Glutamate Decarboxylase 1 (Brain, 67kDa) Proteine (GAD1)

GAD1 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Zusätzlich bieten wir Ihnen GAD Antikörper (185) und GAD Kits (36) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GAD1 14415 P48318
GAD1 24379 P18088
GAD1 2571 Q99259
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human His tag 10 μg Anmelden zum Anzeigen 2 bis 3 Tage
Baculovirus infected Insect Cells Human His tag 50 μg Anmelden zum Anzeigen 20 bis 21 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 2 bis 3 Tage

GAD1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human , , , ,
, ,

Weitere Proteine zu Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartnern

Mouse (Murine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. The UCHL1 (zeige UCHL1 Proteine) may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation.

  2. GABA is the major inhibitory neurotransmitter in the brain. We show that Dlx1/Dlx2 homeobox (zeige PRRX1 Proteine) genes regulate GABA synthesis during forebrain development through direct activation of glutamic acid decarboxylase enzyme isoforms that convert glutamate (zeige GRIN1 Proteine) to GABA.

  3. our study provides novel insights into the mechanisms of UCH-L1 (zeige UCHL1 Proteine)-mediated neurobiological functions and suggests that ubiquitination is an important regulatory signal for TrkB (zeige NTRK2 Proteine)

  4. These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.

  5. Study describes in detail a population of choline acetyltransferase immunoreactive /glutamate decarboxylase 67 neurons predominantly ventral to the central canal of the cervical, thoracic and lumbar spinal cord of adult and juvenile mice. These cells potentially correspond to a sub-population of the cholinergic central canal cluster cells which may play a unique role in controlling spinal cord circuitry.

  6. This study demonstrated that Alterations in hypoglossal motor neurons due to GAD67 deficiency in mice.

  7. Treadmill running prevented partial sciatic nerve ligation-induced reductions in GAD65 (zeige GAD2 Proteine)/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn.

  8. Effects of Ubiquitin C-Terminal Hydrolase (zeige UCHL1 Proteine) L1 (UCH-L1 (zeige UCHL1 Proteine)) inhibition on sperm incorporation and cortical tension in mouse eggs.

  9. Gad1 knockdown mice have pronounced sensorimotor gating deficits, increased novelty-seeking and reduced fear extinction

  10. The neuronal marker UCH-L1 (zeige UCHL1 Proteine) is induced in, and specifically augments the oncogene (zeige RAB1A Proteine)-induced transformation of, germinal center B cells.

Arabidopsis thaliana Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM lobes role in interactions between CaM and plant GAD.

  2. Insertion mutants of GAD1 revealed that GABA levels in roots were drastically reduced compared with those in the wild type.

  3. Calmodulin activates Gad1 in a unique way by relieving two C-terminal autoinhibition domains of adjacent active sites, forming a 393 kDa Gad1-calmodulin complex with an unusual 1:3 stoichiometry.

Human Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. findings converge on variation in glutamic acid decarboxylase 1 gene predicting a susceptibility mechanism that affects white matter fractional anisotropy, GABAergic inhibitory neurotransmission in the dorsolateral prefrontal cortex, and working memory performance.

  2. Results show how epigenetic changes in GAD1 expression alter local glutamate (zeige GRIN1 Proteine) metabolism in the brain metastatic microenvironment, contributing to a metabolic adaption that facilitates metastasis outgrowth in that setting.

  3. We investigate the possible influence of GAD1 SNPs rs3749034 and rs11542313 on ADHD susceptibility. The C allele of rs11542313 was significantly overtransmitted from parents to ADHD probands. Hyperactive/impulsive score was higher in rs3749034G allele and rs11542313C allele carriers. GAD1 haplotypes were associated with higher hyperactive/impulsive scores in ADHD youths. GAD1 gene is associated with ADHD susceptibility.

  4. GAD1 is reactivated by DNA methylation (zeige HELLS Proteine), which provided a model for DNA methylation (zeige HELLS Proteine) and the active orchestration of oncogenic gene expression by CTCF (zeige CTCF Proteine) in cancer cells.

  5. There was no difference in GAD25 and GAD67 gene expression level, and GAD25/GAD67 ratio between patients with first episode psychosis and healthy controls

  6. Genetic variability in GAD1 and GAD2 (zeige GAD2 Proteine) contributes to the risk of methamphetamine dependence in the Thai population.

  7. Reduced GAD67 expression in PV neurons is not an upstream cause of the lower levels of GABA-associated transcripts, or of the characteristic behaviors, in schizophrenia.

  8. Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Here, we used recombinant herpes simplex virus (HSV-1) vectors that encode gad1 gene to evaluate the therapeutic potential of GAD67 in peripheral HIV gp120 (zeige ITIH4 Proteine)-induced neuropathic pain

  9. This study showed that in female groups, the expression of GABRA5 (zeige GABRA5 Proteine) was generally higher in schizophrenia cases compared to the control.

  10. GAD autoantibodies were associated with risk of developing type 1 diabetes.

Cow (Bovine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. These results suggest that the GAD1 gene is a strong candidate gene that affects growth traits in cattle.

Zebrafish Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon

  2. High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium

  3. the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations

GAD (GAD1) Protein Überblick

Protein Überblick

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Genbezeichner und Symbole assoziert mit GAD1

  • glutamate decarboxylase 1 L homeolog (gad1.1.L)
  • glutamate decarboxylase 1 (GAD1)
  • glutamate decarboxylase 2 (GAD2)
  • glutamate decarboxylase 1 (AOR_1_946174)
  • glutamate decarboxylase 1 (AOR_1_562034)
  • glutamate decarboxylase 1 (Gad1)
  • glutamate decarboxylase (GAD)
  • glutamate decarboxylase 1b (gad1b)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • AO090005000539 Protein
  • AO090103000342 Protein
  • AW822034 Protein
  • C88048 Protein
  • CPSQ1 Protein
  • EP10 Protein
  • gad Protein
  • Gad-1 Protein
  • GAD-67 Protein
  • GAD1 Protein
  • gad1-A Protein
  • GAD2 Protein
  • GAD25 Protein
  • GAD44 Protein
  • Gad67 Protein
  • glutamate decarboxylase Protein
  • MKP11.30 Protein
  • MKP11_30 Protein
  • PGP9.5 Protein
  • PGP 9.5 Protein
  • R75593 Protein
  • SCP Protein
  • UCH-L1 Protein
  • UCHL-1 Protein

Bezeichner auf Proteinebene für GAD1

glutamate decarboxylase 1 , glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamic acid decarboxylase 65-like protein , 67 kDa glutamic acid decarboxylase , GAD-67 , GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE) , glutamate decarboxylase 67 kDa isoform , glutamic acid decarboxylase 1 , Glutamate decarboxylase 1 (brain) , glutamate decarboxylase 1 variant GAD67NT , glutamic acid decarboxylase , glutamate decarboxylase 67 , glutamate decarboxylase, 67 kDa isoform , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin thioesterase L1

378551 Xenopus laevis
778442 Taeniopygia guttata
778447 Taeniopygia guttata
5989537 Aspergillus oryzae RIB40
5999037 Aspergillus oryzae RIB40
100173252 Pongo abelii
14415 Mus musculus
24379 Rattus norvegicus
831599 Arabidopsis thaliana
2571 Homo sapiens
493699 Felis catus
478794 Canis lupus familiaris
396928 Sus scrofa
517552 Bos taurus
395743 Gallus gallus
468557 Pan troglodytes
378441 Danio rerio
22223 Mus musculus
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