anti-Glial Cells Missing Homolog 2 (Drosophila) (GCM2) Antikörper

GCM2 is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GCM2 9247 O75603
GCM2 107889 O09102
GCM2 291047  
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Top anti-GCM2 Antikörper auf antikoerper-online.de

Showing 10 out of 39 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: GCM2 Sample Tissue: Human Hela Whole Cell Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A431 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
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Human Kaninchen Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen Verfügbar
$181.73
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$507.83
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Human Kaninchen Cy3 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$416.90
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Human Kaninchen Cy5 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$416.90
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Human Kaninchen Cy5.5 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$416.90
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Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$416.90
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Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$416.90
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Weitere Antikörper gegen GCM2 Interaktionspartner

Zebrafish Glial Cells Missing Homolog 2 (Drosophila) (GCM2) Interaktionspartner

  1. Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac-expressing ionocytes and Ca2+ uptake.

  2. PTH1 morphants failed to express gcm2. Coinjection of PTH1 morpholino with gcm2 capped RNA rescued the phenotypes observed in the PTH1 morphants, suggesting that the defects in PTH1-deficient fish were caused, at least in part, by the suppression of gcm2.

  3. merovingian mutants showed an acidified extracellular environment in the vicinity of both inner ear and lateral line hair cells.

  4. Results suggest that an acquisition of enhancers for the expression of gcm2 contributes to a diversity of ionocytes in zebrafish during evolution.

  5. role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  6. required for normal pharyngeal cartilage formation

  7. Results suggest a role for glial cells missing 2 during the evolution of divergent pharyngeal morphologies.

  8. Gcm-2 is required for the formation of the internal gill buds in zebrafish

  9. The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish.

Human Glial Cells Missing Homolog 2 (Drosophila) (GCM2) Interaktionspartner

  1. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA).

  2. GCM2-associated primary hyperparathyroidism patients have greater preoperative parathyroid hormone levels, a greater rate of multigland disease, a lesser rate of biochemical cure

  3. Our results demonstrate that germline-activating mutations affecting the C-terminal conserved inhibitory domain of GCM2 can cause familial isolated hyperparathyroidism.

  4. Gata3 interacted with Gcm2 and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH promoter.

  5. The higher frequency of GCM2 282D in primary hyperparathyroidismand enhanced transcriptional activity of this variant supports the notion that it could contribute causally to parathyroid tumorigenesis

  6. we identified the genetic defect in 35% of hypoparathyroidism patients in our cohort and discovered novel GCM2 mutations including submicroscopic deletion that was undetectable by array comparative genomic hybridization

  7. Four single nucleotide polymorphisms of GCMB gene were found in the GCMB gene (c.-44T > C [rs16870746], c.91-242A > G [rs9379881], c.343+163G > A [rs9393726], and c.583-72A > T [rs2076257]) in our cohort.

  8. First described GCM2 mutation in exon 3 in patients with severe congenital hypoparathyroidism.

  9. Data suggest that replacement of cysteine 106 with arginine (C106R) would interfere with DNA binding of glial cells missing B (GCMB).

  10. We conclude that mutations in the transcription factor GCMB do not seem to play a major role in the pathogenesis of primary hyperparathyroidism.

  11. These results indicate that GCMB and vitamin D receptor are involved in the positive and negative regulation of parathyroid hormone gene expression, respectively.

  12. Gcm2 is a useful adjunct marker for the diagnosis of parathyroid lesions.

  13. Our results have identified the first dominant missense GCMB mutation and help to increase our understanding of the mechanism underlying gene transactivation that is a prerequisite for the function of this parathyroid gland-specific transcription factor.

  14. These results expand the spectrum of hypoparathyroidism-associated GCMB mutations and help elucidate the molecular mechanisms underlying DNA-binding and transactivation that are required for this parathyroid-specific transcription factor.

  15. significant association of R110W variant of GCM2 with isolated hypoparathyroidism

  16. The glial cell missing gene, GCMB , encodes a transcription factor, which is a master regulator of parathyroid development. GCMB expression is upregulated in abnormal parathyroid glands of hyperparathyroidism and decreases in response to hypocalcemia.

  17. Although GCM2 mutations appear to be an uncommon cause of isolated hypoparathyroidism, the wide variety of GCM2 polymorphisms suggests that variant alleles may have a role in determining parathyroid function.

  18. The dominant-negative effect observed in vitro for both GCMB mutations provides a plausible explanation for the impaired PTH secretion observed in the two unrelated families with autosomal dominant form of hypoparathyroidism.

  19. Glial cells missing-2 (GCM2) transactivates the calcium-sensing receptor gene

  20. one function of Gcm2 is to maintain high levels of CaR expression in parathyroid cells.

Mouse (Murine) Glial Cells Missing Homolog 2 (Drosophila) (GCM2) Interaktionspartner

  1. results suggest that MafB regulates later steps of parathyroid development, that is, separation from the thymus and migration toward the thyroid. MafB also regulates the expression of PTH in cooperation with Gcm2

  2. Gcm2 (glial cells missing 2) are involved in the epigenetic regulation of Hes5 transcription by DNA demethylation independently of DNA replication.

  3. role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium

  4. GCM domain as a new type of Zn-coordinating, sequence-specific DNA-binding domain.

  5. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia.

GCM2 Antigen-Profil

Protein Überblick

This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism.

Genbezeichner und Symbole assoziert mit GCM2

  • glial cells missing homolog 2 (GCM2) Antikörper
  • glial cells missing homolog 2 (Drosophila) (gcm2) Antikörper
  • glial cells missing homolog 2 S homeolog (gcm2.S) Antikörper
  • glial cells missing homolog 2 (Drosophila) (Gcm2) Antikörper
  • glial cells missing homolog 2 (Gcm2) Antikörper
  • gcm-2 Antikörper
  • Gcm-rs1 Antikörper
  • Gcm1 Antikörper
  • Gcm1-rs2 Antikörper
  • GCMB Antikörper
  • hGCMb Antikörper

Bezeichner auf Proteinebene für GCM2

chorion-specific transcription factor GCMb , glial cells missing 2 , gcmB transcription factor , glial cell missing-like protein , transcription factor glial cells missing-2 , transcription factor Glial cells missing-2 , glial cells missing protein homolog 2 , glial cells missing homolog 2 , GCM motif protein 2 , glial cells missing homolog b , glide/gcm protein homolog , mGCMb

GENE ID SPEZIES
428478 Gallus gallus
449615 Danio rerio
496398 Xenopus laevis
539454 Bos taurus
100228942 Taeniopygia guttata
100358264 Oryctolagus cuniculus
9247 Homo sapiens
107889 Mus musculus
488217 Canis lupus familiaris
291047 Rattus norvegicus
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