Interferon Regulatory Factor 2 Proteine (IRF2)

Human Interferon Regulatory Factor 2 (IRF2) Interaktionspartner

1. Data suggest that MIR1290 expression is remarkably upregulated in non-small-cell lung carcinoma tissues compared to adjacent normal lung tissues; IRF2 appears to be a direct target of MIR1290. (MIR1290 = microRNA-1290; IRF2 = interferon regulatory factor-2)

2. These finding suggests that miR (zeige MLXIP Proteine)-302b inhibits key transcription factors and cytokines by targeting ERBB4 (zeige ERBB4 Proteine), IRF2 and CXCR4 (zeige CXCR4 Proteine), implicating its role in the inhibition of CRI in EC.

3. Our study primarily suggests IRF-2 as a potential prognostic biomarker in colorectal cancer

4. The effects of IRF2 suppresses non-small cell lung cancer by promoting cell apoptosis, inhibiting cell proliferation and migration ability.

5. In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1 (zeige APOL1 Proteine). Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection.

6. Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2 (zeige RUNX3 Proteine), OCI/AML-3 (zeige RUNX2 Proteine), and THP-1 cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B (zeige INPP4B Proteine) contributes to the effects of IRF2 on apoptosis and growth of AML (zeige RUNX1 Proteine) cells. Thus, IRF2 serves as an important regulator in AML (zeige RUNX1 Proteine) by targeting INPP4B (zeige INPP4B Proteine).

7. miR (zeige MLXIP Proteine)-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion.

8. It might play as a tumor suppressor by regulating P53 (zeige TP53 Proteine) signaling in gastric cancer.

9. the association of IRF2 with susceptibility to systemic lupus erythematosus

10. Data suggest that interferon (zeige IFNA Proteine) regulatory factors 1 and 2 (IRF1 (zeige IRF1 Proteine) and IRF2) may serve as potential targets of therapy.

Mouse (Murine) Interferon Regulatory Factor 2 (IRF2) Interaktionspartner

1. Data show that HCFC2 (zeige HCFC2 Proteine) is a critical component of the IRF1 (zeige IRF1 Proteine) and IRF2 transcriptional machinery that regulates Tlr3 (zeige TLR3 Proteine) gene expression.

2. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.

3. Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion

4. Chimeric IRF-2 binds with IRF (zeige TRIM63 Proteine)-E motif and VREbeta but not with VREalpha1.

5. KGF (zeige FGF7 Proteine) could up-regulate IL-7 (zeige IL7 Proteine) expression through the STAT1 (zeige STAT1 Proteine)/IRF-1 (zeige IRF1 Proteine), IRF-2 signaling pathway, which is a new insight in potential effects of KGF (zeige FGF7 Proteine) on the intestinal mucosal immune system.

6. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3

7. These results revealed a multi-faceted role of IRF-2 in the function of B cells, particularly B2 cells, through regulating proliferation in an IFNAR (zeige IFNAR1 Proteine)-dependent manner and antibody production via up-regulation of Blimp-1 (zeige PRDM1 Proteine).

8. In mice doubly deficient forIRF-2 and CD1d (zeige CD1D Proteine), the overall memory phenotype T cell population is contrastingly enlarged.

9. IRF2 regulates exocytosis in pancreatic acinar cells; defects in this process might be involved in the early phases of acute pancreatitis.

10. Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells.