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HRC encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. Zusätzlich bieten wir Ihnen HRC Kits (4) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HRC Primary Antibody für IHC, IHC (p) - ABIN4319846
Boncompagni, Thomas, Lopez, Allen, Yuan, Kranias, Franzini-Armstrong, Perez: Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis. in PLoS ONE 2012
The minimal KEKE motif of TRN (zeige TNPO1 Antikörper) involved in the interactions with CSQ2, HRC and RyR2 (zeige RYR2 Antikörper) within the Ca2 (zeige CA2 Antikörper)+ release units of cardiac sarcoplasmic reticulum has been defined.
While CASQ2 (zeige CASQ2 Antikörper) stabilizes RyR2 (zeige RYR2 Antikörper) rendering it refractory in the diastolic phase, HRC enhances RyR2 (zeige RYR2 Antikörper) activity facilitating RyR2 (zeige RYR2 Antikörper) recovery from refractoriness.
Ablation of HRC is associated with poorly regulated SR Ca(2 (zeige CA2 Antikörper)+)-cycling, and severe pathology under pressure-overload stress, suggesting an essential role of HRC in maintaining the integrity of cardiac function.
Results identify the HRC enhancer as the first MEF2 (zeige MEF2C Antikörper)-dependent, CArG-motif-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of a sarcoplasmic reticulum gene in vivo.
alterations in expression levels of HRC are associated with impaired cardiac SR Ca homeostasis and contractile function.
HRC may be an integral regulatory protein involved in cardiac muscle SR Ca uptake and Ca homeostasis
The exaggerated response of HRC knockout mice to the induction of cardiac hypertrophy is consistent with a regulatory role for HRC in calcium handling in vivo.
Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 (zeige ATP2A2 Antikörper) and triadin (zeige TRDN Antikörper), mediating a fine cross talk between SR Ca uptake and release in the heart.
this study demonstrates a role of HRC in promoting hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) growth, besides its role in inducing HCC (zeige FAM126A Antikörper) metastasis, and highlights HRC as a promising intervention target for HCC (zeige FAM126A Antikörper).
Up-regulation of histidine-rich calcium binding protein promotes tumor metastasis in hepatocellular carcinoma and is mediated by SATB1 (zeige SATB1 Antikörper).
The S96A HRC mutation disrupts the Ca2 (zeige CA2 Antikörper)+ -microdomain around the RyR2 (zeige RYR2 Antikörper), as it alters the Ca2 (zeige CA2 Antikörper)+ -dependent association of RyR2 (zeige RYR2 Antikörper) and HRC.
findings suggest that aberrant sarcoplasmic reticulum Ca2 (zeige CA2 Antikörper)+ release and increased susceptibility to delayed afterdepolarizations underlie triggered arrhythmic activity in Ala96 HRC carriers
Results identify the HRC enhancer as the first MEF2 (zeige MEF2A Antikörper)-dependent, CArG-motif-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of a sarcoplasmic reticulum gene in vivo.
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR.
histidine rich calcium binding protein
, histidine-rich calcium-binding protein
, sarcoplasmic reticulum histidine-rich calcium-binding protein
, histidine rich calcium-binding protein