anti-Glutathione Peroxidase (GPX4) Antikörper

May constitute a glutathione peroxidase-like protective system against oxidative stresses (By similarity). Zusätzlich bieten wir Ihnen GPX4 Proteine (11) und GPX4 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GPX4 2879 P36969
GPX4 29328 P36970 , Q91XR8
GPX4 625249 O70325 , Q91XR9
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Top anti-GPX4 Antikörper auf

Showing 10 out of 107 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN185669 (0.1µg/ml) staining of Human Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185669 (0.3µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert IHC (p), WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
Human Kaninchen Unkonjugiert ELISA, ICC, IF, IHC, WB Western blot analysis of Hela cell lysate, using GPX4 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276964 staining HepG2? cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
Human Maus Unkonjugiert IP, ELISA 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Testis Tissue; Lane2: Mouse Heart Tissue. 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
Meerschweinchen Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage
Human Ziege Unkonjugiert ELISA, IHC, IHC (p), WB Human Testis (formalin-fixed, paraffin-embedded) stained with GPX4 antibody ABIN461940 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. Anti-GPX4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GPX4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms ... 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
Rind (Kuh) Ziege Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 4 bis 8 Tage

Am meisten referenzierte anti-GPX4 Antikörper

  1. Human Polyclonal GPX4 Primary Antibody für IHC, ELISA - ABIN185669 : Su, Novoselov, Sun, Moustafa, Zhou, Oko, Hatfield, Gladyshev: Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. in The Journal of biological chemistry 2005 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal GPX4 Primary Antibody für IP, ELISA - ABIN532609 : Avissar, Eisenmann, Breen, Horowitz, Miller, Cohen: Human placenta makes extracellular glutathione peroxidase and secretes it into maternal circulation. in The American journal of physiology 1994 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal GPX4 Primary Antibody für IHC, WB - ABIN6669813 : Wang, Zheng, Zhang, Zhao, Wang, Wang, Shang, Barasch, Qiu: Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury. in American journal of physiology. Renal physiology 2018 (PubMed)

Weitere Antikörper gegen GPX4 Interaktionspartner

Human Glutathione Peroxidase (GPX4) Interaktionspartner

  1. GPX4 regulates reactive oxygen species-induced cell death.

  2. that polymorphisms in GPX1 and GPX4 are significantly associated with episodic memory and AD in a South Brazilian population

  3. Crystal structure and functional characterization of selenocysteine-containing GPX4 suggests an alternative mechanism of peroxide reduction.

  4. Results suggest that single nucleotide polymorphism rs713041 in glutathione peroxidase 4 (GPx4) may play a key role in the pathogenesis of preeclampsia (PE).

  5. Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy.

  6. The results indicate that the single-nucleotide polymorphism rs713041 in GPX4 gene could modulate the pattern of global gene expression. Supplementation with Brazil nuts can modify the gene expression of some selenoproteins depending upon the presence of genetic polymorphisms.

  7. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes

  8. The proliferation of GPx4 siRNA-treated cells was downregulated compared with that of control siRNA-treated cells. GPx4 knockdown enhanced hydrogen peroxide- and ferrous sulfate-induced cytotoxicity.

  9. High GPX4 expression is associated with oral squamous cell carcinoma.

  10. By screening peptide libraries displayed on T7 phages, and analyzing the X-ray crystal structures of the peptides, we successfully identified one peptide that binds to near Sec73 of catalytic site and two peptides that bind to another site on GPX4. To our knowledge, this is the first study reporting GPX4 inhibitory peptides and their structural information.

  11. use GPX4 and GPX7 as possible markers for improving HCC diagnosis/prognosis.

  12. One SNP (rs3746162) in GPX4 was significantly associated with bladder cancer recurrence after transurethral resection.

  13. Hepatitis C virus (HCV) induces oxidative stress but controls it tightly by inducing ROS scavengers. Among these, GPx4 plays an essential role in the HCV life cycle.

  14. GPX1, GPX3, and GPX4 genes may play a role in clear cell renal cell carcinoma cancerogenesis.

  15. polymorphism of gene of glutathione peroxidase predisposes to more severe affection of liver and progression of chronic hepatitis C.

  16. GPx4 is essential for maintaining oxidative homeostasis and keeping defense against oxidative stress in conjunctival epithelial cells.

  17. Identification of truncating mutations in GPX4 in two families affected with Sedaghatian-type spondylometaphyseal dysplasia.

  18. GPX4c718t SNP is functional and that variants of this SNP can have detrimental consequences on endothelial function leading to a greater risk of vascular disease.

  19. A membrane glycoprotein GPX4 was shown to play a significant role in gamete interactions.

  20. Erythrocyte glutathione peroxidase activity is modified by single nucleotide polymorphisms in SEPP1, GPX4 and GPX1 and by estrogens.

Zebrafish Glutathione Peroxidase (GPX4) Interaktionspartner

  1. We found that the gpx4b gene shows maternal and zygotic gene expression in the embryo proper compared to gpx4a that showed zygotic gene expression in the periderm covering the yolk cell only.

