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The protein encoded by IL1RL2 is a member of the interleukin 1 receptor family.
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All human blood lymphocytes express IL-36R.
The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention.
single nucleotide polymorphism A471T in the Toll (zeige TLR4 Proteine)-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP (zeige IL1RAP Proteine).
The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response.
The ubiquitin-binding Tollip (zeige TOLLIP Proteine) protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R.
IL36A (zeige IL1F6 Proteine)-IL36R axis is modulated in patients with primary Sjogren's syndrome.
Expression of IL-1Rrp2 by sone (zeige ATG9B Proteine) dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 (zeige TH1L Proteine) lymphocytes.
These data provide evidence that IL-38 (zeige IL1F10 Proteine) binds to the IL-36R, as does IL-36Ra.[IL-38 (zeige IL1F10 Proteine), IL-36R]
IL-1alpha and IL-1beta (zeige IL1B Proteine) gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry
these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis
IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality
Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS.
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
interleukin-1 receptor-like 2
, IL-1 receptor-related protein 2
, IL-36 receptor
, interleukin-1 receptor-related protein 2
, interleukin-1 receptor related protein 2