Interleukin 17A Proteine (IL17A)

The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Zusätzlich bieten wir Ihnen IL17A Antikörper (411) und IL17A Kits (127) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IL17A 3605 Q16552
IL17A 16171 Q62386
IL17A 301289  
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Top IL17A Proteine auf

Showing 10 out of 98 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus Unkonjugiert 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Escherichia coli (E. coli) Ratte Unkonjugiert 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Maus Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human Unkonjugiert   25 μg Anmelden zum Anzeigen 10 bis 12 Tage

IL17A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
, , ,
Mouse (Murine) , , , , , ,

Rat (Rattus) ,

Am meisten referenzierte IL17A Proteine

  1. Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453 : Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010 (PubMed)
    Show all 3 Pubmed References

  2. Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456 : Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011 (PubMed)

  3. Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899 : Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016 (PubMed)

Weitere Proteine zu Interleukin 17A (IL17A) Interaktionspartnern

Human Interleukin 17A (IL17A) Interaktionspartner

  1. Serum levels were elevated in diabetic Hepatitis C Virus infected patients.

  2. a significant increase of miR26a & IL17 occurs in relapsing - remitting Multiple Sclerosis patients

  3. allergen specific immunotherapy decreases IL-17 and increases IL-35 in patients with AR sensitive to house dust mite allergens

  4. IL-17 induces recruitment and functional activity of granulocytes in coinfected with schistosomiasis and hepatitis C virus which may contribute to the progress of fibrosis.

  5. Results show that IL-17A expression, and IL-17R are increased in neutrophils of autism spectrum disorder (ASD) patients. Further, inflammatory signaling pathways such as such as phospho-NFkappaB, and ROS generating enzymes, i.e. NOX2/iNOS are increased in neutrophils of ASD patients.

  6. Mucosal-associated invariant T interleukin 17 (MAITMAIT-17 are present in children with asthma and associated with asthma symptoms.

  7. The expression pattern of the IL-17A in chronic obstructive pulmonary distress syndrome samples was increased as compared of those of normal samples, and their main role in the regulation of and p53-fibrinolytic system makes these components as a predictive prominent component in smokers with COPD.

  8. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

  9. In anklylosing spondylitis patients, IL-17A regulates osteoblast activity and cell differentiation via JAK2/STAT3 signaling.

  10. IL-17A rs2275913 polymorphism is involved in the development of OA in Chinese Han population.

  11. The interleukins IL-23/IL-17 immune axis has been detected as an important factor in the immunopathogenesis of ankylosing spondylitis (AS) [Review].

  12. Our results suggest that enhanced CXCR4 expression on CD4+ T-cells was positively correlated with increased plasma IL-17A concentrations in patients with AA. In addition, the level of CXCR4 expression on T-cells and IL-17A concentration were both positively correlated with AA severity.

  13. confirm that IL-9 promotes inflammation in psoriasis by up-regulating IL-17A production

  14. expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer; data suggest that IL-17A, E, F and their receptors IL-17RA, RB, RC may be involved in the pathogenesis of non-small cell lung cancer

  15. It appears to be associated with the metastasis-prone phenotype of oral squamous cell carcinoma.

  16. Taken together, this study suggests that FGF2 cooperates with IL-17 to promote the pathogenesis of autoimmune arthritis by cooperating with IL-17 to induce inflammatory response.

  17. These findings suggest that Foxp3(+) cells, IL-10 and IL-17 play important roles in the immunopathogenesis of cutaneous leishmaniasis and that these roles differ depending on the causal leishmania species and different body compartments.

  18. Our data indicate that a distinct inflammatory process accompanies IL17A and CD21L co-expression. Clearly B-cells are involved and their prominence indicates that therapies targeting B-cells, such as rituximab, are likely to be more efficacious towards IL17A+/CD21L+ synovia.

  19. IL-17, a pro-inflammatory cytokine, mostly secreted by infiltrated CD4(+) T helper cells, has shown to mediate resistance to anti-VEGF therapies, through recruiting bone marrow derived cells and modulating stromal cells activities including endothelial cells, tumor associated macrophages and cancer associated fibroblasts. [review]

  20. Our results suggest that the TT genotype of IL-17A rs3748067 might be a risk factor for TB in Asians; the A allele, as well as the AG and AA+AG genotypes of the rs2275913 polymorphism, might be protective against TB in Caucasians

Horse (Equine) Interleukin 17A (IL17A) Interaktionspartner

  1. Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO) horses.

  2. cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells

  3. This study examined effects of in vitro exposure to solutions of hay dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

  4. The acute pulmonary neutrophilia characteristic of recurrent airway obstruction was not associated with an increase in expression of chemokines in pulmonary mononuclear cells from disease-susceptible horses.

Mouse (Murine) Interleukin 17A (IL17A) Interaktionspartner

  1. Interleukin-17 (IL-17) produced by locally differentiating TH17 cells is an important driver of the activation of inflamed lymph node stromal cells.

  2. IL-17A aggravates inflammatory response during Acute myocardial infarction by inducing macrophages infiltration and activating NLRP3 inflammasome through AMPKalpha/p38MAPK/ERK1/2 pathway.

