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IFNGR2 (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Zusätzlich bieten wir Ihnen IFNGR2 Antikörper (131) und IFNGR2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR (zeige LDLR Proteine) knockout mice.
A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution.
Data suggest IFNG (zeige IFNG Proteine) plays various roles in dynamics of inflammation in subjects with underlying autoimmunity modeled as "canonical" and "non-canonical" pathways; in canonical pathway, IFNG (zeige IFNG Proteine) dimerizes and binds to IFNGR1 (zeige IFNGR1 Proteine) in IFNGR1 (zeige IFNGR1 Proteine)/IFNGR2 hetero-multimer; STAT (zeige STAT1 Proteine) transcription factors are involved in non-canonical pathway. (IFNG (zeige IFNG Proteine) = interferon gamma (zeige IFNG Proteine); IFNGR (zeige IFNGR1 Proteine) = IFNG (zeige IFNG Proteine) receptor; STAT (zeige STAT1 Proteine) = signal transducers and activators of transcription)
IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) activation by IFN-gamma (zeige IFNG Proteine) could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling in patient cells, whereas adding galectins impaired these processes in control cells.
Statistical analyses revealed that four genetic variants in IFNGR1 (zeige IFNGR1 Proteine) were marginally associated with the risk of Tuberculosis (P = 0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 (zeige IFNGR1 Proteine) and IFNGR2 did not exhibit any associations
The variability of potentially important functional polymorphic variants of the IFNG (zeige IFNG Proteine), IFNGR2 and NEIL2 (zeige NEIL2 Proteine) genes was characterized in representatives of four ethnic groups living in the Siberian region.
Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency.
The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe.
We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma (zeige IFNG Proteine) receptor (IFN-gammaR (zeige IFNGR1 Proteine))2 deficiency
IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17 (zeige IL17A Proteine)(+) cells from both healthy and IFN-gammaR2-deficient CD4 (zeige CD4 Proteine)(+) T cells.
IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease.
Four SNPs in IFNGR2, IL12RB1 (zeige IL12RB1 Proteine), IL12RB2 (zeige IL12RB2 Proteine), and IL23R (zeige IL23R Proteine) were found to be associated with the MAP infection status of the resource population.
SNPs in IFNG (zeige IFNG Proteine), IFNGR1 (zeige IFNGR1 Proteine) and R2, IL22 (zeige IL22 Proteine), and IL22RA1 (zeige IL22RA1 Proteine) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
IFN-gamma receptor 2
, interferon gamma receptor 2
, interferon gamma receptor accessory factor 1
, interferon gamma receptor accessory factor-1
, interferon gamma receptor beta chain
, interferon gamma transducer 1