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Hepatitis A Virus P3C Proteine

Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome.

3 Treffer:

Hepatitis A Virus P3C (HAV P3C) Protein Protein

HAV P3C Spezies: Hepatitis A Virus (HAV) Quelle: Escherichia coli (E. coli) Recombinant EIA, WB
Produktnummer ABIN573611
$1,163.07
Zzgl. Versandkosten $45.00
1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen

Hepatitis A Virus P3C (HAV P3C) Protein Protein

HAV P3C Spezies: Hepatitis A Virus (HAV) Recombinant
Produktnummer ABIN1063932
$317.04
Zzgl. Versandkosten $45.00
100 μg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 Werktagen

Hepatitis A Virus P3C (HAV P3C) Protein Protein

HAV P3C Spezies: Hepatitis A Virus (HAV) Recombinant
Produktnummer ABIN622213
$1,351.90
Zzgl. Versandkosten $45.00
1 mg (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 bis 8 Werktagen
  • Typ Protein
    • Protein
  • Target Hepatitis A Virus P3C (HAV P3C)
    • Hepatitis A Virus P3C (HAV P3C)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Thymidylate Kinase (Tmk)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Growth Hormone 1 (GH1)
    • Lipoyl synthase lipA
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Leptin (LEP)
    • Epidermal Growth Factor (EGF)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Interleukin 8 (IL8)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • Hemoglobin, alpha 1 (HBA1)
    • Interleukin 1 alpha (IL1A)
    • phosphatidylserine Decarboxylase (PISD)
    • Prolactin (PRL)
    • Albumin (ALB)
    • Interleukin 13 (IL13)
    • Streptavidin
    • CD40 Ligand (CD40LG)
    • Interleukin 15 (IL15)
    • beta-2-Microglobulin (B2M)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Porphobilinogen Deaminase (HEMC)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Adiponectin (ADIPOQ)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Gp120
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
    • Interleukin 33 (IL33)
    • Transforming Growth Factor, beta 1 (TGFB1)
  • Anwendung
    • Enzyme Immunoassay (EIA)
    • Western Blotting (WB)
  • Reaktivität
    • Hepatitis A Virus (HAV)
  • Wirt
    • Escherichia coli (E. coli)
  • Protein-Typ
    • Recombinant

Hepatitis A Virus P3C (HAV P3C) Protein Überblick

Protein Überblick

Capsid proteins VP1, VP2, and VP3 form a closed capsid enclosing the viral positive strand RNA genome. All these proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The capsid interacts with HAVCR1 to provide virion attachment to target cell (By similarity). {ECO:0000250}. Protein VP0: VP0 precursor is a component of immature procapsids. The N-terminal domain of VP0, protein VP4, is needed for the assembly of 12 pentamers into the icosahedral structure. Unlike other picornaviruses, HAV VP4 does not seem to be myristoylated and has not been detected in mature virions, supposedly owing to its small size. VP1-2A precursor is a component of immature procapsids and corresponds to an extended form of the structural protein VP1. The C-terminal domain of VP1-2A, protein 2A, acts as an assembly signal that allows pentamerization of P1-2A, which is the precursor of the structural proteins. 2A is proteolytically removed from particulate VP1-2A by a host protease and does not seem to be found in mature particles. Protein 2B and 2BC precursor affect membrane integrity and cause an increase in membrane permeability. Protein 2C: Associates with and induces structural rearrangements of intracellular membranes. It displays RNA- binding, nucleotide binding and NTPase activities (By similarity). {ECO:0000250}. Protein 3A, via its hydrophobic domain, serves as membrane anchor to the 3AB and 3ABC precursors. The 3AB precursor interacts with the 3CD precursor and with RNA structures found at both the 5'- and 3'-termini of the viral genome. Since the 3AB precursor contains the hydrophobic domain 3A, it probably anchors the whole viral replicase complex to intracellular membranes on which viral RNA synthesis occurs. The 3ABC precursor is targeted to the mitochondrial membrane where protease 3C activity cleaves and inhibits the host antiviral protein MAVS, thereby disrupting activation of IRF3 through the IFIH1/MDA5 pathway. In vivo, the protease activity of 3ABC precursor is more efficient in cleaving the 2BC precursor than that of protein 3C. The 3ABC precursor may therefore play a role in the proteolytic processing of the polyprotein. Protein 3B is covalently linked to the 5'-end of both the positive-strand and negative-strand genomic RNAs. It acts as a genome-linked replication primer. Protease 3C: cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind cooperatively to the protease. Also cleaves host proteins such as PCBP2. RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals.

Genbezeichner und Symbole assoziert mit HAV P3C

  • polyprotein a (alt.) (HAVgp1) Antikörper

Bezeichner auf Proteinebene für HAV P3C

hypothetical protein , polyprotein a (alt.)

GENE ID SPEZIES
1493918 Hepatovirus A
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