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The protein encoded by HPGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). Zusätzlich bieten wir Ihnen HPGDS Kits (13) und HPGDS Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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we have utilized a broad-scaled affinity proteomics approach to identify three proteins (CCL5 (zeige CCL5 Antikörper), HPGDS, and NPSR1 (zeige NPSR1 Antikörper)) with altered plasma levels in asthmatic children compared to healthy controls, representing the first evaluation of HPGDS and NPSR1 (zeige NPSR1 Antikörper) in plasma.
the development of a competition binding assay amenable to high-throughput screening (HTS (zeige APCDD1 Antikörper)) in a scintillation proximity assay (SPA (zeige FASL Antikörper)) format. This assay was used to screen an in-house compound library of approximately 280,000 compounds for novel H-PGDS inhibitors.
The effect of C. molle alkaloid extract on H-PGDS was studied. The alkaloid extract exhibited a 70% inhibition on H-PGDS with an IC50 of 13.7 mug/ml.
the Val187Ile HPGDS isoenzyme common among African Americans is not associated with colorectal cancer risk
COX-1 and H-PGDS were rapidly ubiquitinated and degraded through the ubiquitin-proteasome system in response to the elevation of the intracellular calcium level
In patients with mixed atrophy, testicular mast cell numbers and phenotypes change with respect to the ability to express COX2 (zeige COX2 Antikörper) and PGDS (zeige PTGDS Antikörper)-H.
New polymorphisms of haematopoietic prostaglandin D synthase (zeige PTGDS Antikörper)
Data suggest that the suppressive effect of hematopoietic prostaglandin D synthase on lung injury could be partly mediated by edema formation and inhibition of genes involved in fibrosis.
X-ray structure of human H-PGDS complexed with an inhibitor, 2-(2'-benzothiazolyl)-5-styryl-3-(4'-phthalhydrazidyl) tetrazolium chloride (BSPT) at 1.9 A resolution in the presence of Mg(2 (zeige MUC7 Antikörper)+).
PU.1 cooperates with MAPK (zeige MAPK1 Antikörper)-activated cJun (zeige JUN Antikörper) to maximally induce L-PGDS (zeige PTGDS Antikörper) expression in macrophages.
H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 (zeige MMP9 Antikörper) in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 (zeige MMP9 Antikörper) inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-).
HPGDS may play a role in the regulation of inflammation and epithelial cell health within the oviduct.
Data suggest a role for hematopoietic prostaglandin D synthase-produced prostaglandin D(2) in the initial nuclear translocation of SOX9 (zeige SOX9 Antikörper).
These data suggest that PGD(2) generated via HPGDS has detrimental effects after spinal cord injury and that blocking the activity of this enzyme can be beneficial.
hPGD (zeige HPGD Antikörper)(2)S-derived cyclopentenone prostaglandins may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection
Our results demonstrated that the neuroprotective effects of HPGDS in our model are mediated by suppression of activation and infiltration of inflammatory cells.
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
, glutathione S-transferase sigma
, glutathione-dependent PGD synthase
, glutathione-dependent PGD synthetase
, glutathione-requiring prostaglandin D synthase
, hematopoietic prostaglandin D2 synthase
, prostaglandin-H2 D-isomerase
, prostaglandin D2 synthase, hematopoietic
, glutathione S-transferase
, prostaglandin D2 synthase 2, hematopoietic
, prostaglandin-D synthase
, hematopoietic prostaglandin D synthase
, hematopoietic prostaglandin D synthase a
, prostaglandin D2 synthase, hematopoietic a