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Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function.
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Human Monoclonal GDF9 Primary Antibody für Func, IHC (fro) - ABIN2473774
McHugh, Marshall, Ffytche, Hamilton, Raven: Diode laser trabeculoplasty (DLT) for primary open-angle glaucoma and ocular hypertension. in The British journal of ophthalmology 1991
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Human Polyclonal GDF9 Primary Antibody für IHC (p), WB - ABIN388822
Hendarto, Prabowo, Moeloek, Soetjipto: Growth differentiation factor 9 concentration in the follicular fluid of infertile women with endometriosis. in Fertility and sterility 2010
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These data suggested that Gdf9 is likely involved in promoting oocyte/ovary differentiation in the zebrafish and it may act by suppressing amh (zeige AMH Antikörper) expression, at least partly, in the somatic cells.
GDF9 expression was highest in primary growth follicles and gradually decreased during follicular development. Lowest level was found in fully grown follicles. It was maintained through fertilization and early embryonic development until gastrulation.
Asiaticoside hindered the invasive growth of KFs (zeige GDF6 Antikörper) by inhibiting the GDF-9/MAPK (zeige MAPK1 Antikörper)/Smad (zeige SMAD1 Antikörper) pathway.
Human GDF9 and BMP15 (zeige BMP15 Antikörper) act synergistically to stimulate granulosa cell proliferation, a response that also involves species-specific non-SMAD (zeige SMAD1 Antikörper) signalling pathways.
these results indicated that the GDF9 C447T SNP is a possible candidate genetic risk factor for female infertility in the Polish population.
GDF-9 promotes the proliferation and migration of keloid fibroblasts via a mechanism involving the Smad2 (zeige SMAD2 Antikörper)/3 pathway.
GDF9 c.169G>T (D57Y), c.546G>A (rs1049127), and BMP15 (zeige BMP15 Antikörper) rs79377927 (788_789insTCT) were associated with premature ovarian failure in the Chinese Hui population.
results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15 (zeige BMP15 Antikörper). Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.
GDF-9 and GDF-15 (zeige GDF15 Antikörper) levels may influence bone parameters in polycystic ovary syndrome
GDF9 and BMP15 (zeige BMP15 Antikörper) expression is reduced in primordial, primary, and secondary follicles in ovarian tissues of PCOS patients.
The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity.
Eleven unique copy number changes are identified in a total of 11 patients, including a tandem duplication of 475 bp, containing part of the GDF9 gene promoter region.
Data show that Rac1 induced nuclear import of STAT3 (zeige STAT3 Antikörper) by physical binding, and nuclear STAT3 (zeige STAT3 Antikörper) directly activated the transcription of essential oocyte-specific genes, including Jagged1 (zeige JAG1 Antikörper), GDF9 and BMP15 (zeige BMP15 Antikörper).
In organogenesis of the ovary, production of Dhh (zeige DHH Antikörper)/Ihh (zeige IHH Antikörper) in granulosa cells requires growth differentiation factor 9 from the oocyte.
The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity during heterodimer formation.
modified oocyte glycoproteins alter GDF9:BMP15 (zeige BMP15 Antikörper) expression modifying follicle development resulting in the generation of more follicles
A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha (zeige INHA Antikörper)(-/-) mouse model.
Embryo vitrification has no effect on ovarian morphology or expression of GDF9.
The results show that chronic unpredictable stress suppresses GDF9 expression.
show that purified mature regions of GDF9 and BMP15 (zeige BMP15 Antikörper) synergistically interact in a specific manner which is not dependent on the presence of a pro-region.
GDF9 may contribute to the variation observed in follicular development, ovulation rate, and fecundity between mammals
These results show that GDF9 and BMP15 (zeige BMP15 Antikörper) participate in cumulus expansion and that they stimulate MPF (zeige MSLN Antikörper) and MAPK (zeige MAPK1 Antikörper) activities in porcine oocytes during in vitro maturation.
Report temporal regulation of GDF9 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
injection of porcine GDF-9 gene resulted in an increase in the number of primary, secondary and tertiary ovarian follicles
Porcine GDF9 gene was found to be highly expressed in immature oocytes and declined slowly during the oocyte maturation process
GDF9 may be not associated with pig litter size in extensive populations as per the studies of allele distributions of the four polymorphisms and pilot association in four breeds.
Immunization against GDF9 and BMP15 (zeige BMP15 Antikörper), alone or together, altered follicular development and ovulation rate in cattle.
GDF9 expression in the oocytes of calf ovaries was significantly higher than in those of the adult ovaries
GDF-9 mediates its effect through the pathway commonly activated by TGF beta (zeige TGFB1 Antikörper) and activin (zeige Actbeta Antikörper), but not that activated by many BMPs
Maternal GDF9 transcripts persisted during oocyte in vitro maturation and fertilization and in preimplantation embryo until the five- to eight-cell or morula stage, but transcription was not reactivated at the time of embryonic genome activation.
Oocyte- and granulosa cell-derived GDF9 may simultaneously promote theca cell proliferation and prevent premature differentiation of the theca interna during early follicle development.
In this study, rabbits were distributed into two groups (poor and prolific offspring productions) and cloning and quantitative real-time PCR (qPCR) were employed to characterize the rabbit GDF9 gene. By cloning, 2515-bp genomic DNA and 1359-bp cDNA sequences were obtained
an indel mutation in GDF9 is significantly associated with litter size and growth traits in goats
A non-synonymous mutation in GDF9 is highly associated with litter size in Chinese cashmere goats
Studied six SNPs in goat BMPR1B (zeige BMPR1B Antikörper), BMP15 (zeige BMP15 Antikörper), and GDF9 for their association with litter size in seven breeds of Indian goats. Found no association between these SNPs and prolificacy in the breeds investigated.
Expression of BMP15 (zeige BMP15 Antikörper) (p < 0.01) and GDF9 (p < 0.05) mRNAs was more abundant in the small than the large antral follicles of Black Bengal goat.
GNRH1 (zeige GNRH1 Antikörper) and GDF9 genes could serve as genetic markers for litter size in goat breeding.
Mutation A959C in GDF9 gene has been associated with prolificacy.
Expression levels of follicular GDF9 and total ovarian BMPR1B (zeige BMPR1B Antikörper) were not different between the Lezhi black goat and the Tibetan goat.
These results provide further evidence that the GDF9 gene may be significantly correlated with high prolificacy in goats.
Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta superfamily.
growth and differentiation factor 9
, growth/differentiation factor 9
, growth differentiation factor-9