Golgin, RAB6-Interacting Proteine (GORAB)

GORAB encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. Zusätzlich bieten wir Ihnen Golgin, RAB6-Interacting Antikörper (82) und Golgin, RAB6-Interacting Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GORAB 92344 Q5T7V8
GORAB 98376 Q8BRM2
GORAB 304923 B1H222
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

GORAB Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Golgin, RAB6-Interacting (GORAB) Interaktionspartnern

Human Golgin, RAB6-Interacting (GORAB) Interaktionspartner

  1. Loss of RAB6-interacting golgin (GORAB) causes impairment of coat protein complex I (COPI)-mediated retrieval of trans-Golgi enzymes, resulting in a deficit in glycosylation of secretory cargo proteins.

  2. Novel compound heterozygous nonsense mutations were identified in the GORAB gene of a geroderma osteodysplastica patient.

  3. in the present study a de novo deletion on 1q23.3-q24.2 combined with a GORAB missense mutation leads to a distinctive phenotype with features from Gerodermia osteodysplastica and also short stature, cutis laxa, frequent fractures, facial dysmorphism, cup-shaped ears and intellectual disability

  4. SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 proteins, thus constituting a dual regulatory circuit

  5. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes

  6. SCYL1-BP1 plays a critical role in the regulation of EEA1, BMPR2 and BRCA2 expression.

  7. SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung SCC lines. Reintroduction of SCYL1BP1 into lung SCC lines significantly inhibited cell proliferation, migration, invasion and tumor formation.

  8. Data suggest that SCYL1-BP1 is a novel regulator of the MDM2-p53 feedback loop and that it may be a potential tumor suppressor.

  9. The chemotaxis signal pathway induced by chemokines CKbeta8 and CKbeta8-1 is mediated via the Gi/Go protein, phospholipase C (PLC) and protein kinase C delta (PKC delta).

  10. study supplements the limited available data on SCYL1BP1 and further establishes deficiency of this recently described golgin as the only known cause of geroderma osteodysplastica

  11. assessment of interaction with hPirh2

  12. Study demonstrates that gerodermia osteodysplastica is caused by loss-of-function mutations in SCYL1BP1, which is highly expressed in skin and osteoblasts.

Mouse (Murine) Golgin, RAB6-Interacting (GORAB) Interaktionspartner

  1. Gorab role in the abnormal osteoblast differentiation in the gerodermia osteodysplastica

  2. The G59S mutation in p150(glued) protein abrogates the normal function of the protein and accelerates motor neuron degeneration.

Golgin, RAB6-Interacting (GORAB) Protein Überblick

Protein Überblick

This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described.

Genbezeichner und Symbole assoziert mit GORAB

  • golgin, RAB6 interacting (GORAB)
  • golgin, RAB6-interacting (Gorab)
  • AI467484 Protein
  • GO Protein
  • NTKL-BP1 Protein
  • NTKLBP1 Protein
  • Scyl1bp1 Protein

Bezeichner auf Proteinebene für GORAB

N-terminal kinase-like-binding protein 1 , NTKL-binding protein 1 , RAB6-interacting golgin , SCY1-like 1 binding protein 1 , SCY1-like 1-binding protein 1 , SCYL1-BP1 , SCYL1-binding protein 1 , hNTKL-BP1 , dynactin 1, isoform 1; dynactin 1 (p150, Glued homolog); p150, Glued homolog; 150 kDa dynein-associated polypeptide; p150-glued , mNTKL-BP1 , NTKL-BP1

92344 Homo sapiens
98376 Mus musculus
304923 Rattus norvegicus
770613 Gallus gallus
490349 Canis lupus familiaris
614920 Bos taurus
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