HLA Class II DO alpha Proteine (HLA-DOA)

HLA-DOA belongs to the HLA class II alpha chain paralogues. Zusätzlich bieten wir Ihnen HLA-DOA Antikörper (36) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HLA-DOA 3111 P06340
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage

HLA-DOA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu HLA Class II DO alpha (HLA-DOA) Interaktionspartnern

Human HLA Class II DO alpha (HLA-DOA) Interaktionspartner

  1. Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis

  2. pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

  3. significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene.

  4. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population

  5. HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies.

  6. HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity

  7. results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation

  8. analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis

  9. HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias.

  10. In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.

  11. These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy.

  12. four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing

  13. minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product.

  14. HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1.

HLA-DOA Protein Überblick

Protein Überblick

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

Genbezeichner und Symbole assoziert mit HLA-DOA

  • major histocompatibility complex, class II, DO alpha (HLA-DOA)
  • HLA-DNA Protein
  • HLA-DZA Protein
  • HLADZ Protein

Bezeichner auf Proteinebene für HLA-DOA

HLA class II histocompatibility antigen, DO alpha chain , HLA-D0-alpha , MHC DN-alpha , MHC DZ alpha , MHC class II antigen DOA , lymphocyte antigen , major histocompatibility complex, class II, DN alpha

3111 Homo sapiens
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