Mouse (Murine) Glutathione Peroxidase (GPX4) Interaktionspartner

  1. Genetic inactivation of GPX4 increases lipid peroxidation, thus exacerbating GSDMD-mediated pyroptosis in macrophages as well as septic lethality in mice.

  2. Selenium-containing GPX4 is necessary for full viability of mice. Survival of a specific type of interneurons depends on selenocysteine-containing GPX4, thereby preventing fatal epileptic seizures.

  3. paternal acetylated histones and acrosomal nuclear GPx4 are directly involved in fertilization.

  4. Gpx4 was dispensable for the maintenance of cellular health and function of POMC neurons, even in mice exposed to obesogenic conditions. In contrast, HFHS-fed mice with Gpx4 deletion from AgRP neurons displayed increased body adiposity. Gpx4 deletion from dopaminergic neurons induced anxiety behavior, and diminished spontaneous locomotor activity when DJ-1 was co-deleted.

  5. After tamoxifen treatment to ablate Gpx4, Gpx4BIKO mice developed impairment in hippocampus dependent spatial learning and memory function which was associated with neurodegeneration. Consistent with its role as a regulator of ferroptosis, cognitive impairment and neurodegeneration in Gpx4BIKO mice was associated with elevated lipid peroxidation, ERK(1/2) activation and overt neuroinflammation.

  6. The structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported.

  7. ferroptosis regulator Gpx4 is critical for hepatocyte survival and proper liver function, and that vitamin E can compensate for its loss by protecting cells against deleterious lipid peroxidation.

  8. These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.

  9. Phospholipid hydroperoxide glutathione peroxidase is involved in the maintenance of male fertility under cryptorchidism in mice

  10. dramatic motor neuron degeneration and paralysis induced by Gpx4 ablation suggest that ferroptosis inhibition by GPX4 is essential for motor neuron health and survival in vivo

  11. The lack of catalytic activity is the major reason for the embryonic lethality of Gpx4 knockout mice.

  12. Homozygous expression of Gpx4 with a targeted substitution of selenocysteine to serine causes early embryonic death as expected but, unexpectedly, male subfertility in heterozygous mice.

  13. GPx4 suppresses the increase in the VEGF-A protein level, which occurs during the development of pathological CNV, thus partly explaining the protective effect of GPx4 against CNV.

  14. Inducible disruption of Gpx4 causes acute renal failure and early death in an Alox15-independent manner

  15. A membrane glycoprotein GPX4 was shown to play a significant role in gamete interactions.

  16. Rat Gpx4 is a moonlighting protein that functions both as a peroxidase, as well as a structural protein.

  17. GPx4-overexpressing mice showed no free fatty acid induced increase in reactive oxygen species and lipid peroxidation

  18. Activity of cutaneous GPx4 is linked to the regulation of COX-2 and hair follicle morphogenesis and provides insight into the function of individual selenoprotein activity in maintaining cutaneous homeostasis.

  19. enzymatic epididymal salvage response is sufficient to maintain full fertility of double GPx4 and GPx5 KO males whatever their age, crossed with young WT female mice

  20. Tam treatment also significantly elevated apoptosis in Gpx4(f/f)/Cre mice. Moreover, tam-treated Gpx4(f/f)/Cre mice showed neuronal loss in the hippocampus region and had increased astrogliosis

Cow (Bovine) Glutathione Peroxidase (GPX4) Interaktionspartner

  1. GPx-4 has an important role in the physiological control of peroxide tone in the bordering cells of the oviductal lumen

GPX4 Antigen-Profil

Protein Überblick

Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified.

Genbezeichner und Symbole assoziert mit GPX4

  • glutathione peroxidase 4 (GPX4) Antikörper
  • glutathione peroxidase 4 (Gpx4) Antikörper
  • glutathione peroxidase 4a (gpx4a) Antikörper
  • 1700027O09Rik Antikörper
  • ATGPX4 Antikörper
  • cb563 Antikörper
  • cb691 Antikörper
  • F11L15.5 Antikörper
  • glutathione peroxidase 4 Antikörper
  • GP-GPx4 Antikörper
  • gpx-4 Antikörper
  • GSHPx-4 Antikörper
  • MCSP Antikörper
  • mtPHGPx Antikörper
  • Phgpx Antikörper
  • PHGPxa Antikörper
  • sb:cb563 Antikörper
  • snGpx Antikörper
  • snPHGPx Antikörper
  • wu:fb82e03 Antikörper
  • zgc:92253 Antikörper

Bezeichner auf Proteinebene für GPX4

phospholipid hydroperoxidase , phospholipid hydroperoxide glutathione peroxidase, mitochondrial , sperm nucleus glutathione peroxidase , GSHPx-4 , phospholipid hydroperoxide glutathione peroxidase, nuclear , glutathione peroxidase 4 , GPx-4 , sperm nuclei glutathione peroxidase , glutathione peroxidase 4 (phospholipid hydroperoxidase) , phospholipid hydroperoxide glutathione peroxidase

2879 Homo sapiens
29328 Rattus norvegicus
352928 Danio rerio
625249 Mus musculus
819427 Arabidopsis thaliana
399537 Sus scrofa
286809 Bos taurus
100730119 Cavia porcellus
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