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May constitute a glutathione peroxidase-like protective system against oxidative stresses (By similarity).
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Human Polyclonal GPX4 Primary Antibody für IHC, ELISA - ABIN185669
Su, Novoselov, Sun, Moustafa, Zhou, Oko, Hatfield, Gladyshev: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. in The Journal of biological chemistry 2005
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Guinea Pig Polyclonal GPX4 Primary Antibody für ELISA, WB - ABIN2473845
Nakagawa: Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor. in Biological & pharmaceutical bulletin 2004
Results suggest that single nucleotide polymorphism rs713041 in glutathione peroxidase 4 (GPx4) may play a key role in the pathogenesis of preeclampsia (PE).
Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy.
The results indicate that the single-nucleotide polymorphism rs713041 in GPX4 gene could modulate the pattern of global gene expression. Supplementation with Brazil nuts can modify the gene expression of some selenoproteins depending upon the presence of genetic polymorphisms.
GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes
The proliferation of GPx4 siRNA-treated cells was downregulated compared with that of control siRNA-treated cells. GPx4 knockdown enhanced hydrogen peroxide- and ferrous sulfate-induced cytotoxicity.
High GPX4 expression is associated with oral squamous cell carcinoma.
By screening peptide libraries displayed on T7 phages, and analyzing the X-ray crystal structures of the peptides, we successfully identified one peptide that binds to near Sec73 of catalytic site and two peptides that bind to another site on GPX4. To our knowledge, this is the first study reporting GPX4 inhibitory peptides and their structural information.
use GPX4 and GPX7 (zeige GPX7 Antikörper) as possible markers for improving HCC (zeige FAM126A Antikörper) diagnosis/prognosis.
One SNP (rs3746162) in GPX4 was significantly associated with bladder cancer recurrence after transurethral resection.
Hepatitis C virus (HCV) induces oxidative stress but controls it tightly by inducing ROS scavengers. Among these, GPx4 plays an essential role in the HCV life cycle.
We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.
Gpx4 was dispensable for the maintenance of cellular health and function of POMC (zeige POMC Antikörper) neurons, even in mice exposed to obesogenic conditions. In contrast, HFHS-fed mice with Gpx4 deletion from AgRP (zeige AGRP Antikörper) neurons displayed increased body adiposity. Gpx4 deletion from dopaminergic neurons induced anxiety behavior, and diminished spontaneous locomotor activity when DJ-1 (zeige PARK7 Antikörper) was co-deleted.
After tamoxifen treatment to ablate Gpx4, Gpx4BIKO mice developed impairment in hippocampus dependent spatial learning and memory function which was associated with neurodegeneration. Consistent with its role as a regulator of ferroptosis, cognitive impairment and neurodegeneration in Gpx4BIKO mice was associated with elevated lipid peroxidation, ERK(1 (zeige MAPK3 Antikörper)/2) activation and overt neuroinflammation.
The structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported.
ferroptosis regulator Gpx4 is critical for hepatocyte survival and proper liver function, and that vitamin E can compensate for its loss by protecting cells against deleterious lipid peroxidation.
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
Phospholipid hydroperoxide glutathione peroxidase (zeige GPX1 Antikörper) is involved in the maintenance of male fertility under cryptorchidism in mice
dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo
The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice.
Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice.
GPx4 suppresses the increase in the VEGF-A protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV.
GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.
, phospholipid hydroperoxide glutathione peroxidase, mitochondrial
, sperm nucleus glutathione peroxidase
, phospholipid hydroperoxide glutathione peroxidase, nuclear
, glutathione peroxidase 4
, sperm nuclei glutathione peroxidase
, glutathione peroxidase 4 (phospholipid hydroperoxidase)
, phospholipid hydroperoxide glutathione peroxidase