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The protein encoded by IL17A is a proinflammatory cytokine produced by activated T cells. Zusätzlich bieten wir Ihnen IL17A Antikörper (504) und IL17A Kits (116) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 92 products:
Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453
Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899
Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016
The expression of IL-17 and IL-12 (zeige IL12A Proteine) in patients with lupus miliaris disseminatus faciei is reported in patients and healthy controls.
these findings suggest that the variants +2199 A/C IL-23R (zeige IL23R Proteine) and -197 G/A IL-17A could contribute to rheumatoid arthritis development in the studied population
IL-17A rs2275913 polymorphism did not seem to influence RA susceptibility in Tunisian population.
results suggest that IL-17A stimulated keratinocytes activated PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling and inhibited autophagy by simultaneously inhibiting autophagosome formation and enhancing autophagic flux.
In the present review, we have discussed the cellular sources, modes of action and regulation of IL-17 and IL-33 (zeige IL33 Proteine) in the context of hypersensitive diseases [Review]
Serum IL-17 and IL-23 (zeige IL23A Proteine) values positively correlated with serum total IgE levels. Serum levels of IL-10 (zeige IL10 Proteine) were lower in children with atopy and dyslipidemia than patients with dyslipidemia.
the frequencies of IFNgamma and IL-17A(+) cells were increased in the antrum, particularly in patients with H. pylori induced gastric ulcers.
Findings identify interleukin-17A as a potential mediator of neuroanatomical remodeling of the gut (zeige GUSB Proteine) innervation during inflammatory bowel diseases.
This review discusses recent discoveries related to the pro-inflammatory cytokine IL17A, and its potential role in the pathogenesis of COPD (zeige ARCN1 Proteine). We propose that an intervention strategy targeting IL-17 signaling offers an exciting opportunity to mitigate inflammatory processes, and prevent the progression of tissue pathologies associated with COPD (zeige ARCN1 Proteine) [Review]
Study shows that higher baseline levels of Interleukin 17 are selectively associated with greater symptomatic reduction in depressed patients treated with bupropion-SSRI combination.
Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (zeige AOC2 Proteine)) horses.
cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (zeige GTF2H5 Proteine) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
IL17A promoted osteoblast differentiation and calcification in a partly AKT2dependent manner in MC3T3E1 cells in vitro, possibly reflecting compensation by other signaling pathways. The results of the present study may offer novel perspectives to guide the clinical strategy for the prevention and treatment of periodontitis
Mechanistically, CREB (zeige CREB1 Proteine), activated by CD3 (zeige CD3E Proteine)-PKC- signaling, plays a key role in regulating Th17 cell differentiation, at least in part through directly binding to the Il17-Il17f gene locus.
Data show that interleukin-17 (IL-17) and fungal candidalysin amplify inflammation in a self-reinforcing feed-forward loop.
The data indicate that IL-17A contributes to augmented responses to ozone in db/db (zeige LEPR Proteine) mice. Furthermore, IL-17A appears to act at least in part by inducing expression of gastrin-releasing peptide receptor (zeige GRPR Proteine).
miR203 expression may be upregulated by IL17 stimulation, and miR203 is a positive regulator of IL17induced VEGF (zeige VEGFA Proteine) secretion.
IL-17 contributes to lung obliterative bronchiolitis pathogenesis through regulating macrophages function
we demonstrate that gammadelta T cells and CD4 (zeige CD4 Proteine)+ T (Th17) cells are the two major producers of IL-17A in the lung at the early and later stages of chlamydial infection, respectively
In mice on a C57BL/6 background, neither IL-23p19 (zeige IL23A Proteine) nor IL-17A plays a role for immune protection against L. major in the physiological context of natural infections.
IL-17A and IL-17F (zeige IL17F Proteine) exert distinct biological effects during pulmonary infection; the IL-17F (zeige IL17F Proteine)/IL-17RC (zeige IL17RC Proteine) signaling axis has the potential to significantly worsen pathogen-associated inflammation of the lower respiratory tract.
TLR2/4-mediated IL-17A inflammatory signaling is involved in vessel degeneration and revascularization, indicating that modulation of the TLR2/4-IL-17A pathway may be a novel therapeutic strategy for degenerative diseases.
These results support previous gene transcription studies and extend the observation of increased IL-22 (zeige IL22 Proteine) and IL-17A responses in M. bovis-infected animals to the level of protein production.
calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Data show that CD4 (zeige CD4 Proteine)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
IL-17A and IL-17F (zeige IL17F Proteine) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (zeige CD8A Proteine)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (zeige CD3 Proteine)(+)CD4 (zeige CD4 Proteine)(+) and CD3 (zeige CD3 Proteine)(+)gammadeltaTCR(+).
Cloning and expression of interleukin-17.
Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.
one of the interaction sites between IL17A and its receptor IL17RA (zeige IL17RA Proteine)
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
, cytotoxic T-lymphocyte-associated antigen 8
, cytotoxic T-lymphocyte-associated protein 8
, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, interleukin 17
, interleukin 17A
, Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)