anti-Growth Differentiation Factor 11 (GDF11) Antikörper

Human Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. GDF11 may be a relevant myostatin (zeige MSTN Antikörper)-interacting peptide to successful aging in humans

2. The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN (zeige MSTN Antikörper)) in tissue specific aging.

3. Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer

4. These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8 (zeige MSTN Antikörper); however, the biological consequences of these differences remain to be determined.

5. In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.

6. A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble

7. MSTN (zeige MSTN Antikörper), but not GDF11, declines in healthy men throughout aging.

8. GDF11 is highly concentrated in human platelets.

9. The crystal structure of GDF11 was determined to a resolution of 1.50 A.

10. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.

Mouse (Murine) Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. Our results showed that GDF11 inhibited osteoblastic differentiation of bone marrow mesenchymal stem cells in vitro and had no effect on osteoclast differentiation or bone resorption

2. In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor

3. we found that myostatin (zeige MSTN Antikörper) forms a complex with LTBP4 (zeige LTBP4 Antikörper) and that overexpression of LTBP4 (zeige LTBP4 Antikörper) led to a decrease in myostatin (zeige MSTN Antikörper) levels. LTBP4 (zeige LTBP4 Antikörper) also interacted with TGFbeta (zeige TGFB1 Antikörper) and GDF11, a protein highly related to myostatin (zeige MSTN Antikörper). These data identify LTBP4 (zeige LTBP4 Antikörper) as a multi-TGFbeta (zeige TGFB1 Antikörper) family ligand binding protein with the capacity to modify muscle disease through overexpression

4. Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).

5. Data show that circulating myostatin (zeige MSTN Antikörper) levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin (zeige MSTN Antikörper) null mice indicate that they were almost 500 times lower than those for myostatin (zeige MSTN Antikörper).

6. Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.

7. Therefore, we postulate that GDF (zeige GDF5 Antikörper)-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues

8. Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.

9. GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.

10. Gdf11 stimulates expression of a Hoxd11 (zeige HOXD11 Antikörper)/lacZ (zeige GLB1 Antikörper) transgene in the mouse embryo tailbud.

Zebrafish Growth Differentiation Factor 11 (GDF11) Interaktionspartner

1. First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.