Hippocalcin Proteine (HPCA)

The protein encoded by HPCA is a member of neuron-specific calcium-binding proteins family found in the retina and brain. Zusätzlich bieten wir Ihnen Hippocalcin Antikörper (49) und Hippocalcin Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HPCA 3208 P84074
HPCA 15444 P84075
HPCA 29177 P84076
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Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag 100 μg 15 bis 18 Tage
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human HPCA Protein. 100 μg 11 bis 18 Tage
Hefe Ratte His tag   1 mg 60 bis 71 Tage
Hefe Rind (Kuh) His tag   1 mg 60 bis 71 Tage

HPCA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Hippocalcin (HPCA) Interaktionspartnern

Human Hippocalcin (HPCA) Interaktionspartner

  1. Sequence analysis of the HPCA gene in 505 patients with dystonia did not reveal variants in the coding regions of HPCA.

  2. hippocalcin forms oligomers upon calcium binding and directly interacts with VGCCs. The dystonia-causing mutations did not affect protein stability or folding. In common for both T71N and A190T mutants was an impaired calcium-dependent oligomerisation and increased intracellular calcium influx after KCl depolarisation.

  3. None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence.

  4. Mutations in HPCA cause autosomal-recessive primary isolated dystonia.

  5. analysis of a novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents

  6. Hippocalcin is a sensitive Ca2+ sensor capable of responding to increases in intracellular Ca2+ concentration over the narrow dynamic range of 200-800 nM free Ca2+.

  7. The structural factors affecting the binding of hippocalcin to phosphatidylinositol 4,5-bisphosphate at the cell surface and the Golgi apparatus are described.

  8. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons.

  9. diminished hippocalcin expression does not contribute to Huntington disease-related neurodegeneration

Mouse (Murine) Hippocalcin (HPCA) Interaktionspartner

  1. results suggest that 7,8-Dihydroxy-4-methylcoumarin prevents glutamate-induced toxicity by scavenging free radicals and regulating hippocalcin expression.

  2. Hippocalcin and KCNQ channels contribute to the kinetics of the slow afterhyperpolarization

  3. Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.

  4. An age-dependent increase in neurodegeneration occurred in the gene-deleted mice, showing that hippocalcin contributes to neuronal viability during aging.

  5. These results suggest that hippocalcin plays a crucial role in the Ca(2+)-signaling pathway that underlies long-lasting neural plasticity and that leads to spatial and associative memory.

  6. These results suggest that hippocalcin plays an important role in calcium extrusion from neurons and, in turn, helps to protect them against calcium-dependent excitotoxin damage in the hippocampus.

Cow (Bovine) Hippocalcin (HPCA) Interaktionspartner

  1. hippocalcin-modulated ONE-GC transduction system exists in the olfactory receptor neuroepithelium. The Hpca-gene knock out studies demonstrate that the portion of this is about 30% of the total membrane guanylate cyclase transduction system

Hippocalcin (HPCA) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species.

Genbezeichner und Symbole assoziert mit Hippocalcin Proteine (HPCA)

  • hippocalcin (hpca)
  • hippocalcin S homeolog (hpca.S)
  • hippocalcin (HPCA)
  • hippocalcin (Hpca)
  • BDR2 Protein
  • MGC80408 Protein
  • MGC84992 Protein
  • zgc:73126 Protein

Bezeichner auf Proteinebene für Hippocalcin Proteine (HPCA)

neuron-specific calcium-binding protein hippocalcin , hippocalcin , calcium-binding protein BDR-2 , neuron specific calcium-binding protein hippocalcin , P23K , calcium-binding protein

393696 Danio rerio
446775 Xenopus laevis
733559 Xenopus (Silurana) tropicalis
746988 Pan troglodytes
3208 Homo sapiens
15444 Mus musculus
29177 Rattus norvegicus
509772 Bos taurus
100144505 Sus scrofa
419668 Gallus gallus
611787 Canis lupus familiaris
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