteine).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
TTP (zeige ZFP36 Proteine), encoded by Zfp36 (zeige ZFP36 Proteine), degrades p28 (zeige GSTO1 Proteine) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (zeige TXNRD1 Proteine)-like cells in celiac disease
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (zeige TP53 Proteine) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (zeige LTF Proteine).
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (zeige TLR4 Proteine) injection compared with control specimens.
these findings highlight critical roles for IFN-gamma (zeige IFNG Proteine) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation
IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (zeige EOMES Proteine) and Blimp1 (zeige PRDM1 Proteine).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (zeige IL6 Proteine) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit