Interferon gamma Receptor 2 (Interferon gamma Transducer 1) Proteine (IFNGR2)

IFNGR2 (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Zusätzlich bieten wir Ihnen IFNGR2 Antikörper (95) und IFNGR2 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IFNGR2 15980  
Ratte IFNGR2 IFNGR2 360697  
IFNGR2 3460 P38484
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Human Cells Maus His tag 100 μg 14 bis 16 Tage
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
CHO Cells Human Unkonjugiert   50 μg 2 bis 3 Tage

IFNGR2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
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Weitere Proteine zu Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2) Interaktionspartnern

Mouse (Murine) Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2) Interaktionspartner

  1. Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR knockout mice.

  2. We show that demyelination in response to cuprizone is delayed in mice lacking the binding chain of IFNgamma receptor. In addition, IFNgammaR(-/-) mice exhibited an accelerated remyelination process after cuprizone was removed from the diet.

Human Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2) Interaktionspartner

  1. A purely quantitative form of partial recessive IFN-gammaR2 deficiency caused by mutations of the initiation or second codon.

  2. Successful unrelated cord blood transplant for complete IFN-gamma receptor 2 deficiency.

  3. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations

  4. The study identified an SNP rs9978223 on IFNGR2 gene, associated with increased risk in acute myocardial infarctionpatient from India.

  5. A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution.

  6. Data suggest IFNG plays various roles in dynamics of inflammation in subjects with underlying autoimmunity modeled as "canonical" and "non-canonical" pathways; in canonical pathway, IFNG dimerizes and binds to IFNGR1 in IFNGR1/IFNGR2 hetero-multimer; STAT transcription factors are involved in non-canonical pathway. (IFNG = interferon gamma; IFNGR = IFNG receptor; STAT = signal transducers and activators of transcription)

  7. The IFNGR2Q64R polymorphism is correlated with male sex and paranoid schizophrenia in Tunisians.

  8. IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK/STAT activation by IFN-gamma could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK/STAT signaling in patient cells, whereas adding galectins impaired these processes in control cells.

  9. Statistical analyses revealed that four genetic variants in IFNGR1 were marginally associated with the risk of Tuberculosis (P = 0.02-0.04), while other single nucleotide polymorphisms in IFNGR1 and IFNGR2 did not exhibit any associations

  10. The variability of potentially important functional polymorphic variants of the IFNG, IFNGR2 and NEIL2 genes was characterized in representatives of four ethnic groups living in the Siberian region.

  11. Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency.

  12. The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe.

  13. This is the first study that shows an association between SNPs and liver fibrosis in the general population

  14. It related to persistence of hepatitis B virus (HBV) infection and viral load in chronic HBV.

  15. We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma receptor (IFN-gammaR)2 deficiency

  16. IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17(+) cells from both healthy and IFN-gammaR2-deficient CD4(+) T cells.

  17. IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease.

  18. JAK2 is a critical factor that stabilizes IFN-gammaR2 surface expression in Th17 cells from AMS patients, making them sensitive to IFN-gamma.

  19. We conclude that the polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals

  20. Data indicate that perturbation of IFN-gammaR2 internalization by mutating the LI(255-256) motif induces a timely coordinated activation of IFN-gamma/STAT1 signaling pathways that leads to the apoptosis of T cells.

Cow (Bovine) Interferon gamma Receptor 2 (Interferon gamma Transducer 1) (IFNGR2) Interaktionspartner

  1. Four SNPs in IFNGR2, IL12RB1, IL12RB2, and IL23R were found to be associated with the MAP infection status of the resource population.

  2. SNPs in IFNG, IFNGR1 and R2, IL22, and IL22RA1 were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.

IFNGR2 Protein Überblick

Protein Überblick

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.

Genbezeichner und Symbole assoziert mit IFNGR2

  • interferon gamma receptor 2 (Ifngr2)
  • interferon gamma receptor 2 (IFNGR2)
  • interferon gamma receptor 2 (LOC487739)
  • AF-1 Protein
  • IFGR2 Protein
  • Ifgt Protein
  • IFNGT1 Protein

Bezeichner auf Proteinebene für IFNGR2

IFN-gamma receptor 2 , IFN-gamma-R2 , interferon gamma receptor 2 , interferon gamma receptor accessory factor 1 , interferon gamma receptor accessory factor-1 , interferon gamma receptor beta chain , interferon gamma transducer 1

15980 Mus musculus
360697 Rattus norvegicus
3460 Homo sapiens
487739 Canis lupus familiaris
514889 Bos taurus
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