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The protein encoded by INPP5A is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.
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The ataxic phenotype and characteristics neurodegeneration of the Inpp5a Gt(OST50073)Lex (zeige FUT4 Proteine) mouse indicate a crucial role for Inpp5a in purkinje cells survival.
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
43 kDa inositol polyphosphate 5-phophatase
, CTCL tumor antigen HD-CL-02
, InsP3 5-phosphatase
, inositol trisphosphate-5-phosphatase, 40kD
, type I inositol 1,4,5-trisphosphate 5-phosphatase
, type I inositol-1,4,5-trisphosphate 5-phophatase
, type I inositol-1,4,5-trisphosphate 5-phosphatase
, inositol-1,4,5-trisphosphate 5-phosphatase