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ING4 encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling.
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Inhibitor of growth (zeige ING1 ELISA Kits) 4 upregulation plus radiotherapy induced synergistic tumor suppression in SPC (zeige UCN3 ELISA Kits)-A1 xenografts implanted in athymic nude mice. Thus, the restoration of inhibitor of growth (zeige ING1 ELISA Kits) 4 function might provide a potential strategy for non-small cell lung cancer radiosensitization.
Results found that ING4 expression was significantly reduced in CRC (zeige CALR ELISA Kits) tissues and associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Also, ING4 suppressed CRC (zeige CALR ELISA Kits) angiogenesis by inhibition of Sp1 (zeige PSG1 ELISA Kits) expression and transcriptional activity through destabilization and ubiquitin degradation and down-regulation of Sp1 (zeige PSG1 ELISA Kits) downstream pro-angiogenic factors MMP-2 (zeige MMP2 ELISA Kits) and COX-2 (zeige COX2 ELISA Kits).
Low ING4 expression is associated with malignant phenotype and temozolomide chemoresistance in glioblastomas.
ING4 directly binds the Miz1 promoter and is required to induce Miz1 mRNA and protein expression during luminal cell differentiation.
The oncogenic role of miR (zeige MLXIP ELISA Kits)-330 in Hepatocellular Carcinoma Cells is linked to downregulation of ING4.
ING4 binds double-stranded DNA through its central region with micromolar affinity.
results indicate that the combination of ING4 and PTEN may provide an effective therapeutic strategy for HCC
ING4 can facilitate cancer cell sensitivity to chemotherapy and radiotherapy. Although ING4 loss is observed for many types of cancers, increasing evidences show that ING4 can be used for gene therapy. In this review, the recent progress of ING4 regulating tumorigenesis is discussed
ING4 inhibits CRC (zeige CALR ELISA Kits) invasion and metastasis probably via a switch from mesenchymal marker N-cadherin (zeige CDH2 ELISA Kits) to epithelial marker E-cadherin (zeige CDH1 ELISA Kits) through downregulation of Snail1 (zeige SNAI1 ELISA Kits) epithelial-mesenchymal transition (EMT (zeige ITK ELISA Kits))-inducing transcription factor (EMT (zeige ITK ELISA Kits)-TF).
Data show that Ras protein regulates inhibitor of growth protein 4 (ING4)-thymine-DNA glycosylase (TDG (zeige TDG ELISA Kits))-Fas (zeige FAS ELISA Kits) protein axis to promote apoptosis resistance in pancreatic cancer.
IL-6 (zeige IL6 ELISA Kits) Receptor is overexpressed in glioma, and it can be used for targeted delivery of the therapeutic ING4 to the tumor.
ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (zeige FAS ELISA Kits)-induced apoptosis in a caspase-8 (zeige CASP8 ELISA Kits)-dependent pathway.
Inhibitor of growth (zeige ING1 ELISA Kits)-4 promotes IkappaB promoter activation to suppress NF-kappaB (zeige NFKB1 ELISA Kits) signaling and innate immunity
Report down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins.
inhibitor of growth protein 4
, inhibitor of growth family, member 4
, brain my036 protein
, candidate tumor suppressor p33 ING1 homolog
, ING1-like protein