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The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Zusätzlich bieten wir Ihnen und IL17A Kits (118) und viele weitere Produktgruppen zu diesem Protein an.
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Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453
Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899
Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011
Our results from experiments suggest that the effects of IL-17 mediate activation of STAT3 (zeige STAT3 Proteine) signaling in breast cancer cells. Taken together, our study shows that myeloid-derived suppressor cells can be a new type of prognostic marker in breast cancer patients. Targeting IL-17/Stat3 (zeige STAT3 Proteine) signaling may be a promising strategy for BC treatment.
This study draws two main conclusions: 1) The presence of IL-17 polymorphism rs2275913 is closely related to a more severe form of the disease and as a result, a higher number of disease-modifying anti rheumatic drugs required to control it, 2) The presence of IL-17 polymorphism rs2275913 may confer a risk of developing rheumatoid arthritis in Mexican carriers
the expression of IFN-gamma (zeige IFNG Proteine) and IL-17 was also suppressed by IRAK1 (zeige IRAK1 Proteine)/4 inhibitor both in active Behcet's patients and in normal subjects.
Polymorphisms of IL-17 are associated with host susceptibility to some bacterial pathogen. [review]
secreted IL-17A is not responsible for the second hit in acute pancreatitis
In carriage, an increased IL-17 and IFN-gamma (zeige IFNG Proteine) levels were observed following stimulation with S. aureus strains.
The levels of salivary IL-6 (zeige IL6 Proteine) and IL-17 were increased significantly in calculus associated Chronic periodontitis patients.
IL17A G197A is associated with a higher susceptibility of developing OLP and these patients seem to present a considerable increase in IL17A serum levels.
These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.
Interleukin 17A (IL-17[G197G]) was associated with preterm birth (PTB (zeige PTBP1 Proteine)), and the PTB (zeige PTBP1 Proteine) group had lower IL-17A expression compared to the full-term group .
Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (zeige AOC2 Proteine)) horses.
cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
blocking activin/ACVR2A (zeige ACVR2A Proteine) impaired the potency of hepatic stellate cells to produce collagens in response to IL17s.
this study shows the positive effects of IL-17 on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro
these data suggest that IL-17A promotes DVT pathogenesis by enhancing platelet activation and aggregation, neutrophil infiltration, and EC activation
DAPK (zeige DAPK1 Proteine) deficiency leads to excess HIF-1a (zeige HIF1A Proteine) accumulation, enhanced IL-17 expression and exacerbated experimental autoimmune encephalomyelitis.
decreased COX-2 and IL-17 levels were observed in both groups treated with Nintedanib in the prostate anterior lobe. Thus, we concluded that Nintedanib was effective in delaying tumor progression and, despite not directly acting on inflammation, Nintedanib may adversely affect inflammatory pathways, favoring prostate cancer delay
In studies of mouse and human pancreatic tumors and precursors, we found that immune cell-derived IL17 regulated development of tuft cells and stem cell features of pancreatic cancer cells via increased expression of DCLK1 (zeige DCLK1 Proteine), POU2F3 (zeige POU2F3 Proteine), ALDH1A1 (zeige ALDH1A1 Proteine), and IL17RC (zeige IL17RC Proteine).
The reaction of IL-17A in the acute lung injury induced by LPS (zeige TLR4 Proteine) is stronger than that by PQ.
IL17A promoted osteoblast differentiation and calcification in a partly AKT2dependent manner in MC3T3E1 cells in vitro, possibly reflecting compensation by other signaling pathways. The results of the present study may offer novel perspectives to guide the clinical strategy for the prevention and treatment of periodontitis
Mechanistically, CREB (zeige CREB1 Proteine), activated by CD3 (zeige CD3E Proteine)-PKC- signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene locus.
These results support previous gene transcription studies and extend the observation of increased IL-22 (zeige IL22 Proteine) and IL-17A responses in M. bovis-infected animals to the level of protein production.
calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Data show that CD4 (zeige CD4 Proteine)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
IL-17A and IL-17F (zeige IL17F Proteine) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (zeige CD8A Proteine)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (zeige CD3 Proteine)(+)CD4 (zeige CD4 Proteine)(+) and CD3 (zeige CD3 Proteine)(+)gammadeltaTCR(+).
Cloning and expression of interleukin-17.
Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.
one of the interaction sites between IL17A and its receptor IL17RA (zeige IL17RA Proteine)
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
, cytotoxic T-lymphocyte-associated antigen 8
, cytotoxic T-lymphocyte-associated protein 8
, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, interleukin 17
, interleukin 17A
, Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)