anti-Hematopoietic Cell Signal Transducer (HCST) Antikörper

Human Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

1. These results suggest that NKG2D (zeige KLRK1 Antikörper)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.

2. findings indicate that the functional interaction between RAGE (zeige AGER Antikörper) and DAP10 coordinately regulates S100A8 (zeige S100A8 Antikörper)/A9-mediated survival and/or apoptotic response of keratinocytes

3. TGF-beta1 (zeige TGFB1 Antikörper) may reduce the expression of NKG2D (zeige KLRK1 Antikörper)/DAP10 and 2B4 (zeige CD244 Antikörper)/SAPin patients with hepatitis B.

4. HMBOX1 (zeige HMBOX1 Antikörper) negatively regulates the expression of NKG2D (zeige KLRK1 Antikörper) and the activation of the NKG2D (zeige KLRK1 Antikörper)/DAP10 signaling pathway in NK cells.

5. Other gamma(c) cytokines act similarly to IL-2 (zeige IL2 Antikörper) in up-regulating DAP10 expression and NKG2D (zeige KLRK1 Antikörper)-DAP10 surface expression.

6. TGF-BETA1 (zeige TGFB1 Antikörper) down-modulates surface NKG2D (zeige KLRK1 Antikörper) expression by controlling the transcriptional and translational levels of DAP10.

7. A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12 (zeige TYROBP Antikörper), not the DAP10 adaptor protein.

8. NKG2D (zeige KLRK1 Antikörper)-DAP10 triggers human NK cell-mediated killing via a Syk (zeige SYK Antikörper)-independent regulatory pathway.

9. both activated and expanded CD8 (zeige CD8A Antikörper)+ T cells and NK cells use DAP10 for cytolysis

10. Downstream targets of DAP10 and DAP12 (zeige TYROBP Antikörper) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (zeige TYROBP Antikörper) dramatically reduces their lytic capacity.

Mouse (Murine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

1. Adoptive transfer of murine T cells expressing a chimeric-PD1 (zeige PDCD1 Antikörper)-Dap10 receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.

2. Rat and mouse CD94 (zeige KLRD1 Antikörper)/NKG2C (zeige KLRC2 Antikörper) heterodimers bind efficiently to both DAP12 (zeige TYROBP Antikörper) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (zeige KLRD1 Antikörper).

3. contributes to CD8 (zeige CD8A Antikörper)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

4. demonstrate a previously uncharacterized interaction of SHIP1 (zeige INPP5D Antikörper) with DAP12 (zeige TYROBP Antikörper) that limits TREM2 (zeige TREM2 Antikörper)- and DAP12 (zeige TYROBP Antikörper)-dependent signaling and identify a mechanism through which SHIP1 (zeige INPP5D Antikörper) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K

5. selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (zeige KLRK1 Antikörper)

6. Differential requirements for Vav (zeige VAV1 Antikörper) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.

7. The importance of Fcgr3 (zeige CD16 Antikörper)/Cd3z (zeige CD247 Antikörper), Hcst, and Tyrobp (zeige TYROBP Antikörper) in the activation of NK cells in the uterus of pregnant mice is reported.

8. Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (zeige GRB10 Antikörper) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.

9. DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.

10. improved rejection of B16 melanomas in DAP10-deficient mice

Cow (Bovine) Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

Zebrafish Hematopoietic Cell Signal Transducer (HCST) Interaktionspartner

1. The structure of the adaptor protein dap10 has been identified in the zebrafish genome.