anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) Antikörper

GGA3 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Zusätzlich bieten wir Ihnen GGA3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GGA3 260302 Q8BMI3
GGA3 360658  
GGA3 23163 Q9NZ52
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Top anti-GGA3 Antikörper auf antikoerper-online.de

Showing 10 out of 63 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GGA3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Thymus 100 μL 2 bis 3 Tage
$289.00
Details
Human Ziege Unkonjugiert ELISA, IHC   100 μg 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE antibody diluted at 1:2000 IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using GGA3, antibody at 1:100 dilution. 100 μL 3 bis 4 Tage
$466.18
Details
Schimpanse Kaninchen Unkonjugiert EIA, WB   0.1 mg 4 bis 8 Tage
$632.50
Details
Fledermaus Ziege Unkonjugiert ELISA, IHC, IHC (p) Human Kidney (formalin-fixed, paraffin-embedded) stained with GGA3 antibody ABIN364247 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-GGA3 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 bis 14 Tage
$484.00
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p), WB Human Breast (formalin-fixed, paraffin-embedded) stained with GGA3 antibody ABIN214349 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-GGA3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 bis 14 Tage
$550.00
Details
Hund Ziege Unkonjugiert EIA, IHC (p) Human Kidney (formalin-fixed, paraffin-embedded) stained with GGA3at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg 6 bis 8 Tage
$495.00
Details
Maus Kaninchen Unkonjugiert IHC, WB WB on rat brain lysate using Rabbit antibody to VHS domain of GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3): whole serum (ABIN350341) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band. 100 μL 7 bis 8 Tage
$454.67
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot using  Affinity Purified anti-GGA3 antibody shows detection of a band at ~110 kDa corresponding to GFP-GGA3 fusion protein present in a lysate of HEK293 cells over- expressing the recombinant protein (lane 2, arrowhead). Pre-incubation of antibody with immunizing peptide blocks specific staining (lane 3). MW markers are shown in lane 1 (700 nm channel - red). Approximately 35 µg of lysate was separated on a 16% Tricine gel by SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:600. Reaction occurred overnight at 4° C followed by washes and reaction with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L]  for 45 min at room temperature (800 nm channel - green). IRDye800 fluorescence image was captured using the Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results. ELISA results of purified Rabbit anti-GGA3 Antibody tested against BSA-conjugated peptide of immunizing peptide. Each well was coated in duplicate with 0.1µg of conjugate. The starting dilution of antibody was 5μg/ml and the X-axis represents the Log10 of a 3-fold dilution. This titration is a 4-parameter curve fit where the IC50 is defined as the titer of the antibody. Assay performed using 3% fish gel, Goat anti-Rabbit IgG Antibody Peroxidase Conjugated (Min X Bv Ch Gt GP Ham Hs Hu Ms Rt & Sh Serum Proteins)  and TMB ELISA Peroxidase Substrate . 100 μg 5 bis 7 Tage
$598.50
Details

Am meisten referenzierte anti-GGA3 Antikörper

  1. Dog (Canine) Polyclonal GGA3 Primary Antibody für ELISA - ABIN547498 : Prag, Lee, Mattera, Arighi, Beach, Bonifacino, Hurley: Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

Weitere Antikörper gegen GGA3 Interaktionspartner

Mouse (Murine) Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) Interaktionspartner

  1. GGA3 plays a key role in GABAergic transmission. GGA3 deletion results in decreased anxiety-like behaviors and increased BACE1 levels.

  2. depletion of GGA1 and GGA3 engender a rapid and robust elevation of BACE1 in the acute phase after brain injury. However, the efficient disposal of the acutely accumulated BACE1 solely depends on GGA3 levels in the subacute phase of injury

  3. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

Human Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) Interaktionspartner

  1. SNPs: rs6414624 in EVC and rs78338345 in GGA3 are novel susceptibility loci for type 2 diabetes mellitus in Japanese individuals.

  2. In the absence of GGA3, integrins are increasingly retained inside the cell, traffic toward the perinuclear lysosomal compartment and their degradation is enhanced.

  3. This work identifies GGA3 as a key player in a novel DXXLL-mediated endosomal sorting machinery that targets TrkA to the plasma membrane, where it prolongs the activation of Akt signaling and survival responses.

  4. role of GGA3 in the cell surface export of alpha2B-adrenergic receptor

  5. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  6. GGA3 is involved in the cellular processes relevant for Alzheimer's disease pathogenesis.

  7. Subcellular fractionation of Alzheimer's disease cortex with low levels of Golgi-localized GGA proteins shows an alteration of beta-secretase distribution and extensive co-localization with amyloid beta precursor protein APP.

  8. GGA3 tightly and inversely regulate BACE1 levels via interaction with ubiquitin sorting machinery

  9. structures of the VHS domain of human GGA3 complexed with signals from both mannose-6-phosphate receptors

  10. These results indicate that GGA3-S is predominantly expressed in human tissues except the brain and in cell lines.

  11. RNAi of GGA3 expression results in accumulation of the cation-independent mannose 6-phosphate receptor and internalized epidermal growth factor (EGF) within enlarged early endosomes. This perturbation impairs the degradation of internalized EGF.

  12. found that the human GGA3 protein GAT domain contains two ubiquitin binding motifs that bind to the same surface of ubiquitin

  13. GGA proteins funstion with the phosphorylated ACDL in the memasin 2-recycling pathway from endosomes to trans Golgi on the way back to the cell surface.

  14. crystal structure of the GAT domain

  15. GGA3, becomes transiently phosphorylated upon activation of the epidermal growth factor (EGF) receptor. (GGA3)

  16. CK2-activated phosphorylation cascade controlling PACS-1- and GGA3-mediated CI-MPR sorting, is reported.

  17. ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18

  18. These results show that the dual roles of PI4P can promote specific GGA targeting and cargo recognition at the trans-Golgi network.

  19. We have elucidated a GGA3-dependent mechanism regulating BACE levels and beta-secretase activity. This mechanism may explain increased cerebral levels of BACE and Abeta following cerebral ischemia and existing in AD.

  20. GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.

GGA3 Antigen-Profil

Protein Überblick

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene.

Genbezeichner und Symbole assoziert mit GGA3

  • golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Gga3) Antikörper
  • golgi associated, gamma adaptin ear containing, ARF binding protein 3 (GGA3) Antikörper
  • C230037M19Rik Antikörper
  • mKIAA0154 Antikörper

Bezeichner auf Proteinebene für GGA3

ADP-ribosylation factor-binding protein GGA3 , golgi-localized, gamma ear-containing, ARF-binding protein 3 , Golgi-localized, gamma ear-containing, ARF-binding protein 3 , golgi associated, gamma adaptin ear containing, ARF binding protein 3 , ADP-ribosylation factor binding protein 3

GENE ID SPEZIES
260302 Mus musculus
360658 Rattus norvegicus
23163 Homo sapiens
483310 Canis lupus familiaris
454877 Pan troglodytes
100172741 Pongo abelii
100525777 Sus scrofa
510539 Bos taurus
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