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Elevated IL-17 and SOCS3 levels were identified in lupus patients. There were higher IL-17 levels in lupus nephritis (class IV) than in SLE without renal involvement.
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In conclusion, the polymorphisms of IL-17A rs2275913 and rs3819024 and the haplotype containing these two SNPs influenced the susceptibility to syphilis in a Han Chinese population.
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In a case-control study comparing overweight/obese women with women of normal weight, the IL17 AA genotype was related to the PCOS susceptibility in women of normal weight.
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IL-17A and IL-32 SNPs might be associated with predisposition to polycystic ovary syndrome in Iranian women.
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study indicates that IL-17A enhances proliferation and osteogenic differentiation of SHED by regulating OPG/RANKL mechanism thus suggests therapeutic potential of IL-17A in bone regeneration.
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These data suggest that a gene signature of IL-17 airway epithelial response distinguishes a biologically, radiographically, and clinically distinct COPD subgroup that may benefit from personalized therapy.
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rs4711998 and rs8193036 polymorphisms not associated with bronchiolitis at less than six months of age or postbronchiolitis asthma at 11-13 years of age
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Kinases SphK1 and SphK2 regulate IL-17 expression in human T cells.
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pneumococcal carriage initiates an IL-17A-mediated immune response in nasopharyngeal adenoids
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IL-17A may be a target for future CRC immunotherapy.
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PD-1(+)CD4(+) T cells with reduced proliferative capacity and increased transforming growth factor-beta (TGF-beta)/interleukin-17A (IL-17A) expression were detected in idiopathic pulmonary fibrosis.
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IL-17A-inhibited autophagy is related to Bcl2 degradation in hepatocellular carcinoma (HCC) cells. Bcl2 may be degraded via the autophagosome-lysosome pathway in HCC cells.
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this study shows that IL-6 and type-I collagen production by Systemic Sclerosis fibroblasts are differentially regulated by IL-17A in the presence of TGF-beta 1
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there was a significant difference in the serum levels of IL-6 and IL-17a between patients and controls, and the elevated levels of these two cytokines associated significantly with poor outcome in breast cancer patients and, therefore, can be used as prognostic markers.
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Opioid requirements during and after orthognathic surgery are enhanced in carriers of the AA genotype of the rs2275913 SNP of the IL-17A gene.
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This review elaborated the relationship between IFN-gamma and IL-17 in the progress of periodontitis, providing new explanations into the development of periodontitis and alveolar bone destruction caused by the host immune response [review]
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Study demonstrated that rs763780 CC functional polymorphism of IL-17A as well as IL-17 serum levels are significantly related to the risk of knee osteoarthritis susceptibility in Han Chinese population.
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IL-17 and CD40L synergistically mediate the inflammatory response and remodelling associated with tissue injury and glomerular sclerosis in diabetic nephropathy.
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IL-17A -737T/C, -444A/G, -197G/A, and -121G/A SNPs are not risk factors for rheumatoid arthritis, but the IL-17A TAGA haplotype is a risk factor for systemic lupus erythematosus.
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this study shows that IL-17A attenuates IFN-lambda expression by inducing suppressor of cytokine signaling expression in airway epithelium