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GZMK product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes.
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these data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity
The data suggest that T-killer cells control lymphocytic choriomeningitis virus through non-cytotoxic processes that involve gzmK.
It was suggested that a high predisposition to catalepsy in mice can be defined by the Map3k1 (zeige MAP3K1 ELISA Kits), Il6st, Gzmk, and Hspb3 (zeige HSPB3 ELISA Kits) genes' coexpression network.
GzmK-induced caspase (zeige CASP3 ELISA Kits)-independent death occurs through Bid (zeige BID ELISA Kits)-dependent mitochondrial damage that is different from GzmA (zeige GZMA ELISA Kits)
grzK plays an important role in CD8 (zeige CD8A ELISA Kits)(+) T-cell cytotoxicity both in the presence and absence of grzA and B.
Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1.
Carbamate pesticides significantly reduced the intracellular levels of perforin (zeige PRF1 ELISA Kits), GrA (zeige NR3C1 ELISA Kits), GrB, Gr3 (zeige PRLHR ELISA Kits)/K, and GRN (zeige GRN ELISA Kits) in NK-92CI cells.
Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 (zeige TLR4 ELISA Kits) signaling during the antimicrobial innate immune response.
Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56 (zeige NCAM1 ELISA Kits)(bright) natural killer (NK) cells toward activated T cells.
Gr3 (zeige PRLHR ELISA Kits) proenzymes is activated by cathepsin C (zeige CTSC ELISA Kits) which concomitantly decreased the molecular weight to that of active Gr3 (zeige PRLHR ELISA Kits).
The present findings thus introduce the possibility that human beta-tryptase (zeige TPSAB1 ELISA Kits), after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart.
We found human GzmK triggers rapid cell death independently of caspase (zeige CASP3 ELISA Kits) activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks.
Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis.
GrK not only constitutes a redundant functional backup mechanism that assists GrA (zeige NR3C1 ELISA Kits)-induced cell death but that it also displays a unique function by cleaving its own specific substrates.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (zeige CCL2 ELISA Kits)) and interleukin-8 (IL-8 (zeige IL8 ELISA Kits)) decreased significantly in Dachengqi decoction treatment group.
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.
, granzyme 3
, granzyme K
, granzyme K (serine protease, granzyme 3; tryptase II)
, tryptase II