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ID4 encodes a member of the inhibitor of DNA binding (ID) protein family. Zusätzlich bieten wir Ihnen ID4 Antikörper (79) und ID4 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
results indicate that Id4 marks spermatogonial stem cells in the mouse testis.
ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation.
Id4 regulates NKX3.1, Sox9 and PTEN.
Id4 is a novel regulator of estrogen signaling, where Id4 restrains ERalpha (zeige ESR1 ELISA Kits) expression in the basal and luminal cellular compartments of the mammary gland and regulates estrogen biosynthesis in the ovary
High expression levels of Id1 (zeige ID1 ELISA Kits)-4 proteins may play important roles in regulating retinal progenitor cell proliferation and differentiation.
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
ID4 promotes mammary gland development by suppressing p38MAPK (zeige MAPK14 ELISA Kits) activity.
Study confirms the importance of the silencing of ID4 in murine and human CLL pathogenesis.
Id4 was identified as a key transcription factors enriched in the early phase of differentiation and affecting the differentiation of both osteoblasts and adipocyte cell types.
id4 appears to control the number of endocardial cells that contribute to the AV valves by regulating Wnt (zeige WNT2 ELISA Kits) signaling in the developing AVC endocardium
Study demonstrates that ID4, can promote p53 (zeige TP53 ELISA Kits)- dependent apoptosis and senescence in prostate cancer cells by specifically modifying the acetylation of p53 (zeige TP53 ELISA Kits), which increases its transcriptional activity and promotes the expression of pro-apoptotic and cell cycle regulatory genes.
The cellular uptake of inhibitor of DNA binding 4 protein (ID4) resulted in increased apoptosis, decreased proliferation and colony formation.
Several lines of evidence suggest ID4 may suppress BRCA1 function in basal-like breast cancer (BLBC) and in doing so, define a subset of BLBC patients who may respond to therapies traditionally used in BRCA1-mutant cancers. This review highlights recent advances in our understanding of the requirement for ID4 in mammary lineage commitment and the role for ID4 in BLBC.
The expression of Id4 protein was up-regulated in tumor tissues from hepatocellular carcinoma (HCC) patients, and overexpression of Id4 promoted HCC cell proliferation, clonogenicity in vitro, and tumorigenicity in vivo.
ID4 selectively regulates AR activity through direct interaction with FKBP52 (zeige FKBP4 ELISA Kits).
High ID4 expression is associated with basal breast cancer.
A cell-autonomous positive-signaling circuit is associated with the PDGFB (zeige PDGFB ELISA Kits)-NO-ID4-regulatory axis in glioblastoma cells.
ID4 expression induces AR expression in PC3 (zeige PCSK1 ELISA Kits) cells, which generally lack AR. ID4 expression increased apoptosis and decreased cell proliferation and invasion.
CEACAM1 (zeige CEACAM1 ELISA Kits) is able to maintain the active transcription of ID4 by an epigenetic mechanism involving HDAC4 (zeige HDAC4 ELISA Kits) and CaMK2D (zeige CAMK2D ELISA Kits), and the same kinase enables lumen formation by CEACAM1 (zeige CEACAM1 ELISA Kits)
In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (zeige NR4A2 ELISA Kits))early growth response (EGR)2 (zeige EGR2 ELISA Kits) and NR4A2EGR3. Therefore, RUNX1 (zeige RUNX1 ELISA Kits), NR4A2 (zeige NR4A2 ELISA Kits), EGR2 (zeige EGR2 ELISA Kits), EGR3 (zeige EGR3 ELISA Kits) and ID4 may be key genes associated with the pathogenesis of DS.
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner.
DNA-binding protein inhibitor ID-4
, inhibitor of DNA binding 4 a
, class B basic helix-loop-helix protein 27