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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Zusätzlich bieten wir Ihnen Integral Membrane Protein 2B Proteine (19) und Integral Membrane Protein 2B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 62 products:
Human Polyclonal ITM2B Primary Antibody für ELISA, WB - ABIN451809
Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008
Human Polyclonal ITM2B Primary Antibody für ICC, IF - ABIN4327783
Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015
ITM2B is expressed in most cortical neurons, neurons of the hippocampus and dentate nucleus, cerebellar Purkinje and granule cells, and (newly described here) in focal neurons in the basal ganglia, many neurons of the thalamus and brainstem, many cells in the ependyma and choroid plexus, and in the smooth muscle of blood vessels. ITM2B expression is prominent in plaques in AD-containing dystrophic neurites
by modulating BRI2 processing using an ADAM10 (zeige ADAM10 Antikörper) inhibitor, a dual role for BRI2 in neurite outgrowth is suggested: phosphorylated full-length BRI2 appears to be important for the formation of neuritic processes, and BRI2 NTF (zeige RHBDL2 Antikörper) promotes neurite elongation.
Familial British dementia (FBD) and familial Danish dementia (FDD) are caused by mutations in the BRI2 gene.
when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.
Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.
Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (zeige BCL6 Antikörper) protein (BCL6 (zeige BCL6 Antikörper)) repression in lymphoma.
Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.
This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.
It binds amyloid precursor protein (zeige APP Antikörper) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (zeige SYP Antikörper) levels.
BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (zeige IDE Antikörper)).
Suggest that Adam7 (zeige ADAM7 Antikörper) functions in fertilization through the formation of a complex with heat shock protein 5 (zeige HSPA5 Antikörper), calnexin (zeige CANX Antikörper) and Itm2b during capacitation in sperm.
The shor form of ITM2B induces apoptosis in IL-2 (zeige IL2 Antikörper)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (zeige BCL2 Antikörper), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.
ITM2B(S) induces apoptosis via a caspase (zeige CASP3 Antikörper)-dependent mitochondrial pathway.
BH3-only (zeige BBC3 Antikörper) protein ITM2Bs is able to induce apoptotic cell death in p53 (zeige TP53 Antikörper)+/+, as well as in p53 (zeige TP53 Antikörper)-/- cell lines.
Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
ABri/ADan amyloid peptide
, BRICHOS domain containing 2B
, immature BRI2
, transmembrane protein BRI
, Integral membrane protein 2B (E25B protein)
, integral membrane protein 2B
, putative transmembrane protein E3-16
, transmembrane protein E3-16
, BRICHOS-like protein
, integral membrane protein 2b