Glyoxalase I (GLO1) ELISA Kits

The enzyme encoded by GLO1 is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Zusätzlich bieten wir Ihnen Glyoxalase I Antikörper (162) und Glyoxalase I Proteine (28) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GLO1 2739 Q04760
GLO1 109801 Q9CPU0
GLO1 294320 Q6P7Q4
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.59 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Ratte 0.58 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage

Am meisten referenzierte Glyoxalase I ELISA Kits

  1. Rat (Rattus) GLO1 ELISA Kit für Sandwich ELISA - ABIN432872 : Sampath, Rashid, Sang, Ahmedna: Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway. in Food chemistry 2017 (PubMed)

Weitere ELISA Kits für Glyoxalase I Interaktionspartner

Human Glyoxalase I (GLO1) Interaktionspartner

  1. There was no statistically significant association between p.P122fs in GLO1 and schizophrenia (P=0.25) in the Japanese population.

  2. GLO1 SNPs, rs1130534 (c.372A>T, p.G124G), rs2736654 (c.A332C, p.E111A) and rs1049346 (c.-7C>T, 5'-UTR) were genotyped. While c.A332C polymorphism was not associated with retinitis pigmentosa (RP), c.372A>T showed an allelic association. Conversely, c.-7C>T showed both genotypic and allelic associations. RP susceptibility may be associated with two of the analyzed GLO1 polymorphisms (rs1130534 and rs1049346).

  3. The active sites of human and staphylococcus glyoxalases I are also different: the former contains one Zn-ion per chain; the latter incorporates two of these ions.. We suggest that only single Zn1-ion plays the role of catalytic center. The newly found differences between the two subfamilies could guide the design of new drugs against S. aureus, an important pathogenic micro-organism.

  4. This study shows that only the GLO1 C-7T polymorphism, and not the GLO1 A419C and ALR C-106T polymorphisms, is associated with carotid atherosclerosis in Chinese patients with type 2 diabetes.

  5. The expression of glyoxalase system member glyoxalase 1 (GLO1) in melanoma cells is downregulated by miR-137. siRNA targeting of GLO1 mimicks inhibition of melanoma cell proliferation caused by miR-137 overexpression. Re-expression of GLO1 restores miR-137-mediated suppression of melanoma cell proliferation.

  6. The critical role of glyoxalases as regulators of tumorigenesis in the prostate through modulation of various critical signaling pathways, and an overview of the current knowledge on glyoxalases in bladder, kidney and testis cancers is reviewed.(GLO1, GLO2)

  7. Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models

  8. current research highlighted the Glo-I/AGE/RAGE system as an interesting therapeutic target in chronic liver diseases. These findings need further elucidation in preclinical and clinical studies.

  9. GLO1-knockdown provoked collagen expression, endothelial inflammation and dysfunction and apoptosis which might contribute to vascular damage

  10. expressed in basal epidermis; significantly higher expression in older individuals

  11. Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.

  12. Induced Glyoxalase 1 expression is a common feature in the pathogenesis of oropharyngeal squamous cell carcinoma

  13. The lowering of glycative stress via modulation of RAGE-AGE axis or glyoxalase 1 activity is beneficial for tubular homeostasis and the subsequent prevention and treatment of kidney disease, suggesting the possibility of novel therapeutic approaches which target glycative stress.

  14. Glo-1 responds to dicarbonyl stress to enhance cytoprotection at the transcriptional level through stress-responsive increase of Glo-1 expression.

  15. Glo1, together with Glo2, represents a novel mechanism in prostate cancer progression driven by a PTEN/PI3K/AKT/mTOR signaling pathway.

  16. Gly82Ser and 2184 A/G RAGE polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.

  17. Reduction of GLO1 activity in atherosclerotic lesions of nondiabetic patients with increased HbA1c is associated with a functional involvement of this protective enzyme in atherogenesis.

  18. Studies suggest that the enhancement of glyoxalase I (GLO-1) is a promising strategy aimed at halting the vicious cycle between chronic kidney disease and increases in glycative stress.

  19. GLO1 on one hand is crucial to maintaining tumor characteristics of malignant cells, and, on the other hand, supports malignant transformation of cells in a hypoxic environment when overexpressed.

  20. GLO1 SNPs are significantly associated with late-onset and drug-resistant epilepsy.

Mouse (Murine) Glyoxalase I (GLO1) Interaktionspartner

  1. Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.

  2. the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.

  3. These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior.

  4. Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase.

  5. Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.

  6. Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution.

  7. Study demonstrates that GLO1 is a novel metabolic oncogene of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production.

  8. Glyoxalase expression prevents against ischemic neuronal cell damage and ameliorates ischemic injury.

  9. the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice

  10. The difference in glyoxalase-1 mRNA was observed with Fkbp5-/- mice expressing 2-fold more glyoxylase-1 protein.

  11. pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.

