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HLA-DOA belongs to the HLA class II alpha chain paralogues. Zusätzlich bieten wir Ihnen HLA-DOA Antikörper (35) und viele weitere Produktgruppen zu diesem Protein an.
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Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.
significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene.
TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population
HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies.
HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity
results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation
analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis
HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias.
In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.
These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy.
four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing
minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product.
HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1.
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
HLA class II histocompatibility antigen, DO alpha chain
, MHC DN-alpha
, MHC DZ alpha
, MHC class II antigen DOA
, lymphocyte antigen
, major histocompatibility complex, class II, DN alpha