Interferon Regulatory Factor 2 Proteine (IRF2)

Human Interferon Regulatory Factor 2 (IRF2) Interaktionspartner

1. This review focusses on current knowledge of the roles of IRF-1 and IRF-2 in human cancer, with particular attention paid to the impact of IRF-1 inactivation.

2. Data suggest that MIR1290 expression is remarkably upregulated in non-small-cell lung carcinoma tissues compared to adjacent normal lung tissues; IRF2 appears to be a direct target of MIR1290. (MIR1290 = microRNA-1290; IRF2 = interferon regulatory factor-2)

3. These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC.

4. Our study primarily suggests IRF-2 as a potential prognostic biomarker in colorectal cancer

5. The effects of IRF2 suppresses non-small cell lung cancer by promoting cell apoptosis, inhibiting cell proliferation and migration ability.

6. In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1. Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.

7. Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2, OCI/AML-3, and THP-1 cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (AML) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B contributes to the effects of IRF2 on apoptosis and growth of AML cells. Thus, IRF2 serves as an important regulator in AML by targeting INPP4B.

8. miR-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.

9. It might play as a tumor suppressor by regulating P53 signaling in gastric cancer.

10. the association of IRF2 with susceptibility to systemic lupus erythematosus

11. IRF2genes were not associated with pancreatitis. 4 variants were found: c.123G>A (novel), c.651C>T, c.744G>A, and c.638C>T, p.P213L.

12. Data suggest that interferon regulatory factors 1 and 2 (IRF1 and IRF2) may serve as potential targets of therapy.

13. miR-221 directly inhibits the expression of SOCS3 and IRF2.

14. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system.

15. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

16. IRF2 overexpression protects against I/R injury by decreasing IRF1-dependent injury and may represent a novel therapeutic strategy.

17. The results suggested that distinct markers in IRF2 may be associated with atopic dermatitis and eczema herpeticum (which may depend upon ethnic ancestry) and genetic variants in IRF2 may contribute to an abnormal immune response to herpes simplex virus.

18. these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.

19. IRF-2 activates the HPV-16 P97 promoter in vivo.

20. IRF-2 activates RIG-I promoter through ISRE-like site as well as IRF-1 and IFN-alpha stimulation.

Mouse (Murine) Interferon Regulatory Factor 2 (IRF2) Interaktionspartner

1. Data show that HCFC2 is a critical component of the IRF1 and IRF2 transcriptional machinery that regulates Tlr3 gene expression.

2. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.

3. Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion

4. Chimeric IRF-2 binds with IRF-E motif and VREbeta but not with VREalpha1.

5. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system.

6. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

7. These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR-dependent manner and antibody production via up-regulation of Blimp-1.

8. In mice doubly deficient forIRF-2 and CD1d, the overall memory phenotype T cell population is contrastingly enlarged.

9. IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.

10. Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.

11. Irf2 has an important role in vitro in the regulation of COX-2 expression by LPS.

12. IRF-2 is acetylated in a cell growth-dependent manner, which enables it to contribute to transcription of cell growth-regulated promoters

13. IRF-2 is a critical transacting factor that regulates in vivo responses to lipopolysaccharide, with a novel anti-apoptotic role.

14. In the absence of IRF-2, uterine natural killer (uNK) cells are normal in number and function, but there is a serious deficiency of peripheral NK cells.

15. IFN regulatory factor 2 is involved in the negative regulation of IFN-alpha/beta signaling.

16. Binding affinity of IRF-2 is similar to that of IRF-1 and B lymphocyte-induced maturation protein-1 (Blimp-1) for functionally important regulatory sites containing the consensus sequence GAAAG.

17. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation

18. Differential peripheral and central natural killer (NK) cell deficiencies in IRF-2 knockout mice reveal a novel late checkpoint for NK cell maturation, distinct from the early IL-15-dependent expansion stage.

19. the negative regulatory role of IRF-2 on the basophil population size is critically important for preventing excess Th2 polarization and the Th1/Th2 balance in naive animals

20. Together, these data demonstrate that IRF-2 is involved in the regulation of TR2 expression in EL-4 T cells.