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The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Zusätzlich bieten wir Ihnen IL17A Antikörper (508) und IL17A Kits (114) und viele weitere Produktgruppen zu diesem Protein an.
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Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453
Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899
Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016
In this ancillary study, baseline serum IL-17A concentration is the only Th17/IL-17 related factor that was significantly associated with the response of patients with metastatic colorectal cancer to bevacizumab. But this main significant result is highly dependent on one case which, if left out, weakens the data.
downregulation of miR (zeige MLXIP Proteine)-20a-5p is caused by promoter hypermethylation. MiR (zeige MLXIP Proteine)-20a-5p could also suppress the production of IL-17 by targeting OSM (zeige OSM Proteine) and CCL1 (zeige CCL1 Proteine) production in CD4 (zeige CD4 Proteine)(+) T cells in patients with active VKH.
No significant association between two single nucleotide polymorphisms, rs8193036 and rs2275913 in the IL17A promoter, and susceptibility to chronic viral hepatitis C and/or B and disease progression to liver cirrhosis in the Kazakh population was found.
IL17(+) neutrophils constitute a large portion of IL17-producing cells in human gastric cancer. Proinflammatory IL17 is a critical mediator of the recruitment of neutrophils into the invasive margin by CXC chemokines
The results of the present study suggest a lack of association between the rs2275913 polymorphism in the IL17A gene and the presence of HTLV-1-associated myelopathy/tropical spastic paraparesis.
The results suggest the possible involvement of the polymorphisms of IL17A G197A (rs2275913) and IL17F (zeige IL17F Proteine) T7488C (rs763780) in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy.
Data show that granulocyte-and-monocyte apheresis (GMA (zeige MAG Proteine)) successfully removed interleukin 17A (IL-17A)-producing monocytes from blood.
IL-17A acts on vessel and cardiac cells, leading to inflammation, coagulation and thrombosis. [review]
The IL-17A rs2275913 (-197G>A) polymorphism decreased the risk of post-bronchiolitis asthma at 11-13 years of age, but not earlier in life, in the present prospective, long-term follow-up study.
Our data provide the first evidence that the IL-17A rs4711998 genetic variant may contribute to HBV-related liver cirrhosis susceptibility in a Chinese population.
Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (zeige AOC2 Proteine)) horses.
cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
these data provide novel insight into a dynamic IL-17A-CXCR2 (zeige CXCR2 Proteine)-neutrophil axis during acute segmented filamentous bacteria colonization and demonstrate a central role for neutrophils in limiting segmented filamentous bacteria expansion
Transient AIEC colonization in IL-17 KO mice resulted in increased intestinal epithelial damage, systemic bacterial burden and mortality compared with controls. IL-17 is required for the induction of IL-22 (zeige IL22 Proteine) during AIEC strain E. coli LF82 colonization. IL-17 plays a protective role in AIEC strain E. coli LF82 induced colitis by promoting IL-22 (zeige IL22 Proteine) secretion.
after orthotopic lung transplantation, in the IL-17A KO group, less inflammation in the bronchovascular axis was observed and a non-significant trend towards less bronchovascular fibrosis, pleural/septal inflammation and fibrosis, and parenchymal inflammation and fibrosis when compared to WT mice
Data show that IL-17 in the serum of collagen-induced arthritis (CIA (zeige NCOA5 Proteine)) mice was markedly increased on day 14 and reached its apogee on day 27.
this study unveiled the role of IL-23 (zeige IL23A Proteine)-dependent IL-17 induction in LdCen-/- parasite-induced immunity and subsequent protection against visceral leishmaniasis
There was a significantly decreased percentage of IL-17A-producing CD4 (zeige CD4 Proteine) T cells in mice receiving Tregs from xIAP (zeige XIAP Proteine) mice. xIAP (zeige XIAP Proteine) appears dispensable for the generation of induced Treg cells as well as function of natural Treg cells. There appeared to be a role of xIAP (zeige XIAP Proteine) in generation of IL-17-producing cells from either naive CD4 (zeige CD4 Proteine) T cells or Treg cells.
astrocytic IL-17A plays important roles in the maintenance of neuropathic pain through CaMKII (zeige CAMK2G Proteine)/CREB (zeige CREB1 Proteine) signaling pathway in spinal cord.
Results reveal the importance of the IL-23 (zeige IL23A Proteine)/IL-17 inflammatory axis in secondary brain injury after intracerebral hemorrhage.
these results demonstrate an important role of CXCR6 (zeige CXCR6 Proteine) in the regulation of pathological Th17 and IL-17A(+)TCRgammadelta(+) T-cell recruitment into atherosclerotic lesions.
These results suggest that IL-17A plays an important role in host survival against Toxoplasma gondii infection by protecting the host from an anaphylactic reaction via the downregulation of Toxoplasma gondii HSP70 (zeige HSP70 Proteine) and IFN-gamma (zeige IFNG Proteine) production.
calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Data show that CD4 (zeige CD4 Proteine)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
IL-17A and IL-17F (zeige IL17F Proteine) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (zeige CD8A Proteine)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (zeige CD3 Proteine)(+)CD4 (zeige CD4 Proteine)(+) and CD3 (zeige CD3 Proteine)(+)gammadeltaTCR(+).
Cloning and expression of interleukin-17.
Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.
one of the interaction sites between IL17A and its receptor IL17RA (zeige IL17RA Proteine)
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
, cytotoxic T-lymphocyte-associated antigen 8
, cytotoxic T-lymphocyte-associated protein 8
, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, interleukin 17
, interleukin 17A
, Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)