anti-Gigaxonin (GAN) Antikörper

GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. Zusätzlich bieten wir Ihnen GAN Kits (10) und GAN Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GAN 209239 Q8CA72
GAN 307893  
GAN 8139 Q9H2C0
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Top anti-GAN Antikörper auf

Showing 10 out of 44 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GAN Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: THP-1 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert IP Immunoprecipitation: Gigaxonin Antibody [NBP1-49924] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Gigaxonin antibody NBP1-49924 used for IP at 3 ug/mg lysate. Gigaxonin was also immunoprecipitated by rabbit anti-Gigaxonin antibody NBP1-49923, which recognizes an upstream epitope. For blotting immunoprecipitated Gigaxonin, NBP1-49924 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of extract of SW480 and mouse skeletal muscle cells, using GAN antibody. 100 μL Anmelden zum Anzeigen 11 bis 13 Tage
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: Gigaxonin Antibody [NBP2-33569] - Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells. Immunocytochemistry/Immunofluorescence: Gigaxonin Antibody  - Immunofluorescent staining of human cell line RT4 shows localization to microtubules. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
Human Kaninchen Unkonjugiert WB GAN antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 9 bis 11 Tage
Human Kaninchen Unkonjugiert WB Western Blot: Gigaxonin Antibody [NBP1-57821] - THP-1 cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cell lines, using GAN antibody (ABIN5972335) at 1/1000 dilution. 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
Human Kaninchen Unkonjugiert IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded rat brain, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with Gigaxonin Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage

Am meisten referenzierte anti-GAN Antikörper

  1. Human Polyclonal GAN Primary Antibody für IP - ABIN4314110 : Johnson-Kerner, Garcia Diaz, Ekins, Wichterle: Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. in PLoS ONE 2015 (PubMed)

Weitere Antikörper gegen GAN Interaktionspartner

Mouse (Murine) Gigaxonin (GAN) Interaktionspartner

  1. We demonstrate that gigaxonin is crucial for ubiquitin-proteasomal degradation of neuronal Intermediate filaments. Moreover,Intermediate filaments accumulation impairs mitochondrial motility and is associated with metabolic and oxidative stress

  2. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  3. GAN variants are identified in brain sections of mutant mice with giant axonal neuropathy.

  4. results identify gigaxonin as a ubiquitin scaffolding protein that controls MAP1B-LC degradation, and provide insight into the molecular mechanisms underlying human neurodegenerative disorders

  5. Disruption of gigaxonin results in an impaired ubiquitin-proteasome system leading to a substantial accumulation of toxic microtubule-associated protein MAP8 in the null mutants.

  6. At 6 months of age the Gigaxonin-knockout(Deltaexon1;Deltaexon1) mice exhibit a modest hind limb muscle atrophy, a 10% decrease of muscle innervation and a 27% axonal loss in the L5 ventral roots.

Human Gigaxonin (GAN) Interaktionspartner

  1. Our protocol showed high specificity and sensitivity for homozygosity detection and facilitated the identification of novel mutations in GAN, GBA2, and ZFYVE26 in four families affected by hereditary spastic paraplegia or Charcot-Marie-Tooth disease

  2. We believe that molecular and functional investigation of gigaxonin mutations including the exon 8 polymorphism could lead to an improved understanding of the relationship between GAN and cancer

  3. A novel sequence alteration in the gene GAN, c.103G > T, was identified as most likely the underlying cause for a sensory-motor axonal neuropathy in a large consanguineous family presenting as Charcot-Marie-Tooth disease type 2.

  4. a proteomic screen to identify the normal binding partners of GIG, is reported.

  5. The disease is caused by GAN gene mutations on chromosome 16q24.1. To determine clinical and genetic results in Turkish patients with GAN.

  6. This study showed that The instability of Gigaxonin causes Giant Axonal Neuropathy.

  7. A novel missense mutation in four siblings born to consanguineous parents of Arab origin with clinical and molecular features compatible with giant axonal neuropathy.

  8. gigaxonin is a major factor in the degradation of cytoskeletal intermediate filaments

  9. No GAN variant is identified in DNA obtained from well-characterized cases of human neuronal intermediate filament inclusion disease (frontotemporal dementia).

  10. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.

  11. Ubiquitin-proteasome system shown to be responsible for neurodegeneration occurring in GAN-null neurons and plays crucial roles in cytoskeletal functions and dynamics.

  12. 3 new mutants were found in patients with giant axonal neuropathy: an intronic mutation near the splice donor site of intron 2 & a missense mutation in exon 3 (I182N), & 2 identical deletion alleles.

  13. Five families with GAN for mutations in the Gigaxonin gene and mutations were found in four families; three families had homozygous mutations, one had two compound heterozygous mutations and one family had no mutation identified.

  14. gigaxonin mutations impede this ubiquitin degradation process leading to accumulation of microtubule associated proteins and there by impairing cellular functions

  15. a functional important part of the gigaxonin protein is altered by the AluYa5 insertion and causes giant axonal neuropathy [case report]

  16. Study shows that the gigaxonin E3 ligase subunit is normally expressed at a very low level and that various missense and nonsense mutations scattered across the entire GAN gene produce highly unstable protein products.

GAN Antigen-Profil

Protein Überblick

This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).

Genbezeichner und Symbole assoziert mit anti-Gigaxonin (GAN) Antikörper

  • gigaxonin L homeolog (gan.L) Antikörper
  • gigaxonin (gan) Antikörper
  • gigaxonin (GAN) Antikörper
  • giant axonal neuropathy (Gan) Antikörper
  • gigaxonin (Gan) Antikörper
  • A330045G18 Antikörper
  • GAN Antikörper
  • GAN1 Antikörper
  • gigaxonin Antikörper
  • KLHL16 Antikörper
  • MGC81691 Antikörper

Bezeichner auf Proteinebene für anti-Gigaxonin (GAN) Antikörper

gigaxonin , giant axonal neuropathy , giant axonal neuropathy (gigaxonin) , kelch-like family member 16 , kelch-like protein 16

447405 Xenopus laevis
549284 Xenopus (Silurana) tropicalis
713996 Macaca mulatta
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100388790 Callithrix jacchus
100453030 Pongo abelii
100484003 Ailuropoda melanoleuca
100549375 Meleagris gallopavo
100586857 Nomascus leucogenys
430553 Gallus gallus
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100069891 Equus caballus
209239 Mus musculus
307893 Rattus norvegicus
8139 Homo sapiens
100518489 Sus scrofa
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