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ITPA encodes an inosine triphosphate pyrophosphohydrolase. Zusätzlich bieten wir Ihnen Inosine Triphosphatase Proteine (24) und Inosine Triphosphatase Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal ITPA Primary Antibody für ELISA - ABIN517268
Vroemen, Munnix, Bakker, Bierau, Huts, Leers: A novel multiparameter flow cytometric assay for inosine triphosphatase expression analysis in leukocytes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2012
The authors analysed ITPA-deficient human and mouse cells, and revealed that ITPA deficiency induces MLH1 (zeige MLH1 Antikörper)/PMS2 (zeige PMS2 Antikörper)- and p53 (zeige TP53 Antikörper)-dependent growth arrest and DNA instability in mammalian cells.
In the mouse genome, we found one processed Itpa gene-like sequence and two processed Itpa pseudogenes as well as the Itpa gene itself with introns.
The role of ITPase in mice is to exclude ITP from the ATP pool, and the main target substrate of this enzyme is rITP
Inosine triphosphate pyrophosphatase dephosphorylates ribavirin triphosphate, and reduced enzymatic activity potentiates mutagenesis in hepatitis C virus.
This study suggests that the polymorphisms in the ITPA gene influence the severity of anaemia during the first month of a DAA/RBV-based treatment in HCV-related cirrhosis.
baseline testing of this single ITPA SNP might help to identify the subset of patients with the greatest risk for experiencing RBV-induced anaemia, which may be particularly helpful in those with underlying cardiovascular disease. In such patients, RBV-sparing regimens should be preferred.
ITPA variant rs1127354C>A significantly predict RBV-induced anaemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration
The ITPA gene polymorphism rs1127354 heterozygous genotype (CA) may influence Hemoglobin levels and protect against hemolytic anemia during ribavirin containing regimens for hepatitis C
Four gene signature (PTEN, PIK3C2A (zeige PIK3C2A Antikörper), ITPA and BCL3 (zeige BCL3 Antikörper)) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma (zeige MOK Antikörper).
Inosine triphosphatase polymorphism appeared to correlate with anemia in- cidence and RBV dose reduction during SOF (zeige GJA1 Antikörper)/RBV therapy.
Inosine triphosphatase (IPTA) rs1127354 variants but not rs7270101 were found in Chinese patients infected with chronic hepatitis C. IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the virological response to pegylated interferon plus ribavirin combination therapy in Chinese chronic hepatitis C virus-infected patients.
This study concluded that HIV-infection seems to be interfering with the nucleotide metabolism in leukocytes, including CD4 (zeige CD4 Antikörper) lymphocytes, by decreasing ITPase expression, independently of ITPA genotype.
This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants.
inosine triphosphate pyrophosphatase
, inosine triphosphatase
, non-canonical purine NTP pyrophosphatase
, non-standard purine NTP pyrophosphatase
, nucleoside triphosphate pyrophosphatase
, nucleoside-triphosphate diphosphatase
, nucleoside-triphosphate pyrophosphatase
, inosine triphosphatase-A
, inosine triphosphate pyrophosphohydrolase
, putative oncogene protein HLC14-06-P
, inosine triphosphatase A
, Inosine triphosphatase
, Non-canonical purine NTP pyrophosphatase
, Non-standard purine NTP pyrophosphatase
, Nucleoside-triphosphate diphosphatase
, Nucleoside-triphosphate pyrophosphatase
, hypothetical protein