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HPGD encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. Zusätzlich bieten wir Ihnen HPGD Kits (17) und HPGD Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HPGD Primary Antibody für ICC, IF - ABIN152315
Giannoulias, Patel, Holloway, Lye, Tai, Challis: Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium. in The Journal of clinical endocrinology and metabolism 2002
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Human Polyclonal HPGD Primary Antibody für IHC, IHC (p) - ABIN4319762
Wu, Hsu, Chen, Yu, Chang, Tai, Liu, Su, Chang, Yu: Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. in Molecular & cellular proteomics : MCP 2010
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Human Polyclonal HPGD Primary Antibody für IHC (p), IHC - ABIN250327
Coggins, Latour, Nguyen, Audoly, Coffman, Koller: Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. in Nature medicine 2002
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Human Polyclonal HPGD Primary Antibody für IF (p), IHC (p) - ABIN761711
Wei, Yu, Shi, Zhang, Lian, Li, Shen, Xing, Zhu: 15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway. in Cellular signalling 2014
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Human Polyclonal HPGD Primary Antibody für WB - ABIN516675
Hughes, Otani, Yang, Newman, Yantiss, Altorki, Port, Yan, Markowitz, Mazumdar, Tai, Subbaramaiah, Dannenberg: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. in Cancer prevention research (Philadelphia, Pa.) 2009
15-PGDH prevents lipopolysaccharide-induced acute liver injury in mice.
the protein level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin metabolism, in Amyotrophic lateral sclerosis model mice at three different disease stages, was investigated.
15-PGDH is downregulated in human hepatoma cells with a high COX-2 (zeige COX2 Antikörper) expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) and in human HCC (zeige FAM126A Antikörper) biopsies.
Data from a mouse model suggest that expression of Hpgd protein in uterus is down-regulated in lipopolysaccharide/infection-induced embryo loss.
prostaglandin E synthase (zeige PTGES Antikörper) (cPGES/p23 (zeige PTGES3 Antikörper)) acts as a regulatory factor for expression of a prostaglandin E2 -inactivating enzyme,15-hydroxyprostaglandin dehydrogenase ( 15-PGDH).
I. sinclarii is effective in lowering blood glucose due to the upregulation of glucokinase (Gk (zeige GCK Antikörper)-rs1 (zeige RS1 Antikörper)) and downregulation of hydroxyprostaglandin dehydrogenase.
OAT (zeige OAT Antikörper)-PG is proposed to be involved in the local PGE (zeige LIPF Antikörper)(2) clearance and metabolism for the inactivation of prostaglandin signals in the kidney cortex.
novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression
15-Hydroxyprostaglandin dehydrogenase (zeige CBR1 Antikörper) has a role in suppressing colon tumorigenesis
The intrarenal distribution of 15-PGDH and its interactions with COX-2 (zeige COX2 Antikörper) suggest that differential regulation of COX-2 (zeige COX2 Antikörper) and 15-PGDH plays a role in determining levels of prostaglandins involved in regulation of salt, volume, and blood pressure homeostasis.
Data indicate that 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor TD88 could be a good effector on wound healing, especially in the aspects of prevention of scarring.
The data indicate that decreased expression of 15-hydroxyprostaglandin dehydrogenase in the fetal membranes may contribute to the increase in intrauterine prostaglandin concentrations at term, stimulating the onset of labor.
Results found that low 15-PGDH expression was significantly associated with advanced tumors, presence of lymph node metastasis and invasion, and poor prognosis in pancreatic ductal adenocarcinoma patients.
The reduced 15-PGDH may result in PGE2 accumulation which sustains carcinogenesis and tumor progression. We further found that miR (zeige MLXIP Antikörper)-21 exert its oncogenic role through PGE2/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) axis in gastric cell proliferation. In conclusion, our findings enlarged our knowledge in the roles of miR (zeige MLXIP Antikörper)-21 in the progression of gastric cancer.
WNT5A (zeige WNT5A Antikörper) signaling regulates 15-PGDH expression.
miR (zeige MLXIP Antikörper)-21-HPGD regulatory module may play an important role as part of a feed-forward loop that regulates the PGE2 signaling. Such a feed-forward regulatory mechanism likely plays a critical role in OTSCC initiation and progression.
inhibitory effects of 17-AAG (zeige MPG Antikörper) on PGE2 levels in HT-29 colorectal cancer cells were mediated through modulating COX-2 (zeige COX2 Antikörper) and 15-PGDH expression.
A common mutation and a novel mutation in HPGD gene were identified to be responsible for primary hypertrophic osteoarthropathy
Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.
Neoadjuvant chemotherapy could increase 15-PGDH expression in advanced gastric cancer patients, and 15-PGDH may serve as a candidate prognostic biomarker of advanced GC response to therapy.
15-PGDH mRNA levels were significantly higher in aorta samples from patients undergoing abdominal aortic aneurysm repair than in those from healthy multiorgan donors.
Omega-3 polyunsaturated fatty acids upregulate the expression of 15-PGDH by inhibiting miR (zeige MLXIP Antikörper)-26a and miR (zeige MLXIP Antikörper)-26b.
HPGD may play a role during establishment and termination of gestation
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
, hydroxyprostaglandin dehydrogenase 15-(NAD)
, 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
, prostaglandin dehydrogenase 1
, NAD-dependent 15-hydroxyprostaglandin dehydrogenase
, 15-hydroxyprostaglandin dehydrogenase (NAD+)
, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
, short chain dehydrogenase/reductase family 36C, member 1
, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase