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HOXC8 belongs to the homeobox family of genes. Zusätzlich bieten wir Ihnen Homeobox C8 Antikörper (73) und und viele weitere Produktgruppen zu diesem Protein an.
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Results show that HOXC8 is consistently downregulated in stem/progenitor cells of all breast molecular subtypes, thus representing a putative tumor suppressor candidate. Also, downregulated expression of HOXC8 is associated with DNA methylation (zeige HELLS Proteine) at the gene promoter and expression of miR196 family members. Taken together, study establishes HOXC8 as a suppressor of stemness and transformation in the mammary gland lineage.
Owing to the overexpression of Homeobox C8 (HOXC8), findings implied that HOXC8 is involved in the progression of epithelial ovarian cancer (EOC) and could be a potential therapeutical approach of EOC.
High expression of HOXC8 is associated with laryngeal squamous cell carcinoma.
HOXC8 knockdown led to inhibition of tumor cell proliferation and migration in vitro by inhibiting MMP-9 (zeige MMP9 Proteine) expression and tumor growth in vivo. The results strongly suggest that HOXC8 is involved in the tumorigenesis of osteosarcoma and might serve as a novel predictor for patients' outcome.
embigin (zeige EMB Proteine) is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors
Ectopic expression of HoxC8 inhibits nasopharyngeal carcinoma cell growth in vitro and in vivo, modulates glycolysis and regulates the expression of tricarboxylic acid (TCA) cycle-related genes.
Upregulated HOXC8 expression was associated with oxaliplatin resistance in hepatocellular carcinoma.
miR (zeige MLXIP Proteine)-196a was over-expressed in cervical cancer cells, while an absence of HOXC8 expression was observed.
HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.
HOXC8 can be used as a prognostic marker in esophageal squamous cell carcinoma
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (zeige HOXA1 Proteine), HoxA5 (zeige HOXA5 Proteine), HoxC4 (zeige HOXC4 Proteine) &HoxC8 markedly enhanced. Irrespective of presence or absence of T3, insulin (zeige INS Proteine) down regulates HoxA10 (zeige HOXA10 Proteine). T3 results in over expression of HoxA5 (zeige HOXA5 Proteine), HoxC4 (zeige HOXC4 Proteine) and HoxC8 genes, whereas insulin (zeige INS Proteine) up regulates expression of only HoxC8
Hoxc8 initiates an ectopic mammary program by regulating Fgf10 (zeige FGF10 Proteine) and Tbx3 (zeige TBX3 Proteine) expression and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling
Cdx1 (zeige CDX1 Proteine) regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
Hoxc8 downregulates Mgl1 (zeige LLGL1 Proteine) tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4 (zeige HOXD4 Proteine)-transgenic mice.
Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 (zeige SMAD6 Proteine) promoter activity and its mRNA expression
Hoxc8 regulation is essential for osteoblast differentiation.
Pcna (zeige PCNA Proteine) is a direct downstream target of Hoxc8.
interaction with smad1 (zeige SMAD1 Proteine) stimulates bone development
remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity
Cdx1 (zeige CDX1 Proteine) binds directly these responsive elements during embryogenesis, as part of the mechanism for the timely activation of HoxC8 expression.
Remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.
Hox-3.1, mouse, homolog of
, homeo box 3A
, homeo box C8
, homeobox protein Hox-3A
, homeobox protein Hox-C8
, homeobox protein Hox-3.1
, homeobox protein M31
, homeobox C8
, Homeobox gene C8
, homeobox protein R4
, homeobox protein pXhoxc8
, homeobox c8a
, homeobox gene C-8
, homeobox protein Hox-C8a
, Homeobox protein Hox-C8a
, homeobox protein HOXC-8
, homeobox protein HoxC8a
, LOW QUALITY PROTEIN: homeobox protein Hox-C8