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The enzyme encoded by GLO1 is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Zusätzlich bieten wir Ihnen Glyoxalase I Antikörper (153) und Glyoxalase I Proteine (27) und viele weitere Produktgruppen zu diesem Protein an.
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Rat (Rattus) GLO1 ELISA Kit für Sandwich ELISA - ABIN432872
Sampath, Rashid, Sang, Ahmedna: Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway. in Food chemistry 2017
Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE (zeige AGER ELISA Kits) Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models
current research highlighted the Glo-I/AGE/RAGE (zeige AGER ELISA Kits) system as an interesting therapeutic target in chronic liver diseases. These findings need further elucidation in preclinical and clinical studies.
GLO1-knockdown provoked collagen expression, endothelial inflammation and dysfunction and apoptosis which might contribute to vascular damage
Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
Induced Glyoxalase 1 expression is a common feature in the pathogenesis of oropharyngeal squamous cell carcinoma
The lowering of glycative stress via modulation of RAGE (zeige AGER ELISA Kits)-AGE axis or glyoxalase 1 activity is beneficial for tubular homeostasis and the subsequent prevention and treatment of kidney disease, suggesting the possibility of novel therapeutic approaches which target glycative stress.
Glo-1 responds to dicarbonyl stress to enhance cytoprotection at the transcriptional level through stress-responsive increase of Glo-1 expression.
Glo1, together with Glo2 (zeige HAGH ELISA Kits), represents a novel mechanism in prostate cancer progression driven by a PTEN/PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) signaling pathway.
Gly82Ser and 2184 A/G RAGE (zeige AGER ELISA Kits) polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.
Reduction of GLO1 activity in atherosclerotic lesions of nondiabetic patients with increased HbA1c is associated with a functional involvement of this protective enzyme in atherogenesis.
Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.
the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.
These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior.
Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase (zeige AKR1B1 ELISA Kits) toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase (zeige AKR1B1 ELISA Kits).
Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.
Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution.
Study demonstrates that GLO1 is a novel metabolic oncogene (zeige RAB1A ELISA Kits) of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production.
the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice
The difference in glyoxalase-1 mRNA was observed with Fkbp5 (zeige FKBP5 ELISA Kits)-/- mice expressing 2-fold more glyoxylase-1 protein.
pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
S-D-lactoylglutathione methylglyoxal lyase
, glx I
, glyoxalase domain containing 1
, ketone-aldehyde mutase
, lactoyl glutathione lyase
, lactoylglutathione lyase
, glyoxalase 1 complex
, glyoxalase 1 regulatory
, glyoxalase 1 structural
, glyoxalase I
, hypothetical protein
, trypanothione-dependent glyoxalase I
, glyoxylase 1