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The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. Zusätzlich bieten wir Ihnen HBa2 Antikörper (15) und viele weitere Produktgruppen zu diesem Protein an.
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Carriers of Hb Nanning are asymptomatic and could be missed by screening based on MCV and MCH (zeige PMCH Proteine) cutoffs of <80.0 fL and <27.0 pg, respectively. Both carriers of the mutation in the study have MCV and MCH (zeige PMCH Proteine) values that are 2 standard deviations (SDs (zeige SDS Proteine)) below normal, as would be predicted for an alpha+-thal.
Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (zeige VWF Proteine)) or type I collagen under shear stresses.
Hb Adana mutation was preferentially present in the alpha2-globin genes in Malays compared to the other ethnicities in Malaysia.
Seven novel nondeletional alpha-thalassemia mutations localized on the alpha2-globin gene in the heterozygous state were identified
Gene frequency for HBA2:c.301-24delGinsCTCGGCCC carriers among the Chinese population in Guangxi.
Hemoglobin Constant Spring mutation in Southeast Asians with thalassemia.
We report herein for the first time the description of HbA2' in the Tunisian population.
In maturing RBC (zeige CACNA1C Proteine) progenitors AHSP (zeige aHSP Proteine) bind to free alpha-globin (zeige HBA1 Proteine) chains to increase the HbA (zeige SCN2A Proteine) production. (Review)
Two mutations detected the -a(3,7) single gene deletion found in 75% of cases and the nongene deletion a2 IVS1 [-5nt (zeige ACPP Proteine)] in the remaining samples
Copy number variations in alpha-globin (zeige HBA1 Proteine) 2 gene is associated with increased levels of HbF with beta thalassemia.
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin\; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1\; some nondeletion alpha thalassemias have also been reported.
, 2-alpha-1 globin
, hemoglobin alpha 2 chain
, adult alpha D globin
, hemoglobin alpha-D chain
, hemoglobin subunit alpha-D
, hemoglobin, alpha 2
, hemoglobin subunit alpha
, globin, alpha 2
, hemoglobin, subunit alpha 2
, alpha globin
, alpha-2 globin
, hemoglobin alpha chain
, alpha T5 (aa 1-142)
, hemoglobin alpha-5 chain
, hemoglobin subunit alpha-5