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HHEX encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Zusätzlich bieten wir Ihnen Hematopoietically Expressed Homeobox Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HHEX Primary Antibody für WB - ABIN966283
Hromas, Radich, Collins: PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. in Biochemical and biophysical research communications 1993
Show all 2 Pubmed References
Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1 (zeige ATP6V0A1 Antikörper)) expression and a specific loss of the ventral pancreas.
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
Two differentiation-related genes, HHEX and HLX (zeige HLX Antikörper), are promoters of early phase reprogramming toward pluripotency.
This finding highlights the potentially functional alteration with HHEX rs1111875 and rs7923837 polymorphisms may increase colorectal cancer susceptibility.
The aim of this study was to examine the association between HHEX (rs5015480) and PROX1 (zeige PROX1 Antikörper) (rs340874) gene polymorphisms and Gestational diabetes mellitus (GDM) .The HHEX gene rs5015480 C allele may be a risk allele of GDM that is associated with increased BMI during pregnancy
Vascular smooth muscle protein kinase CK2 (zeige CSNK2A1 Antikörper) inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
HHEX over expression induced by human cytomegalovirus infection closely associated with vascular proliferative diseases.
The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 (zeige CDKAL1 Antikörper) SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 (zeige CDKAL1 Antikörper) and CDKN2A (zeige CDKN2A Antikörper)/B genes with T2DM but none of the two SNPs of HHEX.
These studies identify uPA (zeige PRAP1 Antikörper)-dependent de-repression of vegfr1 (zeige FLT1 Antikörper) and vegfr2 (zeige KDR Antikörper) gene transcription through binding to HHEX/PRH as a novel mechanism by which uPA (zeige PRAP1 Antikörper) mediates the pro-angiogenic effects of VEGF (zeige VEGFA Antikörper) and identifies a potential new target for control of pathologic angiogenesis.
Low HHEX mutation is associated with Thyroid Dysgenesis.
Data suggest that hematopoietically expressed homeobox protein (HHEX) downmodulation by promyelocytic leukemia (zeige PML Antikörper)-retinoic acid receptor alpha (zeige RARA Antikörper) fusion oncoprotein (PML (zeige PML Antikörper)-RARalpha (zeige RARA Antikörper)) is a key event during acute promyelocytic leukemia (zeige PML Antikörper) (APL (zeige FASL Antikörper)) pathogenesis.
Hhex binds to the Cdkn2a (zeige CDKN2A Antikörper) locus and directly interacts with the Polycomb (zeige CBX2 Antikörper)-repressive complex 2 (PRC2) to enable H3K27me3-mediated epigenetic repression
The Hhex evolutionarily conserved non-coding region appears to be a core node for the convergence of the transcription factor network that governs the emergence of Hematopoietic stem cells.
Hhex(-/-) mESCs fail to differentiate from definitive endoderm to hepatic endoderm.
results implicate Hhex in the maintenance of LT-HSCs and in lineage allocation from multipotent progenitors especially in stress hematopoiesis.
Data suggest that Hhex is a novel regulator of c-Myc (zeige MYC Antikörper) function that limits c-Myc (zeige MYC Antikörper) activity in transformed cells.
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2 (zeige LMO2 Antikörper)-transgenic mice.
Hhex is a key regulator of early lymphoid development, functioning, at least in part, via regulation of the cell cycle.
Hhex and Cer1 (zeige CER1 Antikörper) are indispensable components of the Sox17 (zeige SOX17 Antikörper) pathway for cardiopoiesis.
Hhex as the first transcriptional regulator specifically required for islet delta cells and suggest compromised paracrine control as a contributor to T2DM
Data suggest that GPC3 (zeige GPC3 Antikörper) down-regulates hepatocyte proliferation by binding to hedgehog (zeige SHH Antikörper) (HH) and down-regulating the HH signaling pathway and binding with CD81 (zeige CD81 Antikörper), thus making it unavailable to bind to Hhex and causing its nuclear translocation.
Hex expression and subcellular localization are associated with chondrocyte maturation
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Data suggest that zebrafish hhex appears to be activated by Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.
This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Homeobox protein PRH
, hematopoietically-expressed homeobox protein hhex
, homeobox protein hex
, homeodomain transcription factor
, hematopoietically expressed homeobox
, hematopoietically-expressed homeobox protein HHEX
, homeobox protein HEX
, homeobox protein PRH
, homeobox, hematopoietically expressed
, proline-rich homeodomain-containing transcription factor
, hematopoietically expressed homeobox protein
, hematopoietically expressed homeobox, related sequence 2
, hematopoietically-expressed homeobox protein Hhex