anti-Growth Differentiation Factor 11 (GDF11) Antikörper

Human Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. Plasma levels of GDF11 had a higher association with body mass and body composition than muscle function in older women.

2. Results show that GDF11 expression and activity were reduced in skin dermal fibroblasts deriving from adult donors compared to neonatal ones supporting the conclusions of GDF11 being an anti-ageing factor in humans.

3. Serum GDF11 levels were increased and negatively correlated with Hb levels and reticulocyte counts in AA patients. This suggests an impaired GDF11 response contributing to anemia in AA patients.

4. The serum content of GDF11 was much less in esophageal cancer patients than in the control group. Esophageal GDF II in cancer patients was correlated with cancer differentiation: the higher the degree of differentiation, the higher the content of GDF11.

5. Physical inactivity was significantly related to the decreased GDF11 levels in COPD.

6. GDF11 expression was decreased in COPD patients' serum and cells when compared with that of healthy people.

7. GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans

8. The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging.

9. Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer

10. These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.

11. In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.

12. A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble

13. MSTN, but not GDF11, declines in healthy men throughout aging.

14. GDF11 is highly concentrated in human platelets.

15. The crystal structure of GDF11 was determined to a resolution of 1.50 A.

16. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.

17. GDF11 inhibits rather than helps muscle regeneration.

18. Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.

19. in vitro sprout formation was increased as well by GDF11 treatment

20. Suggest GDF11 functions as encephalic regionalizing factor in neural differentiated mouse embryonic stem cells.

Mouse (Murine) Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. Suppression of cell-cycle progression may be a key mechanism by which GDF11 inhibited hepatocyte regeneration.

2. critical regulator of kidney fibrosis and tubular function

3. study indicates that GDF11/8 in the kidney decreases with age and that GDF11 can increase tubular cell dedifferentiation and proliferation as well as improve tubular regeneration after acute kidney injury (AKI) in old mice.

4. Our results showed that GDF11 inhibited osteoblastic differentiation of bone marrow mesenchymal stem cells in vitro and had no effect on osteoclast differentiation or bone resorption

5. In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor

6. we found that myostatin forms a complex with LTBP4 and that overexpression of LTBP4 led to a decrease in myostatin levels. LTBP4 also interacted with TGFbeta and GDF11, a protein highly related to myostatin. These data identify LTBP4 as a multi-TGFbeta family ligand binding protein with the capacity to modify muscle disease through overexpression

7. Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).

8. Data show that circulating myostatin levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin null mice indicate that they were almost 500 times lower than those for myostatin.

9. Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.

10. Therefore, we postulate that GDF-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues

11. Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.

12. GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.

13. Gdf11 stimulates expression of a Hoxd11/lacZ transgene in the mouse embryo tailbud.

14. GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo.

15. Gdf11 signaling is a major coordinator of the trunk-to-tail transition during mouse development

16. Using modified aptamer-based proteomics, study identified the TGF-beta superfamily member GDF11 as a circulating factor in young mice that declines with age.

17. Reducing GDF11 levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.

18. These results suggest that over-expression of BMP11 propeptide stimulates bone formation by increasing osteoblast cell functions.

19. PCSK5 and GDF11 expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.

20. the transition between stem cells and committed progenitors is neither sharp nor irreversible and GDF11, ACTbetaB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in this system

Zebrafish Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.