  3. that IL-17A is involved in inflammation-evoked mechanical hyperalgesia in AIA even though the inflammatory process is not dependent on IL-17A. Thus the beneficial clinical effect of IL-17A neutralisation in some forms of arthritis is likely to result not only from the interference with the inflammatory process but also from the interference with processes of nociception.

  4. IL-17 acts an inhibitory factor in TGF-beta-induced renal fibroblast activation and extracellular matrix synthesis, and sequentially in renal interstitial fibrosis, via down-regulation of Smad-independent pathway (p38MAPK and AKT phosphorylations).

  5. involved in the development of intestinal fibrosis through inducing epithelial-mesenchymal transition

  6. Coxiella downregulates IL-17 signaling in a T4BSS-dependent manner in order to escape the macrophage immune response.

  7. The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.

  8. Mortality is higher and occurs at an early stage of infection in the interleukin (IL)-17A-knockout mice than in the wild-type and IL-17A/F-knockout mice; however, there is no significant difference in the intrapulmonary bacterial counts among the three groups. The IL-17A-knockout group shows higher levels of IL-17F and granulocyte-colony stimulating factor and higher neutrophil count in the bronchoalveolar lavage fluid.

  9. Resulted in severe and irreversible disease that, unlike EAE-I, was not abolished by anti-IL-17-mAb.

  10. Study in mouse skin wound model found that Vgamma4 T cells were a major source of epidermal IL-17a at the early stages of wounding and were responsible for the delayed wound repair. Moreover, Vgamma4 T cell-derived IL-17a indirectly inhibited Igf-1 production in dendritic epidermal T cells by enhancing epidermal IL-23/IL-1beta expression.

  11. Neutralizing IL-17A did not further reduce disease during M. pulmonis infection in BALB/c mice depleted of neutrophils, suggesting that IL-17A requires the presence of pulmonary neutrophils to worsen respiratory pathology.

  12. Caspase recruitment domain family member 14 (Card14) deficient mice display attenuated skin inflammation in the imiquimod-induced psoriasis model due to impaired Interleukin-17A (IL-17A) signaling in keratinocytes. Card14 regulates IL-17A signaling by interacting with the ACT1-TRAF6 complex.

  13. this paper shows that the increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells

  14. data thus indicates that EBV DNA itself acts as a modulator of the Th17 compartment as well as that of regulatory T cell mechanisms. The involvement of TLR9 in the EBV DNA-triggered induction of IL-17A.

  15. gammadeltaT17 cells constitutively express chemokine receptors CCR6 and CCR2

  16. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5

  17. this study shows that IL-17A negatively regulates lymphangiogenesis in T helper 17 cell-mediated inflammation

  18. The present study demonstrated that a high fat diet induces IL-17A expression, which exacerbates the progression of nonalcoholic fatty liver disease by inhibiting fatty acid beta-oxidation and promoting the accumulation of triglycerides (TG).

  19. JunB has an essential role in IL-23-dependent pathogenicity of Th17 cells

  20. Gamma-delta T cells are a prime source of protumoral IL17A in breast cancer.

Cow (Bovine) Interleukin 17A (IL17A) Interaktionspartner

  1. These results support previous gene transcription studies and extend the observation of increased IL-22 and IL-17A responses in M. bovis-infected animals to the level of protein production.

  2. calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.

  3. Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.

  4. IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.

  5. IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.

  6. The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.

Pig (Porcine) Interleukin 17A (IL17A) Interaktionspartner

  1. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.

  2. Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.

  3. conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3(+)CD4(+) and CD3(+)gammadeltaTCR(+).

  4. Cloning and expression of interleukin-17.

Rhesus Monkey Interleukin 17A (IL17A) Interaktionspartner

  1. Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

Guinea Pig Interleukin 17A (IL17A) Interaktionspartner

  1. molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.

Rabbit Interleukin 17A (IL17A) Interaktionspartner

  1. one of the interaction sites between IL17A and its receptor IL17RA

IL17A Protein Überblick

Protein Überblick

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Genbezeichner und Symbole assoziert mit Interleukin 17A Proteine (IL17A)

  • interleukin 17A (IL17A)
  • interleukin 17A (Il17a)
  • ChIL-17 Protein
  • CTLA-8 Protein
  • Ctla8 Protein
  • IL-17 Protein
  • IL-17A Protein
  • IL-17F Protein
  • Il17 Protein
  • IL17A Protein

Bezeichner auf Proteinebene für Interleukin 17A Proteine (IL17A)

CTLA-8 , cytotoxic T-lymphocyte-associated antigen 8 , cytotoxic T-lymphocyte-associated protein 8 , interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) , interleukin-17A , interleukin 17 , IL-17A , interleukin 17A , IL-17 , interleukin-17 , Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

3605 Homo sapiens
100034142 Equus caballus
16171 Mus musculus
282863 Bos taurus
395111 Gallus gallus
449530 Sus scrofa
472029 Pan troglodytes
481837 Canis lupus familiaris
708123 Macaca mulatta
301289 Rattus norvegicus
100735572 Cavia porcellus
100339322 Oryctolagus cuniculus
100860877 Capra hircus
101103931 Ovis aries
Ausgewählte Anbieter für IL17A Proteine (IL17A)
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