  12. These results suggest that GLO-1 plays a role in high glucose-mediated signaling by reducing mesangial cells accumulation and oxidative stress in diabetes mellitus.

  13. Findings reveal that the abundance of GLO1 varies between different murine strains and within different sensory neuron populations.

  14. Data show that reducing RGS2 expression by antisense treatment prevented the increase in GLO1 and GSR1 mRNA and protein expression.

  15. Data demonstrate GLO1 expression and glycation damage to be induced by alpha-synuclein ablation leading to the suggestion that wild-type alpha-synuclein modulates brain glucose metabolism.

  16. Glo-I is a novel molecular target for treatment of Bcr-Abl(+) leukemias, and Abl TKI-resistant quiescent Bcr-Abl(+) leukemic cells that have acquired stem-like characteristics in the process of adapting to a hypoxic environment.

  17. Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE.

  18. Local overexpression in the mouse brain resulted in increased anxiety-like behaviour; Glo1 is involved in oxidative stress metabolism, linking this pathway with anxiety-related behaviour

  19. In diabetes there is an upregulation of glyoxalase I, but this upregulation is inadequate to normalize MGO levels, which could lead to MGO retention and chemical modification of proteins.

  20. Glo1 expression was upregulated in liver and hypothalamus of congenic mice when compared with B6 mice

Arabidopsis thaliana Glyoxalase I (GLO1) Interaktionspartner

  1. Methylglyoxal (MG) at 0.1 mM dose did not affect seedling growth, anthocyanin accumulation, MG contents, or activities of glyoxalases, whereas MG at 0.5 mM and 1 mM inhibited seedling growth and induced anthocyanin accumulation, MG accumulation, and glyoxalase (both I and II) activation.

Glyoxalase I (GLO1) Antigen-Profil

Beschreibung des Gens

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.

Genbezeichner und Symbole assoziert mit Glyoxalase I (GLO1) ELISA Kits

  • glyoxalase I (GLO1) Antikörper
  • glyoxalase 1 (Glo1) Antikörper
  • glyoxalase 1 (glo1) Antikörper
  • glyoxalase 1 L homeolog (glo1.L) Antikörper
  • glyoxalase 1 S homeolog (glo1.S) Antikörper
  • lactoylglutathione lyase (GST3) Antikörper
  • glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein (GLX1) Antikörper
  • lactoylglutathione lyase (STY1687) Antikörper
  • lactoylglutathione lyase (GLO1) Antikörper
  • glyoxalase I (Bcen_2094) Antikörper
  • glyoxalase I (gloA) Antikörper
  • glyoxalase I (Glo1) Antikörper
  • 0610009E22Rik Antikörper
  • 1110008E19Rik Antikörper
  • 2510049H23Rik Antikörper
  • ATGLX1 Antikörper
  • AW550643 Antikörper
  • cb554 Antikörper
  • F12F1.32 Antikörper
  • F12F1_32 Antikörper
  • Glo-1 Antikörper
  • Glo-1r Antikörper
  • Glo-1s Antikörper
  • GLO1 Antikörper
  • Glo1-r Antikörper
  • Glo1-s Antikörper
  • glod1 Antikörper
  • GLY1 Antikörper
  • glyi Antikörper
  • GLYOXALASE I Antikörper
  • glyoxalase I homolog Antikörper
  • Qglo Antikörper
  • trypanothione-dependent glyoxalase I Antikörper
  • wu:fb82g09 Antikörper
  • zgc:66035 Antikörper

Bezeichner auf Proteinebene für Glyoxalase I (GLO1) ELISA Kits

S-D-lactoylglutathione methylglyoxal lyase , aldoketomutase , glx I , glyoxalase domain containing 1 , ketone-aldehyde mutase , lactoyl glutathione lyase , lactoylglutathione lyase , methylglyoxalase , glyoxalase 1 complex , glyoxalase 1 regulatory , glyoxalase 1 structural , glyoxalase I , hypothetical protein , trypanothione-dependent glyoxalase I , glyoxylase 1

2739 Homo sapiens
109801 Mus musculus
368213 Danio rerio
421428 Gallus gallus
446359 Xenopus laevis
447401 Xenopus laevis
474894 Canis lupus familiaris
540335 Bos taurus
547925 Glycine max
594942 Xenopus (Silurana) tropicalis
719518 Macaca mulatta
748215 Pan troglodytes
837731 Arabidopsis thaliana
1248061 Salmonella enterica subsp. enterica serovar Typhi str. CT18
3639312 Candida albicans SC5314
4091104 Burkholderia cenocepacia AU 1054
4850985 Scheffersomyces stipitis CBS 6054
5073200 Leishmania infantum JPCM5
6924240 Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
6949741 Salmonella enterica subsp. enterica serovar Enteritidis str. P125109
100156085 Sus scrofa
294320 Rattus norvegicus
100726491 Cavia porcellus
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